fa Phytochemistry كاربردي Review/Systemtic review <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><b>Objective: </b>Gestational diabetes arises due to the body&#39;s inability to effectively regulate blood glucose levels, caused by hormonal changes and insulin resistance, and if left untreated, it jeopardizes the health of both the mother and the fetus. This condition is classified into two types: A1 (manageable through diet) and A2 (requiring medication or insulin). Genetic factors and excess weight can also contribute to its onset. The aim of this study is to provide a comprehensive review of the most significant medicinal plants native to Iran that are effective in managing gestational diabetes and to explore their pharmacological mechanisms.<br> <b>Methodology: </b>For this review, a search was conducted in reliable databases such as PubMed, Scopus, SID, and Google Scholar, as well as traditional Iranian medicine reference books, to gather articles related to medicinal plants effective against gestational diabetes. The medicinal plants related to gestational diabetes in traditional Iranian medicine were selected for this review. The objective of this study was to identify plants that can be used for managing gestational diabetes with minimal side effects.<br> <b>Results: </b>In traditional Iranian medicine, several medicinal plants have been recommended for the management of gestational diabetes, including <i>Trachyspermum ammi</i> (L.) Sprague, <i>Foeniculum vulgare</i> Mill., <i>Origanum vulgare</i> L., <i>Myrtus communis</i> L., <i>Eucalyptus globulus</i> Labill., <i>Zingiber officinale</i> Roscoe, <i>Salvia officinalis</i> L., <i>Cinnamomum verum</i> J. Presl, <i>Aloysia citrodora</i> Pal&aacute;u, <i>Lippia citriodora</i> Kunth, <i>Cucurbita pepo</i> L., <i>Artemisia absinthium</i> L., <i>Artemisia herba-alba</i> Asso, <i>Juglans regia</i> L., <i>Cuminum cyminum</i> L., <i>Vicia faba</i> L., <i>Olea europaea</i> L., <i>Thymus vulgaris</i> L., <i>Mentha piperita</i> L., <i>Cuminum cyminum</i> L., <i>Rosmarinus officinalis</i> L., <i>Solanum melongena</i> L.. These plants have been used for controlling gestational diabetes in traditional Iranian medicine.<br> <b>Conclusion: </b>Gestational diabetes, as a common condition during pregnancy, requires careful and effective management to prevent serious complications for both the mother and the fetus. In traditional Iranian medicine, many medicinal plants are recognized as adjunctive treatments for managing gestational diabetes. The use of these plants could serve as a natural and cost-effective strategy alongside standard medical treatments, particularly in cases of gestational diabetes. However, it is crucial that the consumption of these plants be supervised by a healthcare professional to avoid any potential side effects or drug interactions.</span></span><br> &nbsp;</div> 57 64 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-25-68&slc_lang=fa&sid=1 Shabnam Vazifekhah shabnam.vazifekhah@yahoo.com 10031947532846005907 10031947532846005907 Yes Department of Obstetrics and Gynecology, School of Medicine, Kowsar Woman's General University Hospital, Urmia University of Medical Sciences, Urmia, Iran Alireza Soleimani Mamalo 10031947532846005908 10031947532846005908 No Patient Safety Research Center, Clinical Research Institute, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran