fa Herbal Drugs پژوهشي Research <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;">Plague, caused by Yersinia pestis, remains one of the most devastating infectious diseases in human history. While modern antibiotics have significantly reduced mortality rates, historical medical systems, including traditional Persian medicine, have documented various preventive and supportive approaches involving medicinal and aromatic plants. This review examines the role of these plants in managing plague, as described in Persian medical sources, and highlights their potential relevance in modern pharmacological research. Classical Persian physicians recommended plants such as Peganum harmala, Ferula gummosa, Myrtus communis, Zataria multiflora, Allium sativum and Boswellia sacra for air purification, reducing inflammation and strengthening the body&#39;s defences. Contemporary studies suggest that many of these plants contain bioactive compounds with antimicrobial, antioxidant and anti-inflammatory properties. However, direct evidence of their efficacy against <i>Y. pestis</i> remains limited. Further research is needed to investigate their mechanisms, safety, and potential contribution to future antimicrobial strategies.<span lang="FA" dir="RTL" style="font-family:"Times New Roman",serif"></span></span></span></div> <span style="font-size:14px;"><span style="font-family:Times New Roman;">&nbsp;</span></span> Medicinal herbs, Plague, Remedy 144 141 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-25-92&slc_lang=fa&sid=1 Masoumeh Tahmasbi 0000-0002-3035-1042 No Department of Emergency Medicine, School of Medicine, Imam Khomeini Hospital, Ilam University of Medical Sciences, Ilam, Iran Mahmoud Bahmani mahmood.bahmani@gmail.com 0000-0002-9643-9274 Yes Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran