Volume 7, Issue 2 (5-2025)
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Seydi F, Soltanbeigi A, Pourrahim A, Asadzadeh R. Ethnobotanical Study of Medicinal Plants Utilized for the Management of Prostate Disorders in Abdanan city, Ilam Province, Western Iran. pbp 2025; 7 (2) :56-68
URL: http://pbp.medilam.ac.ir/article-1-242-en.html
URL: http://pbp.medilam.ac.ir/article-1-242-en.html
1- Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran
2- Faculty of Pharmacy, Basic Pharmaceutical Sciences Dep., Medicinal & Aromatic Plants, Culture & Technology, Turkey
3- Student Research Committee, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
4- Assistant Professor of Nephrology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran ,drasadzadehr@ymail.com
2- Faculty of Pharmacy, Basic Pharmaceutical Sciences Dep., Medicinal & Aromatic Plants, Culture & Technology, Turkey
3- Student Research Committee, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
4- Assistant Professor of Nephrology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran ,
Abstract: (15224 Views)
Objective: One of the common diseases among men is prostate problems, which include benign prostatic hyperplasia and prostate cancer. For centuries, medicinal plants have served as integral components in the management of prostate disorders, providing natural alternatives to conventional therapies. In this regard, using local and ethnobotanical knowledge in a region like Ilam can help to identify effective medicinal plants for these diseases. This research was conducted with the aim of identifying and investigating medicinal plants effective on the prostate in Abdanan city from an ethnobotanical point of view.
Methods: This study was conducted using a qualitative method and through semi-structured interviews with 25 traditional healers in Abdanan city (Ilam province, western Iran). The collected information included the names of the plants, how to use them, the parts of the plant used and their therapeutic effects on the prostate. Data analysis was done using quantitative analysis and qualitative content.
Results: The results showed that 10 types of medicinal plants in Abdanan city are known to be effective on prostate problems. Among the identified plants, we can mention clover, rose hip, chicory, yarrow, stinging nettle, camelthorn, flaxseed, puncture vine, borage, and hollyhock. Clover and rose hip plant with UR (usage report index) equal to 9, RFC (relative frequency of citation) equal to 0.62 and PFU (percentage of frequency of use) equal to 34.6% are the most medicinal plants used for prostate in Abdanan region.
Conclusion: The indigenous and ethnobotanical knowledge of Abdanan city shows that medicinal plants can be used as effective therapeutic supplements in the management of prostate problems. The findings suggest a potential for developing herbal-based treatments as complementary approaches.
Methods: This study was conducted using a qualitative method and through semi-structured interviews with 25 traditional healers in Abdanan city (Ilam province, western Iran). The collected information included the names of the plants, how to use them, the parts of the plant used and their therapeutic effects on the prostate. Data analysis was done using quantitative analysis and qualitative content.
Results: The results showed that 10 types of medicinal plants in Abdanan city are known to be effective on prostate problems. Among the identified plants, we can mention clover, rose hip, chicory, yarrow, stinging nettle, camelthorn, flaxseed, puncture vine, borage, and hollyhock. Clover and rose hip plant with UR (usage report index) equal to 9, RFC (relative frequency of citation) equal to 0.62 and PFU (percentage of frequency of use) equal to 34.6% are the most medicinal plants used for prostate in Abdanan region.
Conclusion: The indigenous and ethnobotanical knowledge of Abdanan city shows that medicinal plants can be used as effective therapeutic supplements in the management of prostate problems. The findings suggest a potential for developing herbal-based treatments as complementary approaches.
Received: 2024/08/25 | Accepted: 2025/02/28 | Published: 2025/02/28
References
1. Henry, G.H., Malewska, A., Joseph, D.B., Malladi, V.S., et al., A cellular anatomy of the normal adult human prostate and prostatic urethra. Cell reports, 2018. 25(12): p. 3530-3542. e5. doi: 10.1016/j.celrep.2018.11.086.
2. Isaacs, J.T., Prostatic structure and function in relation to the etiology of prostatic cancer. The Prostate, 1983. 4(4): p. 351-366. doi:10.1002/pros.2990040405.
3. Untergasser, G., S. Madersbacher, and P. Berger, Benign prostatic hyperplasia: age-related tissue-remodeling. Experimental gerontology, 2005. 40(3): p. 121-128. doi: 10.1016/j.exger.2004.12.008.
4. Leibovitz, A., Y. Baumoehl, and R. Segal, Increased incidence of pathological and clinical prostate cancer with age: age related alterations of local immune surveillance. The Journal of urology, 2004. 172(2): p. 435-437. doi:10.1097/01.ju.0000131908.19114.d3.
5. Magri, V., Boltri, M., Cai, T., Colombo, R., et al., et al., Multidisciplinary approach to prostatitis. Archivio Italiano di Urologia e Andrologia, 2018. 90(4): p. 227-248. doi:10.4081/aiua.2018.4.227.
6. Thorpe, A. and D. Neal, Benign prostatic hyperplasia. The Lancet, 2003. 361(9366): p. 1359-1367. doi:10.1016/S0140-6736(03)13073-5.
7. Roehrborn, C.G., Male lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH). Medical Clinics, 2011. 95(1): p. 87-100. doi:10.1016/j.mcna.2010.08.013.
8. Rule, A.D., M.M. Lieber, and S.J. Jacobsen, Is benign prostatic hyperplasia a risk factor for chronic renal failure? The journal of urology, 2005. 173(3): p. 691-696. doi:10.1097/01.ju.0000153518.11501.d2.
9. Krieger, J.N., Lee, S.W.H, Jeon, J., Cheah, P.Y., et al., Epidemiology of prostatitis. International journal of antimicrobial agents, 2008. 31: p. 85-90. doi:10.1016/j.ijantimicag.2007.08.028.
10. Rawla, P., Epidemiology of prostate cancer. World journal of oncology, 2019. 10(2): p. 63. doi:10.1016/j.ijantimicag.2007.08.028.
11. De Silva, F. and J. Alcorn, A tale of two cancers: A current concise overview of breast and prostate cancer. Cancers, 2022. 14(12): p. 2954. doi:10.3390/cancers14122954.
12. Culp, M.B., Soerjomataram, I., Efstathiou, J.A., Bray, F., et al., Recent global patterns in prostate cancer incidence and mortality rates. European urology, 2020. 77(1): p. 38-52. doi:10.1016/j.eururo.2019.08.005.
13. Siri, F.H. and H. Salehiniya, Prostate cancer in Iran: An epidemiological review. World Cancer Research Journal, 2019. 6: p. 1268. doi:10.32113/wcrj_20194_1268.
14. Mistry, K. and G. Cable, Meta-analysis of prostate-specific antigen and digital rectal examination as screening tests for prostate carcinoma. The Journal of the American Board of Family Practice, 2003. 16(2): p. 95-101. doi:10.3122/jabfm.16.2.95.
15. Tiruye, T., O'Callaghan, M., FitzGerald, L.M., Moretti, K., et al., Medication-based comorbidity measures and prostate cancer treatment selection. Clinical Genitourinary Cancer, 2024. 22(2): p. 599-609. e2. doi:10.1016/j.clgc.2024.01.018.
16. Yu, Z.-J., Yan, H.-L., Xu, F.-H.., Chao, H.-C., et al., Efficacy and side effects of drugs commonly used for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia. Frontiers in Pharmacology, 2020. 11: p. 658. doi:10.3389/fphar.2020.00658.
17. Welsh, T. and A. Mitchell, Centrally acting antihypertensives and alpha-blockers in people at risk of falls: therapeutic dilemmas—a clinical review. European geriatric medicine, 2023. 14(4): p. 675-682. doi:10.1007/s41999-023-00813-x.
18. Welliver, C., Butcher, M., Potini, Y., McVary, K.T., et al., Impact of alpha blockers, 5-alpha reductase inhibitors and combination therapy on sexual function. Current urology reports, 2014. 15: p. 1-8. doi:10.1007/s11934-014-0441-2.
19. Pouyan, N., Mesopotamia, the cradle of civilization and medicine. World Journal of Pharmaceutical Research, 2016. 5(4): p. 192-225. doi:10.20959/wjpr20164-5895.
20. Germer, R., Ancient Egyptian pharmaceutical plants and the eastern Mediterranean, in The healing past. 1993, Brill. p. 69-80. doi:10.1163/9789004377325.
21. Tafazoli, V., Tavakoli, A., Mosaffa-Jahromi, M., Cooley, K., et al., Approach of Persian medicine to health and disease. Advances in Integrative Medicine, 2022. 9(1): p. 3-8. doi:10.1016/j.aimed.2021.07.007.
22. Schmidt, B., Ribnicky, D.M., Poulev, A., Logendra, S., et al., A natural history of botanical therapeutics. Metabolism, 2008. 57: p. S3-S9. doi:10.1016/j.metabol.2008.03.001.
23. Nolan, J.M. and N.J. Turner, Ethnobotany: the study of people-plant relationships. Ethnobiology, 2011. 9: p. 133-147. doi:10.1002/9781118015872.
24. Heinrich, M., Ethnobotany and its role in drug development. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 2000. 14(7): p. 479-488. doi:10.1002/1099-1573(200011)14:7<479::aid-ptr958>3.0.co;2-2.
25. Razmjoue, D., Ezati, M., Abbasi, N., Pirhadi, M., et al., Ethnobotanical study of medicinal plants used by local population of Ilam city on back pain, West of Iran. Traditional and Integrative Medicine, 2024. doi:10.18502/tim.v9i3.16533.
26. Mirzaei, A., Khatami, F., Ebrahimi, M., Mousavibahar, S.H., et al., The Effect of herbal extracts on the treatment and prevention of prostate cancer: a literature review. Translational Research in Urology, 2019. 1(2): p. 67-73. doi:10.22034/tru.2020.231129.1021.
27. Nasir, A. and E. Yabalak, Exploring natural herbs: their role in treating male infertility, enhancing sexual desire and addressing urological disorders. International Journal of Environmental Health Research, 2024: p. 1-27. doi:10.1080/09603123.2024.2408417.
28. Touwaide, A., N.G. De Santo, and G. Aliotta, The origins of Western herbal medicines for kidney diseases. Advances in chronic kidney disease, 2005. 12(3): p. 251-260. doi:10.1016/j.ackd.2005.03.005.
29. Pagano, E., Laudato, M., Griffo, M. and R. Capasso, Phytotherapy of benign prostatic hyperplasia. A minireview. Phytotherapy research, 2014. 28(7): p. 949-955. doi:10.1002/ptr.5084.
30. Koch, E., Extracts from fruits of saw palmetto (Sabal serrulata) and roots of stinging nettle (Urtica dioica): viable alternatives in the medical treatment of benign prostatic hyperplasia and associated lower urinary tracts symptoms. Planta medica, 2001. 67(06): p. 489-500. doi:10.1055/s-2001-16496.
31. Ghasemi, P.A., M. Momeni, and M. Bahmani, Ethnobotanical study of medicinal plants used by Kurd tribe in Dehloran and Abdanan districts, Ilam province, Iran. African Journal of Traditional, Complementary and Alternative Medicines, 2013. 10(2): p. 368-385. doi:10.4314/ajtcam.v10i2.24.
32. Nikpour, N., Fotoohi, S., Hosseini, S.Z., Negaresh, H., et al., An assessment of land degradation and its effects on geomorphology using LADA model: a case study of Ilam Province, west of Iran. Environmental Earth Sciences, 2022. 81(10): p. 274. doi:10.1007/s12665-022-10292-1.
33. WHO. WHO global report on traditional and complementary medicine 2019. 2019; Available from: https://www.who.int/publications/i/item/978924151536.
34. Jaradat, N.A., Zaid, A.N., Al-Ramahi, R., Alqub, M..A, et al., Ethnopharmacological survey of medicinal plants practiced by traditional healers and herbalists for treatment of some urological diseases in the West Bank/Palestine. BMC Complementary and Alternative Medicine, 2017. 17: p. 1-18. doi:10.1186/s12906-017-1758-4.
35. Abbasi, N., Asadzadeh, R., Seydi, F. and M. Bahmani, Ethnobotanical Study of Medicinal Plants Used for Prostatitis in Dehloran County, Ilam Province, Western Iran. Journal of Biochemicals and Phytomedicine, 2024. 3(2): p. 20-25. doi:10.34172/jbp.2024.16.
36. Gegele, I.B., Ajayi, T.O., Attah, A.F. and J.O. Moody, Ethnobotanical Study of Plants Used in the Management of Benign Prostate Hyperplasia in Ilorin, Nigeria. Nigerian Journal of Pharmaceutical Research, 2023. 19(1): p. 47-58. doi:10.4314/njpr.v19i1.5.
37. Chika, A., Bello, S.O., Yunusa, A., Yahaya, A.B., et al., Ethnobotanical survey of medicinal plants used as remedies for benign prostatic hyperplasia in Sokoto North Western Nigeria. National Journal of Physiology, Pharmacy and Pharmacology, 2022. 12(4): p. 511-511. doi:10.5455/njppp.2022.12.01043202203032022.
38. Emmanuel, N., Ethno medicines used for treatment of prostatic disease in Foumban, Cameroon. African Journal of Pharmacy and Pharmacology, 2010. 4(11): p. 793-805. doi:10.5897/AJPP.9000136.
39. Çölgeçen, H., U. Koca, and H. Büyükkartal, Use of red clover (Trifolium pratense L.) seeds in human therapeutics, in Nuts and Seeds in Health and Disease Prevention. 2020, Elsevier. p. 421-427. doi:10.1016/B978-0-12-818553-7.00029-2.
40. Akbaribazm, M., Khazaei, F., Naseri, L., Pazhouhi, M., et al., Pharmacological and therapeutic properties of the Red Clover (Trifolium pratense L.): an overview of the new findings. Journal of Traditional Chinese Medicine, 2021. 41(4). doi:10.19852/j.cnki.jtcm.20210604.001.
41. Obranović, M., Balbino, S., Repajić, M., Robić, K., et al., Wild nettle (Urtica dioica L.) root: Composition of phytosterols and pentacyclic triterpenes upon habitat diversity. Food chemistry advances, 2023. 2: p. 100262. doi:10.1016/j.focha.2023.100262.
42. Shim, Y.Y., Gui, B., Arnison, P.G., Wang, Y., et al., Flaxseed (Linum usitatissimum L.) bioactive compounds and peptide nomenclature: A review. Trends in food science & technology, 2014. 38(1): p. 5-20. doi:10.1016/j.tifs.2014.03.011.
43. Fan, C., C. Pacier, and D.M. Martirosyan, Rose hip (Rosa canina L): A functional food perspective. Functional Foods in Health and Disease, 2014. 4(12): p. 493-509. doi:10.31989/ffhd.v4i12.159.
44. Duda, Ł., Kłosiński, K.K., Budryn, G., Jaśkiewicz, A., et al., Medicinal use of chicory (Cichorium intybus L.). Scientia Pharmaceutica, 2024. 92(2): p. 31. doi:10.3390/scipharm92020031.
45. Applequist, W.L. and D.E. Moerman, Yarrow (Achillea millefolium L.): a neglected panacea? A review of ethnobotany, bioactivity, and biomedical research. Economic Botany, 2011. 65: p. 209-225. doi:10.1007/s12231-011-9154-3.
46. Sirotkin, A.V. and A. Kolesarova, Puncture vine (Tribulus terrestris L.) in control of health and reproduction. Physiological research, 2021. 70(Suppl 4): p. S657. doi:10.33549/physiolres.934711.
47. Shaker, E., H. Mahmoud, and S. Mnaa, Anti-inflammatory and anti-ulcer activity of the extract from Alhagi maurorum (camelthorn). Food and Chemical Toxicology, 2010. 48(10): p. 2785-2790. doi:10.1016/j.fct.2010.07.007.
48. Ahmad, N., Bibi, Y., Raza, I., Zahara, K., et al., Traditional uses and pharmacological properties of Alhagi maurorum: A review. Asian Pacific Journal of Tropical Disease, 2015. 5(11): p. 856-861. doi:10.1016/S2222-1808(15)60945-8.
49. Amiri, M.-B., M. Jahan, and P. Rezvani-Moghaddam, Enhancing Phytopharmacological Compounds and Traits of Persian Borage (Echium amoenum Fisch. & Mey.) by Applying Organic Soil Amendments. Compost Science & Utilization, 2024: p. 1-14. doi:10.1080/1065657X.2024.2447694.
50. Azadeh, Z., Asgharian, S., Habtemariam, S., Lorigooini, Z., et al., A review of botanical, phytochemical, and pharmacological properties of Alcea rosea L. Future Natural Products, 2023. 9(2): p. 88-99. doi:10.34172/fnp.2210-1232.
51. Yu H, Gachmaa B, Yu J, Liang T, Uranghai X, Guo G, Xu W, Ping W, Liu J, Jukov A, Mandakh U. A comprehensive and systemic review of the Gentiana: ethnobotany, traditional applications, phytochemistry, pharmacology, and toxicology in the Mongolian Plateau. Journal of Ethnopharmacology. 2025 Mar 6:119573.
52. Vandebroek I, Stepp JR, Kunwar R, Hilgert N, Pulido Silva MT, Ladio AH, Clement CR, Ferreira Júnior WS, Towns AM, Borokini I, do Carmo RF. Upholding ethical accountability in ethnobotany and ethnobiology research. Economic Botany. 2025 May 5:1-2.
53. Begum T, Arzmi MH, Khatib A, Uddin AH, Aisyah Abdullah M, Rullah K, Mat So’ad SZ, Zulaikha Haspi NF, Nazira Sarian M, Parveen H, Mukhtar S. A review on Mitragyna speciosa (Rubiaceae) as a prominent medicinal plant based on ethnobotany, phytochemistry and pharmacological activities. Natural Product Research. 2025 Mar 19;39(6):1636-52.
54. Patti M, Aci MM, Tassone MR, Musarella CM. A review of Opuntia ficus-indica (L.) Mill. ethnobotany in Italy and North Africa. Research Journal of Ecology and Environmental Sciences. 2025;5:1111.
55. Jena N, Rout S, Mishra S, Kumar S. Evaluation of quantitative ethnobotanical uses in Mayurbhanj district, Odisha, India. Journal of Biodiversity and Conservation. 2025;9(1):1-29.
56. Fisher F, Africa C, Klaasen J, Fisher R. South African Medicinal Plants Traditionally Used for Wound Treatment: An Ethnobotanical Systematic Review. Plants. 2025 Mar 5;14(5):818.
57. Patti M, Musarella CM, Spampinato G. Ethnobotanical knowledge in Calabria (southern Italy): A summary review. Heliyon. 2025 Jan 16.
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