fa Herbal Drugs پژوهشي Research <span style="font-size:10pt"><span style="line-height:150%"><span optima="" style="font-family:"><span style="color:black"><b>Objective:</b> Food derived antioxidants have a special property for long term use as chemopreventive factor in disease states such as alcoholic liver diseases and hepatitis. This research decided to assess the property of several <i>Eruca sativa</i> <a href="http://www.theplantlist.org/tpl1.1/record/kew-2798746"><span style="color:black"><span style="text-decoration:none"><span style="text-underline:none">Mill</span></span></span></a> extract in ethanol induced liver injury in animals.</span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span optima="" style="font-family:"><span style="color:black"><b>Material and Methods:</b> 30 rats were divided into four groups included treatment groups with E. Sativa extracts (Water and methanolic), prophylactic and control. Oxidants/antioxidants profile, lipid profile, and serum liver functions tests were done.</span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span optima="" style="font-family:"><span style="color:black"><b>Results:</b> The finding revealed that extracts of <i>E. Sativa</i> decrease the alcoholic liver injury. In addition, the extracts of <i>E. sativa</i> may exert their prophylactic and cure role against ethanol oxidative stress by enhancing the antioxidant enzymes and antioxidant molecules levels.</span></span></span></span><br> <b><span style="font-size:11.0pt"><span style="line-height:107%"><span calibri="" style="font-family:">Conclusion:</span></span></span></b><span style="font-size:11.0pt"><span style="line-height:107%"><span calibri="" style="font-family:"> Totally, this research proofed that the E. sativa leaves water extract is better than methanolic extract in decreasing alcoholic liver injury.</span></span></span> Eruca sativa, Antihepatotoxic, Induced Liver, alcoholic liver diseases 1 11 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-56-2&slc_lang=fa&sid=1 Mahmoud E. Ibrahim mibrahim@ymail.com 10031947532846002045 10031947532846002045 No College of Pharmacy, Department of Pharmaceutical Analysis, Ribat National University, Sudan Fatehalrahman F. Magbool fmagbool@yahoo.com 10031947532846002046 10031947532846002046 Yes Assistant Professor of Pharmaceutics, Red Sea University, Sudan Asim Halfawi Shargi halfawishargi@ymail.com 10031947532846002047 10031947532846002047 No Department of Pharmacognosy, Pharmacy Program Nile college Khartoum, Sudan