fa Herbal Drugs كاربردي Review/Systemtic review <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:115%"><span calibri=""><b><span new="" roman="" times="">Objective:</span></b><span new="" roman="" times=""> Burns are among the most common forms of skin injury and are frequently associated with high rates of complications, infections, and delayed wound healing. Key factors that impede recovery include disruption of the skin barrier, microbial imbalance (dysbiosis), persistent inflammation, and elevated oxidative stress. In recent years, probiotic therapy has emerged as a novel and complementary strategy to enhance wound repair, primarily through modulation of immune responses and the microbiota of both the skin and gut.</span></span></span><br> <span style="line-height:115%"><span calibri=""><b><span new="" roman="" times="">Methods:</span></b><span new="" roman="" times=""> This concise review systematically examined peer-reviewed literature indexed in reputable databases, including PubMed, Scopus, and Web of Science. Preclinical studies, encompassing cellular and animal models, as well as clinical trials investigating the effects of probiotics on burn wound healing, were analyzed. The review focused on publications from 2010 to 2025, with emphasis on probiotic strains, routes of administration, and wound healing outcomes.</span></span></span><br> <span style="line-height:115%"><span calibri=""><b><span new="" roman="" times="">Results:</span></b><span new="" roman="" times=""> Probiotics, particularly <i>Lactobacillus plantarum</i>, have demonstrated notable efficacy in burn wound repair by inhibiting pathogenic microorganisms, reducing inflammation, and accelerating epithelialization, even under infected or diabetic conditions. Other <i>Lactobacillus</i> strains, including <i>L. acidophilus</i>, <i>L. rhamnosus</i>, and <i>L. casei</i>, facilitate faster wound recovery by enhancing fibroblast activity and shortening the inflammatory phase. In contrast, <i>Bifidobacterium</i> species primarily support burn patients by strengthening mucosal immunity and mitigating systemic infections. Overall, both topical and oral probiotic interventions appear to be safe and effective adjunctive strategies, exerting their effects through modulation of the microbiome and control of inflammation.</span></span></span><br> <span style="line-height:115%"><span calibri=""><b><span new="" roman="" times="">Conclusion:</span></b><span new="" roman="" times=""> Current preclinical and clinical evidence suggests that probiotic therapy can serve as a safe and effective approach to accelerate burn wound healing via modulation of the microbiome and inflammatory responses. Nonetheless, well-designed randomized clinical trials are required to determine the optimal strains, dosages, and routes of administration for maximum therapeutic benefit.<br> <img alt="" src="./files/site1/images/copuediting.png" style="width: 586px; height: 265px;" ></span></span></span><br> &nbsp;</span></span> Probiotic therapy, Burn wounds, Wound healing, Microbiota, Inflammation, Treatment 211 221 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-25-87&slc_lang=fa&sid=1 Afshin Zahed dr.afshinz@gmail.com 10031947532846006296 0009-0005-1803-721x No Department of Surgery, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Zahra Teymouri Azargholenji zahra.teymouri@stud.semmelweis.hu 10031947532846006297 0009-0003-3580-1289 No 5th-Year Medicine Student, Semmelweis University, Budapest, Hungary Mohammad Ali Abbasian mohammadali.abbasian@stud.semmelweis.hu 10031947532846006298 10031947532846006298 Yes 5th-Year Medicine Student, Semmelweis University, Budapest, Hungary