fa Clinical پژوهشي Research <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;">Cichorium intybus, commonly known as chicory, is a medicinal herb with a long history of use in traditional Iranian medicine. Among its numerous therapeutic properties, chicory is particularly noted for its hepatoprotective effects, which may offer valuable support in the management of neonatal jaundice. Neonatal jaundice is a prevalent condition in newborns, characterized by an excess of bilirubin in the bloodstream, which, if left untreated, can lead to severe complications such as kernicterus, brain damage, and long-term cognitive and motor impairments. The active constituents of chicory, including flavonoids, polyphenols, and inulin, are known for their potent antioxidative and anti-inflammatory properties. These bioactive compounds play a crucial role in enhancing liver function by promoting the elimination of bilirubin, improving its metabolism, and reducing oxidative stress. Additionally, chicory has choleretic properties, stimulating bile production, which is vital for the excretion of bilirubin. Although preclinical studies have shown promising results, it is essential to conduct more rigorous clinical trials to establish the most effective dosage, safety profile, and therapeutic potential of chicory for neonatal jaundice. Further research will be pivotal in determining its role as a complementary treatment option in managing this common yet serious neonatal condition.<span lang="FA" dir="RTL" style="font-family:&quot;Times New Roman&quot;,serif"></span></span></span><br> <br> &nbsp;</div> Infants, Jaundice, Bilirubin, Herbal therapy, Traditional medicine, Remedy 119 121 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-35-6&slc_lang=fa&sid=1 Ali Zolfigol dr.alizolfi@gmail.com 10031947532846005672 10031947532846005672 No Assistant Professor of Pediatric Cardiology, Department of Pediatric Disease, School of Medicine, Shahid Motahari Hospital, Urmia University of Medical Sciences, Urmia, Iran Zohre Eftekhari z_eftekhari@pasteur.ac.ir 10031947532846005673 10031947532846005673 Yes Biotechnology Department , Pasteur Institute of Iran, Tehran , Iran