fa Bioactive Compounds پژوهشي Research <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><b>Objective:</b> Insomnia or sleep disorders refer to conditions characterized by insufficient sleep, difficulty falling asleep, or sudden awakenings during the night. These issues can be distressing for some individuals and significantly affect their daily functioning. While various factors contribute to insomnia, scientific research continues to explore the body&rsquo;s need for sleep and its underlying causes. The aim of this study is to investigate the effects of medicinal plants on sleep improvement and the treatment of insomnia. In this research, the mechanisms influencing insomnia and how Iranian medicinal plants impact sleep quality are analyzed and reported.<br> <b>Methodology:</b> For this review, key terms such as medicinal plants, traditional medicine, native Iranian plants, insomnia, and sleep treatment were used. Relevant articles were searched from reputable scientific databases including PubMed, Google Scholar, Scopus, and Web of Science. Additionally, specialized resources such as reference books, encyclopedias, and online sources were consulted for data collection. All available articles and resources were carefully examined and analyzed to identify medicinal plants used in traditional Iranian medicine to improve sleep.<br> <b>Results:</b> Traditional Iranian medicine offers a range of herbal remedies for sleep improvement and insomnia. Notable plants include saffron, thyme, lavender, pear, sage, rosemary, eucalyptus leaves, mint, ginger, lemon balm, cinnamon, chamomile, passionflower, jujube, hops, violet flower, borage, bitter orange, milk thistle, wild lettuce, green tea, and bitter orange, all of which are part of Iran&rsquo;s native flora used in traditional treatments.<br> <b>Conclusion:</b> The findings of this review demonstrate that medicinal plants are recognized as natural and safe treatments for insomnia and sleep enhancement. These plants primarily exert their effects by regulating the central nervous system, reducing anxiety and stress, and enhancing melatonin production.</span></span><br> &nbsp;</div> Herbal remedies, insomnia, traditional medicine, sleep treatment, anxiety, melatonin, central nervous system 70 75 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-423-11&slc_lang=fa&sid=1 Fatemeh Hamzeh fhamzeh@ymail.com 10031947532846005651 10031947532846005651 No Department of Neurology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Damoun Razmjoue d.razmjoue@gmail.com 10031947532846005652 10031947532846005652 Yes Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran