en Bioactive Compounds پژوهشي Research <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><b>Objective:</b> Plants have been a good source of lead compounds for nutraceutical and therapeutic potentials against ailments of human and animal importance since the introduction of man on earth. The lead compounds continue to be precursors in developing drugs with insignificant side effects and replace synthetic medicines. Several phytochemical compounds have been reported in different species of Aloe belonging to the family Asphodelaceae. The established phytoconstituents from the genus Aloe possess several activities, including antiviral, antibacterial, anticancer, neuroprotective, and antioxidant properties. However, there is limited information related to phytochemicals from <i>Aloe</i> <i>rabaiensis</i> Rendle.<br> <b>Methods:</b> This is the first study investigating the phytoconstituents in <i>A. rabaiensis</i> from Tanzania. Gas chromatography-mass spectrometry (GC-MS) analysis of <i>A. rabaiensis</i> leaf extracts was performed using GC-MS equipment (Agilent Technologies) to identify the phytochemical constituents.<br> <b>Results:</b> The GC-MS analysis demonstrated the presence of fourteen and six compounds from the leaf&rsquo;s ethyl acetate and chloroform extracts of <i>A. rabaiensis</i>, respectively. The compounds belong to different classes, including amines, esters, carboxylic acid, ketone, phenol, alkane and alcohol. No common compound(s) was/were identified from both extracts.<br> <b>Conclusion:</b> The identified phytoconstituents, backed with reported ethnomedical and ethnoveterinary use of <i>A. rabaiensis</i>, are evidence, thus, significant precursors for drug development.</span></span></div> A. rabaiensis,GC-MS,Phytoconstituents,Pharmacological properties,Plant extract 68 77 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-648-1&slc_lang=en&sid=1 Mwanaisha Mkangara mkangaram@yahoo.com 10031947532846005610 10031947532846005610 Yes Faculty of Science, Technology and Environmental Studies, The Open University of Tanzania, Dar es Salaam, Tanzania