en Bioactive Compounds كاربردي Review/Systemtic review <br> <span style="font-family:Times New Roman;"><span style="font-size:14px;"><span style="line-height:150%"><span new="" roman="" times=""><strong>Objective:</strong> Renal ischemia-reperfusion injury (RIRI) is a major cause of acute kidney damage following surgery, trauma, organ transplantation, and thrombotic events, primarily due to oxidative stress and cellular injury. Nanoparticles (NPs) have emerged as promising therapeutic tools by enabling targeted drug delivery, controlled release, and reduced systemic toxicity. This systematic review evaluates the effects of NP-based therapies on IRIR, with a focus on their modulation of key molecular signaling pathways.</span></span><br> <span style="line-height:150%"><span new="" roman="" times=""><strong>Methods:</strong> A systematic search was performed in PubMed, Scopus, and Web of Science for studies published between 1990 and 2024. After applying predefined inclusion and exclusion criteria, 14 studies were included in the final analysis.</span></span><br> <span style="line-height:150%"><span new="" roman="" times=""><strong>Results:</strong> NP-based interventions consistently improved experimental RIRI outcomes by reducing oxidative stress, preserving renal function markers, attenuating inflammation and fibrosis, and modulating immune and gene-expression responses. These effects were observed across different nanoformulations and therapeutic cargos.</span></span><br> <span style="line-height:150%"><span new="" roman="" times=""><strong>Conclusion:</strong> Current evidence supports nanoparticles as promising candidates for the prevention and treatment of renal IRIR, with clear potential for translation into advanced renal drug-delivery and renoprotective strategies<span lang="EN"><span style="line-height:150%">.<br> <img alt="" src="./files/site1/images/copuediting.png" style="width: 586px; height: 265px;" ></span></span></span></span><br> &nbsp;</span></span> Nanoparticle exposure,Renal ischemia-reperfusion injury,Signaling pathways 0 0 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-1548-1&slc_lang=en&sid=1 maryam kheiry kheiry-m@medilam.ac.ir 10031947532846006335 10031947532846006335 No Non-Communicable Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran Mohammad Reza Kaffashian kaffashian-mr@medilam.ac.ir 10031947532846006336 10031947532846006336 No Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Alireza Aliboroni ar81ab@gmail.com 10031947532846006337 10031947532846006337 No Non-Communicable Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran maryam maleki maryammaleki777@yahoo.com 10031947532846006338 10031947532846006338 Yes Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran