fa Herbal Drugs پژوهشي Research <span style="font-size:12px;"><span style="font-family:Tahoma;"><span style="line-height:150%"><span new="" roman="" times=""><span style="color:black"><b>Objectives:</b> One of the application areas of nanobiotechnology is the use of silver nanoparticles (Nanosilver particles) for a new solution in medical treatments. In the present study, the researchers investigate the effect of nano silver particles of the aqueous extract of Artemisia aucheri on skin wound healing among male rats<span dir="RTL" lang="AR-SA"><span style="line-height:150%">.</span></span></span></span></span><br> <span style="line-height:150%"><span new="" roman="" times=""><span style="color:black"><b>Material and Methods:</b> After creating wounds in 48 rats, they were randomly divided into 6 groups<span dir="RTL" lang="AR-SA"><span style="line-height:150%">.</span></span> Treated with 0.2% AgNPs ointment, 0.2% AgSO4 ointment, &nbsp;&nbsp;0.2% A. aucheri ointment, 3% tetracycline ointment, Eucerin basal ointment, and untreated control group. The tested groups were treated for ten days.</span></span></span><br> <span style="line-height:150%"><span new="" roman="" times=""><span style="color:black"><b>Results:</b> Treatment with AgNPs ointment significantly increased the amount of vascular contraction, hexose amine and hydroxyproline, and fibrocyte and fibrocyte to fibroblast ratio. Also, in the mentioned group, the wound area and the total number of cells, neutrophils and lymphocytes decreased significantly compared to other groups.&nbsp;</span></span></span><br> <b><span style="line-height:107%"><span new="" roman="" times="">Conclusion:</span></span></b><span style="line-height:107%"><span new="" roman="" times=""> The nano silver particles of the aqueous extract of A. aucheri</span></span> <span style="line-height:107%"><span new="" roman="" times="">accelerate the healing process of skin wounds and reduce the time required for complete wound healing.</span></span></span></span> AgNPs ointment , Skin wound, Rat 1 7 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-532-6&slc_lang=fa&sid=1 Mohammad Mehdi Zangeneh 10031947532846004953 10031947532846004953 No Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran Akram Zangeneh 10031947532846004954 10031947532846004954 No Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran Navid Etemadi navid@ymail.com 10031947532846004955 10031947532846004955 Yes DVM Graduate, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran Seyyed Jamaleddin Tabatabaei Aghda 10031947532846004956 10031947532846004956 No Department of Microbiology, Faculty of veterinary Medicine, Urmia University, Urmia, Iran Mahtab Pourkamalzadeh 10031947532846004957 10031947532846004957 No Department of Microbiology, Faculty of veterinary Medicine, Urmia University, Urmia, Iran Samira Zand 10031947532846004958 10031947532846004958 No Department of Microbiology, Faculty of veterinary Medicine, Urmia University, Urmia, Iran Mohammad Abbaszadeh 10031947532846004959 10031947532846004959 No Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran Reza Asadzadeh rasadzadeh@ymail.com 10031947532846004960 10031947532846004960 No Assistant Professor of Nephrology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran