fa Herbal Drugs پژوهشي Research <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><b>Objective:</b> Headache is one of the most common somatic complaints, often triggered by factors such as stress, fatigue, dehydration, or neurological disturbances. Its manifestations vary in type and intensity and frequently impair quality of life. Treatment depends largely on identifying the underlying cause and may involve lifestyle modifications in combination with pharmacological interventions. However, recurrent use of synthetic analgesics can lead to complications such as gastrointestinal irritation, hepatic damage, and drug dependence. Caution is therefore warranted, and medical supervision is recommended when using such medications. In this context, the present review highlights the principal medicinal plants employed in Iranian traditional medicine for headache management.<br> <b>Methodology:</b> A comprehensive literature search was performed using the keywords &ldquo;medicinal plants,&rdquo; &ldquo;headache,&rdquo; &ldquo;traditional medicine,&rdquo; and &ldquo;Iran&rdquo; across major scientific databases, including PubMed, Scopus, Google Scholar, and Web of Science.<br> <b>Results:</b> The review identified a wide range of herbs traditionally used in Iranian medicine for headache relief. These include peppermint, valerian, lavender, coriander, German chamomile, sage, licorice, vervain, black tea, ginger, violet, green tea, Syrian rue, basil, thyme, cinnamon, rosemary, lemon balm, St. John&rsquo;s wort, black pepper, willow, passionflower, orange blossom, borage, oregano, saffron, fennel, Damask rose, marshmallow, hyssop, and walnut.<br> <b>Conclusion:</b> Iranian traditional medicine provides a rich pharmacopeia of medicinal plants that represent effective and generally well-tolerated alternatives to synthetic treatments for headache. These remedies offer a natural therapeutic option with fewer side effects. Nevertheless, further clinical research is required to validate their efficacy and facilitate their integration into evidence-based medical practice.<br> <br> <img alt="" src="./files/site1/images/Copy_editing.png" style="width: 586px; height: 265px;" ></span></span></div> Brain, Head, Headache, Treatment, Medicinal plants, Traditional medicine, Iran 0 0 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-1324-1&slc_lang=fa&sid=1 Ali Akbar Nasiri nasiriali7@gmail.com 10031947532846005830 10031947532846005830 Yes Department of Anesthesiology, School of Medicine, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran