Volume 7, Issue 4 (10-2025)
pbp 2025, 7(4): 15-16 |
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Vazifekhah S, Soleimani Mamalo A. A Review of the Most Important Medicinal Plants Effective in Gestational Diabetes: A Comprehensive Review of Their Mechanisms of Action. pbp 2025; 7 (4) :15-16
URL: http://pbp.medilam.ac.ir/article-1-296-en.html
URL: http://pbp.medilam.ac.ir/article-1-296-en.html
1- Department of Obstetrics and Gynecology, School of Medicine, Kowsar Woman's General University Hospital, Urmia University of Medical Sciences, Urmia, Iran , shabnam.vazifekhah@yahoo.com
2- Patient Safety Research Center, Clinical Research Institute, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
2- Patient Safety Research Center, Clinical Research Institute, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Abstract: (388 Views)
Objective: Gestational diabetes arises from the body's inability to effectively control blood glucose due to hormonal changes and insulin resistance, posing risks to both maternal and fetal health if left untreated. The condition is classified into two types: A1 (diet-controlled) and A2 (requiring medication or insulin). Genetic factors and obesity can also contribute to its development. The goal of this study is to provide a comprehensive review of the most important medicinal plants native to Iran that are effective in managing gestational diabetes and to explore their pharmacological mechanisms.
Methodology: For this review, searches were conducted in reputable databases such as PubMed, Scopus, SID, and Google Scholar, as well as in traditional Iranian medicine reference books, to gather relevant articles on medicinal plants that affect gestational diabetes. Medicinal plants commonly used in Iranian traditional medicine for the management of gestational diabetes were selected for review. The aim was to identify plants with the potential to manage gestational diabetes while minimizing side effects.
Results: In Iranian traditional medicine, various medicinal plants have been used to manage gestational diabetes, including cinnamon, borage, fenugreek, barberry, valerian, thyme, mint, lemon balm, green cumin, ginger, green tea, barley, bitter melon, olive, sage, neem, nettle, walnut, eggplant, jujube, beans, lentils, bananas, pumpkin, sesame, mustard, coconut, and ginger. These plants are considered among the most significant for managing gestational diabetes in Iranian traditional medicine.
Conclusion: Gestational diabetes is a common condition during pregnancy that requires precise and effective management to prevent serious complications for both the mother and the fetus. In Iranian traditional medicine, numerous medicinal plants have been recognized as complementary treatments for gestational diabetes. The use of these plants can serve as a natural, cost-effective solution alongside standard medical treatments, particularly in cases of gestational diabetes. However, it is essential that the consumption of these plants is supervised by a healthcare provider to prevent potential side effects and drug interactions.
Methodology: For this review, searches were conducted in reputable databases such as PubMed, Scopus, SID, and Google Scholar, as well as in traditional Iranian medicine reference books, to gather relevant articles on medicinal plants that affect gestational diabetes. Medicinal plants commonly used in Iranian traditional medicine for the management of gestational diabetes were selected for review. The aim was to identify plants with the potential to manage gestational diabetes while minimizing side effects.
Results: In Iranian traditional medicine, various medicinal plants have been used to manage gestational diabetes, including cinnamon, borage, fenugreek, barberry, valerian, thyme, mint, lemon balm, green cumin, ginger, green tea, barley, bitter melon, olive, sage, neem, nettle, walnut, eggplant, jujube, beans, lentils, bananas, pumpkin, sesame, mustard, coconut, and ginger. These plants are considered among the most significant for managing gestational diabetes in Iranian traditional medicine.
Conclusion: Gestational diabetes is a common condition during pregnancy that requires precise and effective management to prevent serious complications for both the mother and the fetus. In Iranian traditional medicine, numerous medicinal plants have been recognized as complementary treatments for gestational diabetes. The use of these plants can serve as a natural, cost-effective solution alongside standard medical treatments, particularly in cases of gestational diabetes. However, it is essential that the consumption of these plants is supervised by a healthcare provider to prevent potential side effects and drug interactions.
Type of Study: Review/Systemtic review |
Subject:
Phytochemistry
Received: 2024/12/16 | Accepted: 2025/05/29 | Published: 2025/01/29
Received: 2024/12/16 | Accepted: 2025/05/29 | Published: 2025/01/29
References
1. Boroumand F, Ghayur S, Gharaaghaji R, Vazifekhah S. Efficacy of prophylactic use of metformin in prevention of gestational diabetes mellitus in nondiabetic obese pregnant women. J Obstet Gynecol Cancer Res. 2022;7(6):524–9.
2. McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P. Gestational diabetes mellitus. Nat Rev Dis Primers. 2019;5(1):47. doi: 10.1038/s41572-019-0098-8.
3. Buchanan TA, Xiang AH. Gestational diabetes mellitus. J Clin Invest. 2005;115(3):485–91.
4. Coustan DR. Gestational diabetes mellitus. Clin Chem. 2013;59(9):1310–21.
5. Buchanan TA, Xiang A, Kjos SL, Watanabe R. What is gestational diabetes?. Diabetes Care. 2007;30(Suppl 2): 105. doi: 10.2337/dc07-s201.
6. Rad AH, Abbasalizadeh S, Vazifekhah S, Abbasalizadeh F, Hassanalilou T, Bastani P, et al. The future of diabetes management by healthy probiotic microorganisms. Curr Diabetes Rev. 2017;13(6):582–9.
7. Ryan EA. Diagnosing gestational diabetes. Diabetologia. 2011;54(3):480–6. doi: 10.1007/s00125-010-2005-4.
8. Kampmann U, Madsen LR, Skajaa GO, Iversen DS, Moeller N, Ovesen P. Gestational diabetes: a clinical update. World J Diabetes. 2015;6(8):1065. doi: 10.4239/wjd.v6.i8.1065.
9. Kjos SL, Buchanan TA. Gestational diabetes mellitus. N Engl J Med. 1999;341(23):1749–56.
10. Kjos SL, Buchanan TA. Gestational diabetes mellitus. N Engl J Med. 1999;341(23):1749–56.
11. Reece EA, Leguizamón G, Wiznitzer A. Gestational diabetes: the need for a common ground. Lancet. 2009;373(9677):1789–97.
12. Mecacci F, Lisi F, Vannuccini S, Ottanelli S, Rambaldi MP, Serena C, et al. Different gestational diabetes phenotypes: which insulin regimen fits better?. Front Endocrinol. 2021;12:630903. https://doi.org/10.3389/fendo.2021.630903
13. Persson B, Stangenberg M, Hansson U, Nordlander E. Gestational diabetes mellitus (GDM): comparative evaluation of two treatment regimens, diet versus insulin and diet. Diabetes. 1985;34(Suppl 2):101–5.
14. Cheung NW. The management of gestational diabetes. Vasc Health Risk Manag. 2009;5:153–64.
15. Xu YX, Xi S, Qian X. Evaluating traditional Chinese medicine and herbal products for the treatment of gestational diabetes mellitus. J Diabetes Res. 2019;2019:9182595.
16. Vazifekhah S. The Most Effective Medicinal Plants for Toxoplasmosis-Induced Miscarriage and of Their Mechanisms of Action. Plant Biotechnol Persa. 2025;7(3):0–0.
17. Yessoufou A, Gbenou J, Grissa O, Hichami A, Simonin AM, Tabka Z, et al. Anti-hyperglycemic effects of three medicinal plants in diabetic pregnancy: modulation of T cell proliferation. BMC Complement Altern Med. 2013;13:1–3. doi: 10.1186/1472-6882-13-77.
18. Arista DM, Amelia R, Fitriani D, Khotimah H, Ratnaningrum SD, Irwanto Y, et al. Gestational Diabetes Mellitus: An overview and its potential treatment with herbs. GSC Biol Pharm Sci. 2023;23(3):261–73.
19. Bernstein N, Akram M, Yaniv‐Bachrach Z, Daniyal M. Is it safe to consume traditional medicinal plants during pregnancy?. Phytother Res. 2021;35(4):1908–24. doi: 10.1002/ptr.6935.
20. Aghili Khorasani MH. Qarabadin-e-Kabir. Tehran: Research Institute for Islamic and Complementary Medicine, Tehran University of Medical Sciences; 2009.
21. Avicenna. The Canon of Medicine (Al-Qanun fi al-Tibb). Translated by Laleh Bakhtiar. Chicago: Kazi Publications; 1999.
22. Arzani MA. Tebb-e-Akbari. Tehran: Research Institute for Islamic and Complementary Medicine, Tehran University of Medical Sciences; 2008.
23. Momen Tonekaboni H. Tohfat al-Momenin. Tehran: Nashr-e Shahr; 2007.
24. Zargari A. Medicinal Plants. Tehran: Tehran University Press; 1992.
25. Jorjani SE. Zakhireh Kharazmshahi (Treasure of Kharazm Shah). Tehran: Iranian Academy of Medical Sciences; 2001.
26. Ghaznavi H. Traditional Iranian Medicine and Medicinal Plants. Tehran: Nashr-e Elm; 2011.
27. Khorasani M, Najmabadi M. Medicinal Plants of Iran. Tehran: Tehran University Press; 2006.
28. Sadr E. Encyclopedia of Medicinal Plants. Tehran: Jangal Publishing House; 2010.
29. Mir Heidar H. Plant Sciences and Medicinal Herbs of Iran. Tehran: Islamic Culture Press; 1993.
30. Nazem Javedan M. Kholasat al-Hikmah (Summary of Wisdom). Tehran: Institute of Traditional Medicine and Materia Medica Research; 2012.
31. Dehkhoda A. Dehkhoda Dictionary: Plant Names. Tehran: Tehran University Press; 1998.
32. Davari Ardekani A. Principles of Iranian Traditional Medicine. Tehran: University of Tehran Press; 2015.
33. Ahvazi A. Kamel al-Sanaat al-Tibbiyya. Tehran: Academy of Medical Sciences of the Islamic Republic of Iran; 2008.
34. Shams Ardakani M, Ghorbani A. Herbal Medicines in Iranian Traditional Medicine. Tehran: Medical Sciences University Press; 2015.
35. [Incomplete entry: Please provide full citation for "32"].
36. Bat'haei SZ, Makarezadeh N, Shirali S. A review on the mechanisms of action of plant bioactive compounds in the treatment of diabetes mellitus. Herbal Plants. 2012;11(44):1–24. Available from: https://sid.ir/paper/15171/fajv
37. Fallah Huseini H, Fakhrzadeh H, Larijani B, Shikh Samani A. Review of anti-diabetic medicinal plant used in traditional medicine. J Med Plants. 2006;5(S2):1–8. Available from: http://jmp.ir/article-1-583-en.html
38. Fallah Hosseini H, Fakhrzadeh H, Ardestani Larijani MB, Sheikh Samani AH. A review of medicinal plants used in diabetes. Herbal Plants. 2005;5(Special Issue on Diabetes):1–8. Available from: https://sid.ir/paper/15205/fa
39. Fallah B, Mehrabbeik A, Salmani N. A Review of Clinical Trial Studies on Medicinal Plants in the Treatment of Diabetes. Int J Diabetes Obes. 2022;14(2):117–30.
40. Mohammadi E, Abdi F. Medicinal Plants Effective on Diabetes in Northwest of Iran. Plant Biotechnol Persa. 2025;7(1):4–9.
41. Labbafi M, Mohammadi T, Babaei A, Abbasi S, Avazzadeh A, Khalaj H, et al. An overview of documented medicinal plants used for the treatment of diabetes in Iran with ethnobotanical and evolutionary perspective (2002–2022). Ethnobot Res Appl. 2024;29:1–53. Available from: https://ethnobotanyjournal.org/index.php/era/article/view/6387
42. Rashidi AA, Mirhashemi SM, Taghizadeh M, Sarkhail P. Iranian medicinal plants for diabetes mellitus: a systematic review. Pak J Biol Sci. 2013;16(9):401–11. doi: 10.3923/pjbs.2013.401.411
43. Bahmani M, Zargaran A, Rafieian-Kopaei M, Saki K. [Title of the article]. Asian Pac J Trop Med. 2014;7(Suppl 1): 348–S354.
44. Yedjou CG. The management of diabetes mellitus using medicinal plants and vitamins. Int J Mol Sci. 2023;24(10):9085. doi: 10.3390/ijms24109085
45. Mahmud Hussen B, Noori M, Sayad B, Ebadi Fard Azar M, Sadri Nahand J, Bayat M, Babaei F, Karampour R, Bokharaei-Salim F, Mirzaei H, Moghoofei M. New potential MicroRNA biomarkers in human immunodeficiency virus elite controllers, human immunodeficiency virus infections, and coinfections with hepatitis B virus or hepatitis C virus. Intervirology. 2023 Dec 20;66(1):122–135.
46. Ghanbari A, Nouri M, Darvishi M. Evaluation of relationship between serum hemoglobin A1C level and severity of diabetic foot ulcers based on Wagner criteria. J Med Chem Sci. 2023;6:2234–2241.
47. Darvishi M, Nouri M, Zahir M, Asli M, Hejripoor SZ, Karimi E. Overview of human papillomavirus infection. Infect Disord Drug Targets. 2024 Mar 1;24(2):65–76.
48. Nouri M, Kamakifar P, Khodabandehlou N, Nahand JS, Tavakoli A, Norooznezhad F, Sorayyayi S, Babaei F, Mostafaei S, Moghoofei M. Association between Parvovirus B19 and anemia in HIV-infected patients. Med J Islam Repub Iran. 2019 Dec 16;33:137.
49. Darvishi M, Noori M, Nazer MR, Soleiman-Meigooni S, Forootan M. The relationship between Helicobacter pylori and extra-gastrointestinal infections. Iran J Med Microbiol. 2020 Nov 10;14(6):543–565.
50. Darvishi M, Hashemi Rafsanjani SMR, Nouri M, Abbaszadeh S, Heidari-Soureshjani S, Kasiri K, Rahimian G. Biological mechanisms of polyphenols against Clostridium difficile: A systematic review. Infect Disord Drug Targets. 2025 May;25(3): 18715265313944. doi: 10.2174/0118715265313944240726115600
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