fa Bioactive Compounds پژوهشي Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="line-height:150%"><span optima="" style="font-family:"><span style="color:black"><span style="font-size:9.0pt"><span style="line-height:150%">The study assessed the hepatoprotective and therapeutic effects of methanol extract of Asystasia gangetica leaves (MEAGL) on rats induced liver injury with monosodium glutamate (MSG). In this study, fifty-four rats were selected into nine groups, with each of the groups having six rats. Group 1 was the negative control; group 2 was a positive control treated only with MSG, and group 3 was group treated with MSG + 100 mg/kg/day of silymarin. Groups 4 and 5 were extract groups administered with 200 and 500 mg/kg MEAGL/day, whereas groups 6 and 7 were hepatoprotectant groups pre-treated with 200 and 500 mg/kg MEAGL/day before MSG administration. Groups 8 and 9 were the therapeutic groups first treated with MSG and then orally administered with 200 and 500 mg/kg MEAGL/day, respectively. The positive group treated with MSG only had significantly (P< 0.05) elevated alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) activities relative to the negative control. MSG induction further caused a significant (P< 0.05) reduction in total protein and albumin concentrations and elevated total and direct bilirubin concentrations of the positive control relative to the negative control. In the groups of MEAGL pre-treated rats as well as the rats treated with MEAGL after being treated with MSG, significantly (P < 0.05) reduced ALT, AST and ALP activities and elevated total protein and albumin concentrations and improved liver architecture compared with the positive group treated only with MSG<span style="line-height:150%">,</span> were observed. The findings revealed that the MEAGL possess both hepatoprotective and therapeutic activities that could ameliorate MSG-induced hepatic disorders.</span></span></span></span></span></span><br> &nbsp;</div> Asystasia gangetica, hepatoprotection, liver functions, monosodium glutamate, liver marker enzymes, acute toxicity 1 10 http://pbp.medilam.ac.ir/browse.php?a_code=A-10-25-13&slc_lang=fa&sid=1 Robert Ikechukwu Urokoir.uroko@mouau.edu.ng 10031947532846001155 10031947532846001155 Yes Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria Agbafor Amarachi amarachi.agbafor@gmail.com 10031947532846001156 10031947532846001156 No Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria Paul Chukwuemaka Nweje-Anyalowu lukaspod@yahoo.com 10031947532846001157 10031947532846001157 No Department of Biochemistry, Faculty of Science, Clifford University, Owerrinta, Abia State, Nigeria Ogwo Elisha Uko dr.elishaogwo@yahoo.com 10031947532846001158 10031947532846001158 No Department of Physiology, Abia State University, Uturu, Abia State, Nigeria Precious Tobechi Abuachi abuchiprecous@yahoo.com 10031947532846001159 10031947532846001159 No Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria