Volume 7, Issue 4 (12-2025)
pbp 2025, 7(4): 0-0 |
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Shamaei S, Ghaemi Sadr H. The application of plant Tagets in the biosynthesis of silver nanoparticles and studying its antimicrobial and anticancer effects. pbp 2025; 7 (4)
URL: http://pbp.medilam.ac.ir/article-1-250-en.html
URL: http://pbp.medilam.ac.ir/article-1-250-en.html
1- Assistant Professor, Department of Chemistry, Khorramabad Branch, Islamic Azad University, Khorramabad, Iran. , shabnamshamaie@gmail.com
2- Master of Chemistry, Department of Chemistry, Khorramabad Branch, Islamic Azad University,Khorramabad, Iran
2- Master of Chemistry, Department of Chemistry, Khorramabad Branch, Islamic Azad University,Khorramabad, Iran
Abstract: (141 Views)
Objective: The use of silver nanoparticles is increasing due to its unique properties. plant Tagets, a tall-based medicinal plant, is rich in bioactive compounds. The aim of this study was to investigate the anticancer and antimicrobial effects of silver nanoparticles synthesized using the aqueous extract of Jafari flower on cervical cancer (Hella), breast cancer (MCF7), and lung cancer (A549) cell lines.
Methods: The toxicity of silver nanoparticles was evaluated using the MTT assay, and the results were acceptable. The synthesized nanoparticles were confirmed using UV-Vis, SEM, and XRD analyses.
Results: The nanoparticles synthesized using the plant Tagets extract had a maximum absorption wavelength of 410 nm in the UV-Vis spectrum. The XRD and SEM patterns showed that the nanoparticles were mostly spherical in shape, with an average size in the nanometer range. The MTT results showed that the silver nanoparticles had dose- and time-dependent cytotoxic effects, significantly reducing cell viability. The IC50 values for the three cancer cell lines were 63.16, 40.19, and 63.39 µg/mL for MCF7, Hella, and A549, respectively, with the lowest IC50 value observed for cervical cancer.
Conclusion: Medicinal plants can be used in the synthesis of silver nanoparticles. Thus, silver nanoparticles have antimicrobial effects, which alter the morphology of bacterial membranes, increasing the permeability of silver nanoparticles, leading to uncontrolled penetration into cells, and ultimately causing cell death.
Methods: The toxicity of silver nanoparticles was evaluated using the MTT assay, and the results were acceptable. The synthesized nanoparticles were confirmed using UV-Vis, SEM, and XRD analyses.
Results: The nanoparticles synthesized using the plant Tagets extract had a maximum absorption wavelength of 410 nm in the UV-Vis spectrum. The XRD and SEM patterns showed that the nanoparticles were mostly spherical in shape, with an average size in the nanometer range. The MTT results showed that the silver nanoparticles had dose- and time-dependent cytotoxic effects, significantly reducing cell viability. The IC50 values for the three cancer cell lines were 63.16, 40.19, and 63.39 µg/mL for MCF7, Hella, and A549, respectively, with the lowest IC50 value observed for cervical cancer.
Conclusion: Medicinal plants can be used in the synthesis of silver nanoparticles. Thus, silver nanoparticles have antimicrobial effects, which alter the morphology of bacterial membranes, increasing the permeability of silver nanoparticles, leading to uncontrolled penetration into cells, and ultimately causing cell death.
Type of Study: Research |
Subject:
Herbal Drugs
Received: 2024/09/11 | Accepted: 2025/02/24 | Published: 2025/12/1
Received: 2024/09/11 | Accepted: 2025/02/24 | Published: 2025/12/1
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