Volume 5, Issue 1 (6-2023)
pbp 2023, 5(1): 1-7 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Zangeneh M M, Zangeneh A, Etemadi N, Tabatabaei Aghda S J, Pourkamalzadeh M, Zand S, et al . The Effect of Nano Silver Particles of the Aqueous Extract of Artemisia aucheri on the Healing Process of Skin Wounds in Rats. pbp 2023; 5 (1) :1-7
URL: http://pbp.medilam.ac.ir/article-1-189-en.html
URL: http://pbp.medilam.ac.ir/article-1-189-en.html
Mohammad Mehdi Zangeneh1 
, Akram Zangeneh1 , Navid Etemadi * 2, Seyyed Jamaleddin Tabatabaei Aghda3 , Mahtab Pourkamalzadeh3 , Samira Zand3 , Mohammad Abbaszadeh4 , Reza Asadzadeh5
, Akram Zangeneh1 , Navid Etemadi * 2, Seyyed Jamaleddin Tabatabaei Aghda3 , Mahtab Pourkamalzadeh3 , Samira Zand3 , Mohammad Abbaszadeh4 , Reza Asadzadeh5
1- Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran
2- DVM Graduate, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran , navid@ymail.com
3- Department of Microbiology, Faculty of veterinary Medicine, Urmia University, Urmia, Iran
4- Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
5- Assistant Professor of Nephrology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran
2- DVM Graduate, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran , navid@ymail.com
3- Department of Microbiology, Faculty of veterinary Medicine, Urmia University, Urmia, Iran
4- Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
5- Assistant Professor of Nephrology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran
Abstract: (749 Views)
Objectives: One of the application areas of nanobiotechnology is the use of silver nanoparticles (Nanosilver particles) for a new solution in medical treatments. In the present study, the researchers investigate the effect of nano silver particles of the aqueous extract of Artemisia aucheri on skin wound healing among male rats.
Material and Methods: After creating wounds in 48 rats, they were randomly divided into 6 groups. Treated with 0.2% AgNPs ointment, 0.2% AgSO4 ointment, 0.2% A. aucheri ointment, 3% tetracycline ointment, Eucerin basal ointment, and untreated control group. The tested groups were treated for ten days.
Results: Treatment with AgNPs ointment significantly increased the amount of vascular contraction, hexose amine and hydroxyproline, and fibrocyte and fibrocyte to fibroblast ratio. Also, in the mentioned group, the wound area and the total number of cells, neutrophils and lymphocytes decreased significantly compared to other groups.
Conclusion: The nano silver particles of the aqueous extract of A. aucheri accelerate the healing process of skin wounds and reduce the time required for complete wound healing.
Material and Methods: After creating wounds in 48 rats, they were randomly divided into 6 groups. Treated with 0.2% AgNPs ointment, 0.2% AgSO4 ointment, 0.2% A. aucheri ointment, 3% tetracycline ointment, Eucerin basal ointment, and untreated control group. The tested groups were treated for ten days.
Results: Treatment with AgNPs ointment significantly increased the amount of vascular contraction, hexose amine and hydroxyproline, and fibrocyte and fibrocyte to fibroblast ratio. Also, in the mentioned group, the wound area and the total number of cells, neutrophils and lymphocytes decreased significantly compared to other groups.
Conclusion: The nano silver particles of the aqueous extract of A. aucheri accelerate the healing process of skin wounds and reduce the time required for complete wound healing.
Type of Study: Research |
Subject:
Herbal Drugs
Received: 2023/06/11 | Accepted: 2022/12/1 | Published: 2023/05/31
Received: 2023/06/11 | Accepted: 2022/12/1 | Published: 2023/05/31
References
1. Allahtavakoli M, Khaksari Haddad M, Assar Sh. Comparison of topical application of Mummify and Phenytoin cream on skin wound healing in rat. J Babol Univ Med Sci 2003; 5(18): 7-13.
2. Asharani PV, Wu YL, Gong Z, Valiyaveettil S. Toxicity of silver nanoparticles in zebrafish models. Nanotechnology 2008; 19(25): 255102.
3. B.S. Nayak, G. Isitor, E.M. Davis, G.K. Pillai, The evidence based wound healing activity of Lawsonia inermis Linn, Phytother. Res. 21 (2007) 827–831.
4. D. Dwivedi, M. Dwivedi, S. Malviya, V. Singh, Evaluation ofwound healing, antimicrobial and antioxidant potential of Pongamia pinnata in wistar rats, J. Tradit. Complement. Med. 7 (2017) 79–85
5. Dinani NJ, Asgary A, Madani H, Naderi G, Mahzoni P. Hypocholesterolemic and antiatherosclerotic effect of artemisia aucheri in hypercholesterolemic rabbits. Pak J Pharm m Sci 2010; 23(3): 321-325.
6. Freunscht P, Van Duyne RP, Schneider S. Surface-enhanced Raman spectroscopy of trans-stilbene adsorbed on platinum- or self-assembled monolayer-modified silver film over nanosphere surfaces. Chemical Physics Letters. 1997; 281(4): 372-8.
7. G.D. Phillips, R.A. Whitehe, D.R. Kinghton, Initiation and pattern of angiogenesis in wound healing in the rats, Am. J. Anat. 192 (1991) 257–262.
8. G.F. Caetano, M. Fronza, M.N. Leite, A. Gomes, M.A.C. Frade, Comparison of collagen content in skin wounds evaluated by biochemical assay and by computeraided histomorphometric analysis, Pharm. Biol. 64 (2016) 2555–2559.
9. G.S. Lazarus, D.M. Cooper, D.R. Knighton, D.J. Margolis, R.E. Pecoraro, G. Rodeheaver, M.C. Robson, Definitions and guidelines for assessment of wounds and evaluation of healing, Arch. Dermatol. 130 (1994) 489–493.
10. H. Azhdari-Zarmehri, S. Nazemi, E. Ghasemi, Z. Musavi, Z. Tahmasebi, F. Farsad, A. Farzam, Assessment of effect of hydro-alcoholic extract of scrophularia striata on burn healing in rat, JBUMS. 16 (2014) 42–48.
11. indices of wound healing in chronic diabetic rat. J Babol Univ Med Sci 2005; 8(29): 12-21.
12. Jarrahi M, Emami Abarghuee M. Effect of Hydro-Alcoholic extract of Matricaria chamomilla L on burned wound healing in rat. J Gorgan Uni Med Sci 2008; 10(26): 22-26.
13. Jarrahi M, Zahedi M, Ajorlu M. Effect of Aloe barbadensis Miller on skin wound healing in rat. J Gorgan Uni Med Sci 2009; 11(29): 13-17.
14. Johnston DE. Wound healing in skin, plastic and reconstructive surgery. Vet Clinic North Am. 1990; 20:1-45.
15. Khaksari M, Mardani M, Rezaee zadeh A. Effect of oral ascorbic acid on histological
16. Mansour Ghanaie F, Sigaroudi S, Mobasheri HR, Jallili A. Effect of Artemisia on Asthma. Faiz 2003; 7(25): 60-63.
17. Mousavi ZB, Meshki M, Hemmati A, Veisi MS, Rafiei R. Evaluation of the efficacy of
18. Park EJ, Yi J, Kim Y, Choi K, Park K. Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism. Toxicol In Vitro 2010; 24: 872–8.
19. Quince mucilage on wound healing. Iranian J Dermatology 2006; 9(37): 260-263.
20. Rezvani ME, Roohbakhsh A, Allahtavakoli M, Shamsizadeh A. Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: possible involvement of adenosine. J Ethnopharmacol 2010; 127(2): 313-318.
21. Sadeghi Fard H, Zareian P. Survey on analgesic effect of Hydro-alcoholic extract of Artemisia aucheri in two models of acute and chronic pain. J Kordestan Univ Med Sci 2008; 13(4): 30-36.
22. Said Fernández S, Ramos Guerra MC, Mata Cárdenas BD, Vargas Villarreal J, Villarreal Treviño L. In vitro antiprotozoal activity of the leaves of Artemisia ludoviciana. Fitoterapia 2005; 76(5): 466-468.
23. Sarkar S, Jana AD, Samanta SK, Mostafa G. Facile synthesis of silver nano particles with highly efficient anti-microbial property. Polyhedron. 2007; 26: 4419-26.
24. Sewall GK, Robertson KM, Connor NP, Heisey DM, Hartig GK. Effect of topical mitomycin on skin wound contraction. Arch Facial Plast Surg. 2003;5:59-62.
25. Souba WW, Wilmore D. Diet and nutrition in case of the patient with surgery. 9th ed, Baltimore: Williams and
26. Takenaka S, Karg E, Roth C, Schulz H, Ziesenis A, Heinzmann U, et al. Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats. Environ Health Perspect. 2001 Aug; 109(4):547-51.
27. Townsend CM. Sabiston textbook of surgery. 16th ed, New York: Oxford University Prass; 2001:85-91.
28. Tsuda K, Nakatani T, Sugama J, Okuwa M, Sanada H. Influence of the timing of switching a protein-free to a protein-containing diet on the wound healing process in a rat all-layer skin defect. Int Wound J 2010; 7(3): 135-146.
29. Wilkins Press; 1999:1589-1618.
30. Yoshimaru T, Suzuki Y, Inoue T, Niide O, Ra C. Silver activates mast cells through reactive oxygen species production and a thiol-sensitive store-independent Cainflux. Free Radic Biol Med 2006; 40: 1949–59.
31. Zareian P, Zahiri Sh, Ketabchi F, Ruzmeh Sh. Effect of local Tamarix monnifera on skin wound healing process in rabbit. J Mazand Univ Med Sci 2007; 17(57): 48-57.
32. Zargari A. Herbal plants. 6th ed, Tehran: Tehran University Publisher; 1999. P 63
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |