en Herbal Drugs پژوهشي Research <span style="font-size:12px;"><span style="font-family:Tahoma;"><span style="line-height:150%"><span style="color:black"><b>Objectives:</b> One of the application areas of nanobiotechnology is the use of silver nanoparticles (Nanosilver particles) for a new solution in medical treatments. In the present study, the researchers investigate the effect of nano silver particles of the aqueous extract of <i>Artemisia aucheri</i> on skin wound healing among male rats.</span></span><br> <span style="line-height:150%"><span style="color:black"><b>Material and Methods:</b> After creating wounds in 48 rats, they were randomly divided into 6 groups. Treated with 0.2% AgNPs ointment, 0.2% AgSO4 ointment, &nbsp;&nbsp;0.2% <i>A. aucheri</i> &nbsp;ointment, 3% tetracycline ointment, Eucerin basal ointment, and untreated control group. The tested groups were treated for ten days.</span></span><br> <span style="line-height:150%"><span style="color:black"><b>Results:</b> Treatment with AgNPs ointment significantly increased the amount of vascular contraction, hexose amine and hydroxyproline, and fibrocyte and fibrocyte to fibroblast ratio. Also, in the mentioned group, the wound area and the total number of cells, neutrophils and lymphocytes decreased significantly compared to other groups.&nbsp;</span></span><br> <span style="line-height:150%"><span style="color:black"><b>Conclusion:</b> The nano silver particles of the aqueous extract of <i>A. aucheri</i> accelerate the healing process of skin wounds and reduce the time required for complete wound healing.</span></span><br> &nbsp;</span></span> ,Ocimum basilicum leaf,Zn nanoparticle,FT-IR,Anxiety,Light/dark transition test,Mice 131 136 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-532-2&slc_lang=en&sid=1 Seyed Morteza Hosseini sm_hosseini@yahoo.com 10031947532846005018 0000000199873829 Yes Medicine, Quran and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Namdar yousofvand yousofnam@yahoo.com 10031947532846005019 0000000340172619 No Department of Biology, Faculty of Science, Razi University, 67149-67346, Kermanshah, Iran Samira Zand Samirazand7921@gmail.com 10031947532846005020 10031947532846005020 No Department of Microbiology, Faculty of veterinary Medicine, Urmia University, Urmia, Iran Ali Piranejad-Talatapeh ali.pirnejad@gmail.com 10031947532846005021 10031947532846005021 No Central Laboratory, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran Akram Zangeneh Akramzangeneh2415@gmail.com 10031947532846005022 10031947532846005022 No iotechnology and Medicinal plants Research Center Ilam University of Medical Sciences, Ilam, Iran