fa Phytomedicine كاربردي Review/Systemtic review <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:115%"><span calibri=""><b><span new="" roman="" times="">Objective:</span></b><span new="" roman="" times=""> Endometrial cancer is among the most prevalent malignancies affecting women, and conventional therapies often face limitations such as drug toxicity, cellular resistance, and restricted efficacy. Nanomedicine has emerged as a promising approach capable of significantly enhancing both therapeutic outcomes and diagnostic precision for this disease. This review aims to analyze and synthesize current knowledge on the application of nanoparticles and nanosystems in the treatment and diagnosis of endometrial cancer and endometriosis.</span></span></span><br> <span style="line-height:115%"><span calibri=""><b><span new="" roman="" times="">Methods:</span></b><span new="" roman="" times=""> A comprehensive analytical review was conducted by searching PubMed, Scopus, and Web of Science databases from 2010 to 2025 using relevant keywords. Eligible studies included preclinical investigations involving in vitro and in vivo models, animal studies, and related reviews. Data were extracted qualitatively and thematically to identify the roles of nanoparticles and nanosystems in the therapeutic and diagnostic management of endometrial cancer and endometriosis.</span></span></span><br> <span style="line-height:115%"><span calibri=""><b><span new="" roman="" times="">Results:</span></b><span new="" roman="" times=""> Various nanoparticles and nanosystems including NP@AZL, LDE, SPION@miR-326, CNP, FOL&ndash;PEG&ndash;PLGA + PTX, CXCR4-targeted nanotoxic agents, nMIL-100 (Fe), Porphysomes, and Tamoxifen-loaded solid lipid nanoparticles demonstrated efficacy across cellular, animal, and human models. These systems were shown to inhibit cell proliferation, induce apoptosis, reduce angiogenesis and metastasis, improve lymph node detection, and mitigate the side effects of conventional chemotherapeutics.</span></span></span><br> <span style="line-height:115%"><span calibri=""><b><span new="" roman="" times="">Conclusion:</span></b><span new="" roman="" times=""> The utilization of targeted nanoparticles and nanosystems as delivery vehicles offers considerable potential to enhance therapeutic efficacy and diagnostic accuracy in endometrial cancer while minimizing systemic toxicity.</span></span></span><br> <img alt="" src="./files/site1/images/Copy_editing.png" style="width: 586px; height: 265px;" ><br> &nbsp;</span></span> Nanomedicine, Endometrial cancer, Nanoparticles, Nanosystems, Targeted therapy 0 0 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-25-90&slc_lang=fa&sid=1 Fateme Sadat Najib najibf@sums.ac.ir 10031947532846006359 10031947532846006359 No Department of Obstetrics and Gynecology, Division of Oncology Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Zahra Shirvani Zshirvani@sums.ac.ir 10031947532846006360 10031947532846006360 Yes Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Maryam Aghdaki 3.maryam.aghdaki@yahoo.com 10031947532846006361 10031947532846006361 No Maternal-fetal medicine Research Center, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Elham Izanloo 4.izanlooe9@gmail.com 10031947532846006362 10031947532846006362 No Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran