fa <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:150%"><span calibri=""><b><span style="line-height:150%"><span new="" roman="" times="">Objective:</span></span></b><span style="line-height:150%"><span new="" roman="" times=""> Type 2 diabetes is linked to a heightened risk of coronary heart disease (CHD) due to metabolic and oxidative disturbances. Glutathione, a vital antioxidant, and malondialdehyde (MDA), a marker of oxidative stress, are critical in assessing oxidative damage and cellular stress. This study aims to examine the serum levels of these markers in patients with type 2 diabetes and CHD to gain insight into the relationship between oxidative stress and cardiovascular disease in this population.</span></span></span></span><br> <span style="line-height:150%"><span calibri=""><b><span style="line-height:150%"><span new="" roman="" times="">Methods:</span></span></b><span style="line-height:150%"><span new="" roman="" times=""> This cross-sectional study was conducted at Khorramabad Heart Hospital in Western Iran, involving 100 patients with type 2 diabetes with CHD (T2DM-CHD) over a two-month period. Blood samples were also collected from fasting volunteers in a control group for comparative purposes. After centrifugation and serum separation, biochemical assays were performed to measure serum levels of MDA and glutathione.</span></span></span></span><br> <span style="line-height:150%"><span calibri=""><b><span style="line-height:150%"><span new="" roman="" times="">Results:</span></span></b><span style="line-height:150%"><span new="" roman="" times=""> The serum level of MDA in the T2DM-CHD group was 19.3 &plusmn; 16.8 &micro;mol/mg protein, significantly higher than the control group&rsquo;s level of 6.9 &plusmn; 3.3 &micro;mol/mg protein. Conversely, serum glutathione levels in the diabetic group were 15.3 &plusmn; 6.5 &micro;mol/mg protein, markedly lower compared to the control group&rsquo;s 34.8 &plusmn; 10 &micro;mol/mg protein.</span></span></span></span><br> <span style="line-height:150%"><span calibri=""><b><span style="line-height:150%"><span new="" roman="" times="">Conclusion:</span></span></b><span style="line-height:150%"><span new="" roman="" times=""> The findings suggest that patients with T2DM-CHD exhibit elevated levels of MDA and reduced levels of glutathione, indicating significant oxidative stress. This imbalance may contribute to the progression of diabetes-related complications and cardiovascular diseases. Therefore, incorporating antioxidants as medications or supplements may be an effective strategy to mitigate oxidative stress and enhance clinical outcomes in these patients. Further research is required to identify the optimal types and dosages of antioxidants.</span></span></span></span></span></span> Cardiovascular disease, Type 2 diabetes, Coronary artery disease, Diabetes, Iran 80 83 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-423-8&slc_lang=fa&sid=1 Babak Baharvand Ahmadi bbaharvandahmadi@ymail.com 10031947532846003544 10031947532846003544 Yes Department of Cardiology, School of Medicine Social Determinants of Health Research Center Shahid Madani Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran Reyhaneh Narenjkar Esfahani reyhanehnarenjkar@gmail.com 10031947532846003545 10031947532846003545 No Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran