fa Herbal Drugs پژوهشي Research <span style="font-size:12px;"><span style="font-family:Tahoma;"><span style="line-height:150%"><span optima=""><span style="color:black"><b><span style="line-height:150%"><span new="" roman="" times="">Background:</span></span></b><span style="line-height:150%"><span new="" roman="" times=""> Many people in the world suffer from gastroduodenal ulcers, therefore, studying the therapeutic strategies of these ulcers are considered as the research priorities in any country. The aim of this study was to survey the preventive property of zinc nanoparticles of <i>Matricaria chamomilla</i> on ethanol-induced gastroduodenal ulcers in rats.</span></span></span></span></span><br> <span style="line-height:150%"><span optima=""><span style="color:black"><b><span style="line-height:150%"><span new="" roman="" times="">Methods:</span></span></b><span style="line-height:150%"><span new="" roman="" times=""> In this study, 30 adult females rats were divided into 5 groups, randomly: negative healthy control receiving distilled water, untreated negative control receiving distilled water, positive control receiving omeprazole 60 mg/kg, one group receiving the aqueous extract of <i>M. chamomilla</i> at 200 mg/kg concentrations, and another group receiving the zinc nanoparticles of aqueous extract <i>M. chamomilla</i> at 0.5mg/kg concentrations. After 14 days, gastroduodenal ulcers were caused by ethanol. Four hours after oral administration of ethanol, the stomach, and duodenum samples of the rats were dissected. Malondialdehyde, Superoxide dismutase activity, and prevention index were measured and histopathological studies were performed.</span></span></span></span></span><br> <span style="line-height:150%"><span optima=""><span style="color:black"><b><span style="line-height:150%"><span new="" roman="" times="">Results:</span></span></b><span style="line-height:150%"><span new="" roman="" times=""> The zinc nanoparticles of aqueous extract <i>M. chamomilla</i> could significantly decrease the raised levels of MDA and INU and enhance SOD and IU as compared to other groups. Also, the zinc nanoparticles of aqueous extract prevented significantly small, medium, and large gastroduodenal ulcers as compared to other groups.</span></span></span></span></span><br> <b><span style="line-height:107%"><span new="" roman="" times="">Conclusion:</span></span></b><span style="line-height:107%"><span new="" roman="" times=""> It seems that the zinc nanoparticles of aqueous extract <i>M. chamomilla</i> can prevent gastroduodenal ulcers in rats without any side effect.</span></span></span></span> Zinc nanoparticle, Matricaria chamomilla, Rat, Gastroduodenal ulcer, Ethanol 45 57 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-532-7&slc_lang=fa&sid=1 Navid Etemadi za@ymail.com 10031947532846004974 10031947532846004974 Yes DVM Graduate, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran