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Volume 6, Issue 2 (7-2024)                   pbp 2024, 6(2): 1-7 | Back to browse issues page

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Saadat F, Fathi Azarbayjani A. Albumin-Loaded Nanofiber for Topical Wound Healing. pbp 2024; 6 (2) :1-7
URL: http://pbp.medilam.ac.ir/article-1-221-en.html
Albumin-Loaded Nanofiber for Topical Wound Healing
Fatemeh Saadat1 , Anahita Fathi Azarbayjani *2
1- Student Research Committee, Urmia University of Medical Sciences
2- Department of Pharmaceutics, School of Pharmacy, Urmia University of Medical Sciences , anahitaazarbayjani@yahoo.com
Abstract:   (1162 Views)

Objective: Intravenous albumin administration is known to improve blood circulation and promote wound healing, while topical albumin can inhibit bacterial growth on wounds. Additionally, topical caffeine has been reported to stimulate vascularization and enhance blood vessel formation in the skin. This study aimed to investigate, for the first time, the effect of topical albumin and caffeine individually and in combination—on wound healing rate in rat models.

Methods: Albumin- and caffeine-loaded nanofibers were fabricated using the electrospinning technique. Nanofiber morphology was characterized using scanning electron microscopy (SEM) and their chemical composition was confirmed by Fourier-transform infrared spectroscopy (FT-IR). The therapeutic effects of the prepared nanofibers were evaluated in a full-thickness excision wound model in rats.

Results: Both albumin alone and the albumin–caffeine combination significantly accelerated wound healing, with a marked reduction in the wound area compared to controls. By the end of week 2, wound contraction reached 96% in the albumin–caffeine nanofiber group, compared with 79% in the untreated control group.

Conclusion: Topical application of albumin-loaded nanofiber dressings demonstrated potent wound-healing properties, further enhanced by the addition of caffeine. These findings suggest that albumin–caffeine nanofiber dressings could represent a promising and innovative approach for accelerating wound repair.

Keywords: Albumin, caffeine, nanofiber, wound healing
Full-Text [PDF 2198 kb]   (239 Downloads)    
Type of Study: Research | Subject: Bioactive Compounds
Received: 2024/04/13 | Accepted: 2024/04/28 | Published: 2024/09/1
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