Plant Biotechnology Persa

en Probiotic Therapy in Wound Healing: A Review of Key Evidence on Probiotic-Based Wound Repair Phytomedicine كاربردي Review/Systemtic review Objective: Wound healing is a complex, dynamic, and multi-phase biological process comprising hemostasis, inflammation, proliferation, and tissue remodeling. This process is influenced by multiple factors, including immune status, nutritional condition, and host microbiome balance. In recent years, increasing attention has been directed toward the role of the microbiome particularly probiotics in enhancing wound repair. These beneficial microorganisms may accelerate healing by modulating inflammatory responses and promoting tissue regeneration. This review aims to critically examine the most relevant scientific evidence regarding the role of probiotics in wound healing and to identify effective strains involved in reducing inflammation, enhancing collagen synthesis, and accelerating tissue regeneration. Methods: In this narrative review, relevant studies were retrieved from major scientific databases using the keywords “probiotics,” “wound healing,” and “tissue regeneration.” The collected literature was analyzed and categorized based on probiotic strains, mechanisms of action, and reported clinical outcomes. A descriptive and analytical synthesis was then performed. Results: Available evidence indicates that several Lactobacillus species particularly Lactobacillus rhamnosus, L. reuteri, L. plantarum, and L. casei demonstrate significant potential in accelerating wound healing through anti-inflammatory effects and enhanced collagen synthesis. In addition, Bifidobacterium lactis and B. breve have shown beneficial roles in epithelialization and tissue regeneration. Among yeasts, Saccharomyces cerevisiae and S. boulardii are associated with reduced inflammation and improved structural integrity of repaired tissue. Furthermore, multi-strain probiotic formulations appear to be more effective than single-strain preparations in controlling infection and improving clinical outcomes. Overall, the primary mechanisms involve modulation of the microbiome, inhibition of pathogenic microorganisms, and activation of tissue repair signaling pathways. Conclusion: Probiotics represent a promising therapeutic strategy in wound management. Current evidence suggests that these microorganisms can support wound healing through restoration of microbial balance, reduction of inflammation, and stimulation of tissue regeneration. Nevertheless, further large-scale clinical trials are required to determine optimal dosing, strain specificity, and long-term safety profiles. <img alt="" src="./files/site1/images/copuediting.png" style="width: 586px; height: 265px;" >   Probiotics,wound healing,Lactobacillus,Bifidobacterium,microbiome 233 248 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-1557-1&slc_lang=en&sid=1 Arash Zaminy zaminy_a@gums.ac.ir 10031947532846006353 10031947532846006353 No Burn and Regenerative Medicine Research Center, Guilan University of Medical Sciences, Rasht, Iran Mehrnaz Balani mehrnazbalani@gmail.com 10031947532846006354 10031947532846006354 No Department of Anatomical Sciences, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Saber Abbaszadeh saberabaszade1370@gmail.com 10031947532846006355 10031947532846006355 No Medical Student, Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Bahar Eslami eslami_bahar@yahoo.com 10031947532846006356 10031947532846006356 No Medical Student, Student Research Committee, School of Medicine, Guilan University of MedicalSciences, Rasht, Iran Mahoor Khosravani Hasan Kiadeh Mahoorkhosravani0@gamil.com 10031947532846006357 10031947532846006357 No Cellular Molecular Genetics Group, Rasht Islamic Azad University, Rasht, Iran Navid Pourzardosht Pourzardosht@gums.ac.ir 10031947532846006358 10031947532846006358 Yes School of Medicine, Cellular and Molecular Research Center, Guilan University of Medical Sciences, Rasht, Iran