Plant Biotechnology Persa
عنوان نشریه
pbp
Literature & Humanities
http://pbp.medilam.ac.ir
1
admin
2676-7414
2676-7414
10.61186/pbp
en
jalali
1399
3
1
gregorian
2020
6
1
2
1
online
1
fulltext
fa
The role of bacteria in the treatment of cancer: A comprehensive review
پژوهشي
Research
Cancer is an important public health issue worldwide and is the main cause of death in the developed countries and the second cause of death in the developing countries. There are several treatments for cancer such as photodynamic therapy, surgery, chemotherapy, hormonal therapy, radiotherapy and immunotherapy. Current cancer treatments have various side effects, including the gradual resistance of cancer cells to treatment. The era of targeted cancer therapy has brought about new clinical approaches such as antibodies, small molecules, antiangiogenics, and antivirals. Yet even these strategies remain limited in their ability to accumulate in tumors and tumor penetration, which are the main obstacles in the treatment of cancer. Historic efforts to harness living organisms to fight cancer have recently been revived in the field of synthetic biology. Certain circulating bacteria can intrinsically home in on tumors, and can be engineered to controllably induce local cytotoxicity while remaining unobtrusive to the host system. Due to the ineffectiveness of conventional treatments such as chemotherapy and radiation therapy in advanced tumor stages, resistance to treatment and non-specificity of these treatments, with the advancement of studies in this field, it is hoped that bacterial therapy will add a new dimension to cancer treatment.
Cancer, Bacterial therapy, Toxin, Gene vector, Hypoxia
26
34
http://pbp.medilam.ac.ir/browse.php?a_code=A-10-79-2&slc_lang=fa&sid=1
Erfan
Khadem
Khadem.erf@ymail.com
10031947532846001029
10031947532846001029
Yes
Student Research Committee, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Amir Hossein
Nafari
amirnafari0@gmail.com
10031947532846001030
10031947532846001030
No
Student Research Committee, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Ali
Safarzadeh
Safarzadeh.aa@ymail.com
10031947532846001031
10031947532846001031
No
Student Research Committee, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Reza
Falavand Jozaei
FalavandJozaei@ymail.com
10031947532846001032
10031947532846001032
No
Student Research Committee, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Mohammad
Almasian
almasian26@gmail.com
10031947532846001033
10031947532846001033
No
School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Hossein
Elyasi
hosseineliasy8373@gmail.com
10031947532846001034
10031947532846001034
No
Student Research Committee, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran