en Herbal Drugs پژوهشي Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="line-height:150%"><span style="font-family:Optima"><span style="color:black">Ethnomedicinal plants are considered as the recent resources for producing components to healt wounds. <i>Stevia rebaudiana</i> is a native plant in Iran, which has been used as an anti-inammatory, antioxidant, antibacterial, antifungal, antiparasitic, antiviral, and antidiabetic agent. In this study, the authors describe the property of aqueous extract of <i>S. rebaudiana</i> on wound healing markers in Sprague-Dawley male rats. Full-thickness excisional wounds (2&times;2 cm) was induced on the back of 32 rats. In this study, rats were randomly divided into four main groups (n=8), untreated (control) and treated with 1ml basal cream, 1ml tetracycline (3%), and 1ml<i> S. rebaudiana</i> aqueous extract 10% for 10 days. Animals of each group were euthanized at 10 days post-injury (DPI) and wounds were assessed through gross and histopathological analyses. Treated animals with <i>S. rebaudiana</i> demonstrated a considerable decrease in the wound area during the experiment compared to control, basal cream, and tetracycline groups. Parameters such as healing tissue alignment and epithelialization indicated substantial changes when compared to other groups. Moreover, treatment with<i> S. rebaudiana</i> decreased the number of wound surface area, lymphocytes, and macrophages, it increased the number of blood vessels and fibrocytes compared to other groups at 10 days. Thus, the present research shows the wound healing effect of the<i> S. rebaudiana</i>, suggesting to be used as a therapeutic supplement. Additional <i>in vivo </i>researches and clinical trials would be needed to justify the findings.</span></span></span></span><br> &nbsp;</div> Stevia rebaudiana,extract,wound healing property,rat. 9 17 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-81-4&slc_lang=en&sid=1 Naser Abbasi ilamfarma@gmail.com 10031947532846001110 0000000344573997 No Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran Hori ghaneialvar ghaneialvar-h@medilam.ac.ir 10031947532846001111 0000000326009161 No Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, IranDepartment of Clinical Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Sania Saneei Saneei_s@gmasil.com 10031947532846001112 0000000344225577 No Department of Dermatology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran Mohammad Mahdi zangeneh m.mehdizangeneh@yahoo.com 10031947532846001113 0000000344573997 Yes Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran akram zangeneh zanganeh-a@medilam.ac.ir 10031947532846001114 0000000181298432 No Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran