Volume 5, Issue 2 (12-2023)
pbp 2023, 5(2): 68-85 |
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Gholami A, Karami E, Ebrahimpoorghalehjoghi S, Hajjarzadeh M, Javadi K, Bakhtiari M, et al . The therapeutic effects of Ganoderma lucidum on cancer and immune system such as Anti-Tumor, Anti-Metastatic, Antioxidant, Anti-Angiogenic, Anti-Inflammatory and Immuno-Modulating. pbp 2023; 5 (2) :68-85
URL: http://pbp.medilam.ac.ir/article-1-201-en.html
URL: http://pbp.medilam.ac.ir/article-1-201-en.html
Ali Gholami1 
, Esmail Karami2 , Sahar Ebrahimpoorghalehjoghi3 , Mehrab Hajjarzadeh4 , Kasra Javadi5 , Mehran Bakhtiari6 , Mohamad Mahjoor7 , Fatemeh Rad8 , Mahtab Mehboodi9 , Zahra Mottaghiyan * 10, Reza Akhavan-Sigari11
, Esmail Karami2 , Sahar Ebrahimpoorghalehjoghi3 , Mehrab Hajjarzadeh4 , Kasra Javadi5 , Mehran Bakhtiari6 , Mohamad Mahjoor7 , Fatemeh Rad8 , Mahtab Mehboodi9 , Zahra Mottaghiyan * 10, Reza Akhavan-Sigari11
1- School of Medicine, Arak University of Medical Sciences, Arak, Iran
2- Department of Physiology and Sports Pathology, Faculty of Sport Sciences, Arak University, Arak, Iran
3- Cellular and Molecular Biology Islamic, Azad University, Gorgan Branch, Gorgan, Iran
4- Department of Clinical Biochemistry, School of pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, Iran
5- Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran
6- MSc Student of Parasitology, Students Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
7- Department of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
8- Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
9- Department of Microbiology and Virology, Kerman University of Medical Sciences, Kerman, Iran
10- Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran , zmottaghiyan@ymail.com
11- 11 Department of Neurosurgery, University Medical Center Tuebingen, Germany 12 Department of Health Care Management and Clinical Research, Collegium Humanum Warsaw Management University Warsaw, Poland
2- Department of Physiology and Sports Pathology, Faculty of Sport Sciences, Arak University, Arak, Iran
3- Cellular and Molecular Biology Islamic, Azad University, Gorgan Branch, Gorgan, Iran
4- Department of Clinical Biochemistry, School of pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, Iran
5- Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran
6- MSc Student of Parasitology, Students Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
7- Department of Immunology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
8- Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
9- Department of Microbiology and Virology, Kerman University of Medical Sciences, Kerman, Iran
10- Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran , zmottaghiyan@ymail.com
11- 11 Department of Neurosurgery, University Medical Center Tuebingen, Germany 12 Department of Health Care Management and Clinical Research, Collegium Humanum Warsaw Management University Warsaw, Poland
Abstract: (618 Views)
Ganoderma lucidum is a fungus pertaining to the Ganodermataceae family, also known as Lingzhi in China and Reishi in Japan. The G. lucidum has been utilized to treat several illnesses, ameliorate health and longevity and it also affects the quality of life. Researches have demonstrated advantageous impacts of G. lucidum as an adjuvant treatment for cancer patients without toxicity. G. lucidum comprises different compounds, which predominantly contain, polysaccharides, triterpenoids, steroids, nucleotides, peptides, fatty acids, which augment the immune system and have effects such as anti-tumor, anti-metastatic, antioxidant, anti-angiogenic, anti-inflammatory. G. lucidum polysaccharides is the essential ingredient in the water dissolved extractives of this mushroom. Polysaccharides and triterpenoids are important because of their anti-cancer properties. Many research has been done on the therapeutic effects and identification of the chemical constituents of this valuable medicinal fungus in the world. In this article, we peruse the consequences of the researchers on the therapeutic effects of this fungus on cancer and introduce compounds reported from it. G. lucidum contains compounds, that play a significant role in the prophylaxis and treatment of cancer, activate our immune system for many defense functions. Researchers' indicate that G. lucidum has a high capacity for acceptance as healthy dietary complement for patient cancer therapy. The reason for some lack of preparation of Ganoderma as a drug may be due to problems with production. Further studies are needed to further illuminate the mechanisms of the modulatory impacts of the immune system also the direct anticancer impacts.
Received: 2023/10/28 | Accepted: 2023/12/1 | Published: 2023/12/1
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