Plant Biotechnology Persa
عنوان نشریه
pbp
Literature & Humanities
http://pbp.medilam.ac.ir
1
admin
2676-7414
2676-7414
10.61186/pbp
en
jalali
1401
9
1
gregorian
2022
12
1
4
2
online
1
fulltext
fa
Effect of Aju Mbaise on Sperm Morphology, Semen Quality, Sex Hormonal Levels, Gonadosomatic Index and Testicular Histology of Avodart-Induced Rats
Herbal Drugs
پژوهشي
Research
<span style="font-size:10pt"><span style="line-height:150%"><span optima="" style="font-family:"><span style="color:black"><b>Objective:</b> This study evaluated the effect of ethanol extract of Aju Mbaise (EEAM) on sperm morphology, semen quality, sex hormonal levels, gonadosomatic index and testicular histology of Avodart-induced rats.</span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span optima="" style="font-family:"><span style="color:black"><b>Material and Methods:</b> The study had normal control, Avodart control, EEAM control, Avodart+500mg/kg EEAM, and Avodart +1000mg/kg EEAM groups. The rats were orally administered 0.5 mg/kg Avodart and 1 hour later treated with EEAM for 28 consecutive days. The Avodart control had milky white semen with low Ph, volume and semen consistency compared to the normal control and EEAM treated rats with creamy white semen with higher pH and semen consistency, respectively.</span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:150%"><span optima="" style="font-family:"><span style="color:black"><b>Results:</b> The results indicated a substantial decline in spermatozoa mass motility; spermatozoa live proportion, spermatozoa concentrations, normal spermatozoa proportions, animal live weight, paired testes weight and relative testicular weight in the Avodart control compared to the normal control. The Avodart induction caused a significant reduction in the serum testosterone, follicle-stimulating hormone and luteinising hormone levels compared to the normal control. Also, there was a substantial decline in spermatogenic activity and the absence of mature spermatocytes in the lumen of the seminiferous tubules in the Avodart control relative to the normal control and EEAM control. The alterations in the sperm morphology, semen quality, sex hormonal levels and gonadosomatic index were significantly reverted to normal in the EEAM treated Avodart induced rats in a dose-dependent manner compared to the Avodart control.</span></span></span></span><br>
<b><span lang="EN-GB" style="font-size:11.0pt"><span style="line-height:107%"><span calibri="" style="font-family:">Conclusion:</span></span></span></b><span lang="EN-GB" style="font-size:11.0pt"><span style="line-height:107%"><span calibri="" style="font-family:"> These findings showed that EEAM ameliorates Avodart toxicity and improves fertility by restoring sperm quality and sex hormonal levels to normal in rats.</span></span></span>
Aju Mbaise, Male fertility, Sperm quality, Testicular histology, Gonadosomatic index, Sex hormones
22
37
http://pbp.medilam.ac.ir/browse.php?a_code=A-10-411-4&slc_lang=fa&sid=1
Robert Ikechukwu
Uroko
ir.uroko@mouau.edu.ng
10031947532846002050
10031947532846002050
Yes
Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria
Chinomso Friday
Aaron
chinomsoaaron@gmail.com
10031947532846002051
10031947532846002051
No
Department of Biochemistry, Faculty of Biological and Physical Sciences, Abia State University, Uturu, Nigeria
Mercylyn Ezinne
Uche
mercylynuche@gmail.com
10031947532846002052
10031947532846002052
No
Department of Biochemistry, Faculty of Biological and Physical Sciences, Abia State University, Uturu, Nigeria
Chinedu
Aguwamba
lukaspod@yahoo.com
10031947532846002053
10031947532846002053
No
Biochemistry Unit, Department of Chemical Sciences, Faculty of Sciences, Clifford University, Owerrinta, Abia State, Nigeria
Elisha Uko
Ogwo
dr.elishaogwo@yahoo.com
10031947532846002054
10031947532846002054
No
Department of Human Physiology, College of Medicine and Health Sciences, Abia State University, Uturu, Nigeria
Paul Chukwuemaka
Nweje-Anyalowu
aguwambac@clifforduni.edu.ng
10031947532846002055
10031947532846002055
No
Biochemistry Unit, Department of Chemical Sciences, Faculty of Sciences, Clifford University, Owerrinta, Abia State, Nigeria
Solomon Nnah
Ijioma
ijioma.solomon@mouau.edu.ng
10031947532846002056
10031947532846002056
No
Department of Zoology and Environmental Biology, College of Natural and Applied Sciences, Michael Okpara University of Agriculture, Umudike, Nigeria