fa Clinical پژوهشي Research <p data-end="697" data-start="110"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><strong data-end="124" data-start="110">Objective:</strong>&nbsp;Neonatal colic is among the most common gastrointestinal disorders in newborns, often causing persistent crying, restlessness, and significant distress for both infants and parents. This condition typically occurs between 1 and 4 months of age and may be managed through home remedies, medical interventions, maternal dietary modifications, or pharmacological treatments. In Iranian traditional medicine, medicinal plants play a key role in alleviating colic. This study aims to identify and report the main medicinal plants used for the treatment of colic in infants.</span></span></p> <p data-end="1044" data-start="699"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><strong data-end="715" data-start="699">Methodology:</strong>&nbsp;This review was conducted through a comprehensive search using keywords including &ldquo;colic,&rdquo; &ldquo;children,&rdquo; &ldquo;traditional medicine,&rdquo; &ldquo;medicinal plants,&rdquo; and &ldquo;treatment&rdquo; in databases such as Google Scholar, SID, Magiran, and Scopus. Irrelevant studies were excluded, and eligible articles were systematically reviewed and analyzed.</span></span></p> <p data-end="1412" data-start="1046"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><strong data-end="1058" data-start="1046">Results:</strong>&nbsp;Findings revealed that medicinal plants such as <em data-end="1129" data-start="1109">Anethum graveolens</em>, <em data-end="1147" data-start="1131">Acorus calamus</em>, <em data-end="1169" data-start="1149">Foeniculum vulgare</em>, <em data-end="1190" data-start="1171">Pimpinella anisum</em>, <em data-end="1215" data-start="1192">Matricaria chamomilla</em>, <em data-end="1233" data-is-only-node="" data-start="1217">Mentha spicata</em>, <em data-end="1256" data-start="1235">Zingiber officinale</em>, and <em data-end="1275" data-start="1262">Carum carvi</em> are among the most frequently recommended and practically applied herbal remedies for infantile colic in traditional medicine sources.</span></span></p> <p data-end="1825" data-start="1414"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><strong data-end="1429" data-start="1414">Conclusion:</strong>&nbsp;Anti-colic medicinal plants appear to alleviate symptoms of infantile colic through analgesic, antispasmodic, and sedative mechanisms. These findings highlight the therapeutic potential of medicinal plants as a complementary approach for colic management. However, clinical validation and careful monitoring by healthcare professionals are necessary to ensure efficacy and safety in infants.</span></span></p> Digestive system, Children, Colic, Pain, Medicinal plants, Traditional medicine 89 94 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-91-7&slc_lang=fa&sid=1 Ali Zolfigol dr.alizolfi@gmail.com 10031947532846005549 10031947532846005549 No Assistant Professor of Pediatric Cardiology, Department of Pediatric Disease, School of Medicine, Shahid Motahari Hospital, Urmia University of Medical Sciences, Urmia, Iran Mohadeseh Pirhadi m.pirhadi371@gmail.com 10031947532846005550 10031947532846005550 Yes Department of Environmental Health ‌Engineering, Food Safety Division, School of Public Health, Tehran University of Medical Sciences and Health Services, Tehran, Iran