en Ethno-pharmacology كاربردي Review/Systemtic review <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:115%"><b>Objective:</b> Anxiety is a prevalent psychological disorder that substantially impairs quality of life. Traditional Iranian Medicine (TIM) has long utilized medicinal plants as natural, low-side-effect interventions for anxiety management. This study aims to identify TIM-documented plants with anxiolytic properties and to explore their underlying mechanisms of action.</span><br> <span style="line-height:115%"><b>Methods:</b> A systematic search was conducted across reputable TIM texts, herbal pharmacopoeias, and online scientific databases. Medicinal plants reported to have anxiolytic effects were identified, and their mechanisms of action were analyzed.</span><br> <span style="line-height:115%"><b>Results:</b> Identified plants include <i>Melissa officinalis</i> L., <i>Valeriana officinalis</i> L., <i>Borago officinalis</i> L., <i>Lavandula angustifolia</i> Mill., <i>Crocus sativus</i> L., <i>Matricaria chamomilla</i> L., <i>Zingiber officinale</i> Roscoe, <i>Cinnamomum verum</i> J. Presl, <i>Foeniculum vulgare</i> Mill., <i>Glycyrrhiza glabra</i> L., <i>Passiflora incarnata</i> L., <i>Origanum majorana</i> L., <i>Camellia sinensis</i> (L.) Kuntze, <i>Rosmarinus officinalis</i> L., <i>Hypericum perforatum</i> L., <i>Elaeagnus angustifolia</i> L., <i>Rosa damascena</i> Mill., <i>Berberis vulgaris</i> L., <i>Silybum marianum</i> (L.) Gaertn., <i>Anethum graveolens</i> L., <i>Alcea rosea</i> L., <i>Valeriana montana</i> Scop., <i>Salix alba</i> L., <i>Rosa</i> spp., <i>Boswellia serrata</i> Roxb., and <i>Cichorium intybus</i> L. These plants exert anxiolytic effects via neurotransmitter modulation, hormonal regulation, antioxidant activity, and sleep enhancement.</span><br> <span style="line-height:115%"><b>Conclusion:</b> TIM-based medicinal plants represent promising, safe, and complementary strategies for anxiety management. Nonetheless, establishing standardized dosages, ensuring formulation quality, and conducting rigorous clinical trials are crucial to validate efficacy and achieve reproducible therapeutic outcomes<br> <span calibri=""><span new="" roman="" times=""><img alt="" src="./files/site1/images/copuediting.png" style="width: 586px; height: 265px;" ></span></span></span><br> &nbsp;</span></span></div> ,Anxiety,Medicinal Plants,Traditional Iranian Medicine,Sedative,Natural Therapy 143 153 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-1529-2&slc_lang=en&sid=1 Hamid Ahmadi hahmadi@ymail.com 10031947532846006282 10031947532846006282 No Department of Psychiatry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran Azita Keshavarz akeshavarz@ymail.com 10031947532846006283 10031947532846006283 No Department of Psychology, Torbat-e Jam Branch, Islamic Azad University, Torbat-e Jam, Iran Mojtaba Khaksarian mojkhaksar@yahoo.com 10031947532846006284 10031947532846006284 Yes Department of Physiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran