en Phytomedicine كاربردي Review/Systemtic review <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Objective</b>: There has been growing interest in medicinal plants due to their therapeutic properties in safe lower doses, despite their unpleasant smell, bitter taste, and toxicity in higher doses. <i>Ruta graveolens</i> L., commonly known as the herb of grace, common rue, rue, ruda, sodab, fijen, and al-suzab is a potential therapeutic candidate with variable healing properties and traditional uses. One of its lesser-known uses is in the treatment of eye conditions. The current study aimed to investigate the ophthalmological potential of <i>Ruta graveolens</i> L. using available scientific literature.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Methods</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: </span></span></b>To this end, we extensively searched Scopus, Science Direct, Web of Science, Embase, PubMed, Google Scholar, IranMedex, SID, and Magiran for related literature on the cultural, historical and scientific aspects of <i>Ruta graveolens</i> L. and ophthalmology. Also, traditional Persian medicine books including Al-Qanun Fi Al-Tibb, Al-Hawi Fi Al-Tibb, Al-Abniya, and Ikhtiyarat Badiei thoroughly searched to find the potential application of rue in ophthalmology.<span lang="FA" dir="RTL" style="font-family:"Times New Roman",serif"></span></span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Results</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: &nbsp;</span></span></b>Our historical, literary, and traditional medicine data revealed that <i>R. graveolens</i> L. used in the ophthalmic field probably due to its beneficial effects in the past. Also, there are some modern studies elucidated the beneficial effects of this plant in ophthalmology.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Conclusion</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: &nbsp;</span></span></b>This study suggests that <i>R. graveolens</i> L. plant can be a promising ophthalmic drug due to its specific ocular benefits warranting further research with modern technologies.</span></span><br> &nbsp; Integrative Medicine,Medicinal plant,Pharmacology,Persian Medicine,Ophthalmology,Ruta graveolens L. 64 53 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-647-1&slc_lang=en&sid=1 Mohammad Amrollahi-Sharifabadi amrollahi.m@lu.ac.ir 10031947532846005006 10031947532846005006 Yes Department of Basic Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran. 5th Kilometer of Khorramabad-Boroujerd Highway Khoramabad, Lorestan, 68151-44316 Iran. E-mail: amrollahi.m@lu.ac.ir, ORCID: 0000-0002-4458-7689 Mohammad Kamalpour kamalpour.m@lu.ac.ir 10031947532846005007 10031947532846005007 No Department of Basic Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, IranORCID: 0000-0001-6431-7056 Jamal Rezaei Orimi Rezaei.history93@gmail.com 10031947532846005008 10031947532846005008 No 3Pre-hospital Emergency Medical Services and Disaster Management Center, Mazandaran University of Medical Sciences, Sari, Iran. E-mail: Rezaei.history93@gmail.com, ORCID: 0000-0002-2356-5552& Department of Persian Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Zahra Aghabeiglooei Aghabeiglooei@gmail.com 10031947532846005009 10031947532846005009 No Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran. ORCID: 0000-0001-8467-4202 Ebrahim S alimi-Sabour E.salimisabour@gmail.com 10031947532846005010 10031947532846005010 No Department of Pharmacognosy and Traditional Pharmacy, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran. ORCID: 0000-0002-5315-2126 Sahar Abdelaziz Sah_abdelaziz@zu.edu.eg 10031947532846005011 10031947532846005011 No 7Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, 44519 Zagazig, Egypt. ORCID: 0000-0001-9475-6121