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Hajiesmaello M, Mohammadi E. Herbal Agents for Weight Loss and Anti-Obesity: A Review of Traditional Iranian Medicine. pbp 2026; 8 (In press)
URL: http://pbp.medilam.ac.ir/article-1-345-en.html
URL: http://pbp.medilam.ac.ir/article-1-345-en.html
1- Palliative Care Research Center, Ur.C., Islamic Azad University, Urmia, Iran
2- Department of Internal Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran ,dremohammadi90@gmail.com
2- Department of Internal Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran ,
Abstract: (20 Views)
Introduction: Obesity and the accumulation of fat in the abdominal and flank regions are major public health challenges. Beyond aesthetic concerns, they significantly increase the risk of chronic metabolic and cardiovascular diseases. Traditional Iranian medicine (TIM) offers a natural and complementary approach to obesity management through a diverse array of medicinal plants. This review aims to identify and summarize the most prominent and frequently used herbal remedies for controlling and treating abdominal and flank obesity in classical TIM sources.
Methods: This study was conducted as a literature review of classical TIM manuscripts and authoritative herbal medicine references focused on obesity management. Complementary searches were performed in recognized scientific databases, including ISC, SID, PubMed, Google Scholar, and Magiran, using Persian and English keywords related to "medicinal plants," "obesity," and "abdominal and flank fat." Relevant articles and online sources were gathered and analyzed to provide a comprehensive overview of effective herbal interventions.
Results: The findings reveal that a wide variety of medicinal plants demonstrate significant effects on weight reduction and obesity control. Zingiberaceae such as ginger, turmeric, and cardamom; Lamiaceae like thyme, savory, and rosemary; and Apiaceae including celery, ajwain, cumin, and fennel were found to enhance metabolism and reduce fat accumulation. Asteraceae species such as chamomile and yarrow improve digestion and regulate blood sugar, while legumes including peanuts, soy, and fenugreek contribute to appetite suppression. Additionally, Rosaceae plants like apple, rose, and damask rose provide antioxidant compounds, and other plants such as mustard, khakshir, saffron, barberry, black seed, garlic, and lemon balm also demonstrate anti-obesity effects through diverse mechanisms.
Conclusion: This review highlights that TIM offers a broad spectrum of medicinal plants effective in weight reduction and obesity management. Proposed mechanisms include increased basal metabolism, inhibition of fat absorption, and improved gastrointestinal function. Nonetheless, definitive evidence regarding their efficacy and safety requires well-designed, large-scale clinical trials.
Methods: This study was conducted as a literature review of classical TIM manuscripts and authoritative herbal medicine references focused on obesity management. Complementary searches were performed in recognized scientific databases, including ISC, SID, PubMed, Google Scholar, and Magiran, using Persian and English keywords related to "medicinal plants," "obesity," and "abdominal and flank fat." Relevant articles and online sources were gathered and analyzed to provide a comprehensive overview of effective herbal interventions.
Results: The findings reveal that a wide variety of medicinal plants demonstrate significant effects on weight reduction and obesity control. Zingiberaceae such as ginger, turmeric, and cardamom; Lamiaceae like thyme, savory, and rosemary; and Apiaceae including celery, ajwain, cumin, and fennel were found to enhance metabolism and reduce fat accumulation. Asteraceae species such as chamomile and yarrow improve digestion and regulate blood sugar, while legumes including peanuts, soy, and fenugreek contribute to appetite suppression. Additionally, Rosaceae plants like apple, rose, and damask rose provide antioxidant compounds, and other plants such as mustard, khakshir, saffron, barberry, black seed, garlic, and lemon balm also demonstrate anti-obesity effects through diverse mechanisms.
Conclusion: This review highlights that TIM offers a broad spectrum of medicinal plants effective in weight reduction and obesity management. Proposed mechanisms include increased basal metabolism, inhibition of fat absorption, and improved gastrointestinal function. Nonetheless, definitive evidence regarding their efficacy and safety requires well-designed, large-scale clinical trials.
Type of Study: Review/Systemtic review |
Subject:
Phytomedicine
Received: 2025/08/29 | Accepted: 2025/08/30 | Published: 2026/01/20
Received: 2025/08/29 | Accepted: 2025/08/30 | Published: 2026/01/20
References
1. Kopelman PG. Obesity as a medical problem. Nature. 2000 Apr;404(6778):635-43.
2. Brewer CJ, Balen AH. Focus on obesity. Reproduction. 2010;140(3):347-64.
3. Singh P, Somers VK, Romero-Corral A, Sert-Kuniyoshi FH, Pusalavidyasagar S, Davison DE, Jensen MD. Effects of weight gain and weight loss on regional fat distribution1. The American journal of clinical nutrition. 2012 Jul 3;96(2):229.
4. Ozelci A, Romsos DR, Leveille GA. Influence of initial food restriction on subsequent body weight gain and body fat accumulation in rats. The Journal of Nutrition. 1978 Nov 1;108(11):1724-32.
5. Wright SM, Aronne LJ. Causes of obesity. Abdominal Radiology. 2012 Oct;37(5):730-2.
6. Masood B, Moorthy M. Causes of obesity: a review. Clinical Medicine. 2023 Jul 1;23(4):284-91.
7. 7. Omer TA. The causes of obesity: an in-depth review. Adv Obes Weight Manag Control. 2020 Jul;10(4):90-4.
8. Kordik CP, Reitz AB. Pharmacological treatment of obesity: therapeutic strategies. Journal of medicinal chemistry. 1999 Jan 28;42(2):181-201.
9. Fernández-López JA, Remesar X, Foz M, Alemany M. Pharmacological approaches for the treatment of obesity. Drugs. 2002 Apr;62(6):915-44.
10. Halpern A, Mancini MC. Treatment of obesity: an update on anti‐obesity medications. Obesity reviews. 2003 Feb;4(1):25-42.
11. Engin A. The definition and prevalence of obesity and metabolic syndrome. Obesity and lipotoxicity. 2017 Jun 6:1-7.
12. Golden SH, Robinson KA, Saldanha I, Anton B, Ladenson PW. Prevalence and incidence of endocrine and metabolic disorders in the United States: a comprehensive review. The Journal of Clinical Endocrinology & Metabolism. 2009 Jun 1;94(6):1853-78.
13. Bonora E, Kiechl S, Willeit J, Oberhollenzer F, Egger G, Targher G, Alberiche M, Bonadonna RC, Muggeo M. Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. Diabetes. 1998 Oct 1;47(10):1643-9.
14. Fock KM, Khoo J. Diet and exercise in management of obesity and overweight. Journal of gastroenterology and hepatology. 2013 Dec;28:59-63.
15. Pranoto NW, Fauziah V, Anugrah S, Fitriady G, Setyawan H, Geantă VA, Sibomana A, Ndayisenga J. The effectiveness of diet and exercise in the management of obesity. Retos: nuevas tendencias en educación física, deporte y recreación. 2024(58):951-9.
16. Olateju IV, Opaleye-Enakhimion T, Udeogu JE, Asuquo J, Olaleye KT, Osa E, Oladunjoye AF. A systematic review on the effectiveness of diet and exercise in the management of obesity. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2023 Apr 1;17(4):102759.
17. Zhang CH, Sheng JQ, Xie WH, Luo XQ, Xue YN, Xu GL, Chen C. Mechanism and basis of traditional Chinese medicine against obesity: prevention and treatment strategies. Frontiers in Pharmacology. 2021 Mar 8;12:615895.
18. Xu L, Zhao W, Wang D, Ma X. Chinese medicine in the battle against obesity and metabolic diseases. Frontiers in physiology. 2018 Jul 6;9:850.
19. Bahmani M, Eftekhari Z, Saki K, Fazeli-Moghadam E, Jelodari M, Rafieian-Kopaei M. Obesity phytotherapy: review of native herbs used in traditional medicine for obesity. Journal of evidence-based complementary & alternative medicine. 2016 Jul;21(3):228-34.
20. Saad B. Prevention and treatment of obesity-related inflammatory diseases by edible and medicinal plants and their active compounds. Immuno. 2022 Oct 20;2(4):609-29.
21. de Freitas Junior LM, de Almeida Jr EB. Medicinal plants for the treatment of obesity: ethnopharmacological approach and chemical and biological studies. American journal of translational research. 2017 May 15;9(5):2050.
22. Hasani-Ranjbar S, Jouyandeh Z, Abdollahi M. A systematic review of anti-obesity medicinal plants-an update. Journal of Diabetes & Metabolic Disorders. 2013 Jun 19;12(1):28.
23. Avicenna. The Canon of Medicine. Tehran: Tehran University Press; 2005.
24. Ghaffari F. Iranian Traditional Medicine: Principles and Practice. Shiraz: Shiraz University Press; 2010.
25. 25. Mozaffarian V. Iranian Medicinal Plants. Tehran: Tehran University Press; 2013.
26. Aghili MH. Makhzan al-Advieh (The Storehouse of Medicaments). Tehran: Iranian Academy of Medical Sciences; 2008.
27. Zarshenas MM, Izadi-Darbandi A, Moein M. Traditional Iranian Medicine and Herbal Pharmacotherapy. Tehran: Samt Press; 2016.
28. Zargari A. Medicinal Plants. Tehran: Tehran University Press; 1990.
29. Sadeghi S, Shams-Ardekani MR. Encyclopedia of Iranian Traditional Medicine: Herbal Remedies. Mashhad: Mashhad University Press; 2014.
30. Khorasani E. The Book of Herbs in Persian Medicine. Isfahan: Isfahan University Press; 2012.
31. Najafi T, Zarshenas MM. Iranian Traditional Medicine: Herbal Formulations and Applications. Tehran: Islamic Azad University Press; 2015.
32. Razi M. Al-Hawi fi al-Tibb (Comprehensive Book of Medicine). Tehran: Iran University Press; 2006
33. Mohammadi M, Rahimi J, Taheri S, Tizabi Z. Obesity and overweight: treatment with medicinal plants. J Iran Trad Med. 2017;8(3): 324-344.
34. Saeidbakht S. Overweight and obesity treatment using medicinal plants. J Iran Trad Med. 2010;3(6): 1-23.
35. Hosseini SA. A review of the interactive effects of exercise and medicinal plants on glycemic indices and lipid profile in diabetes mellitus. JGUMS. 2021;30(3):178-193. doi:10.32598/JGUMS.30.3.940.2. Available from: http://journal.gums.ac.ir/article-1-2351-fa.html
36. Pakmehr M, Haghighi MJ, Taheri T, Rahdar Z. A review of medicinal plants used in the treatment of obesity and overweight. Iran J Trad Med [Internet]. 2017;8(3):323-334. Available from: https://sid.ir/paper/507601/fa
37. Smetanina K. The current market of pharmacological drugs for the prevention and treatment of obesity in Ukraine: A review. Journal of Biochemicals and Phytomedicine. 2023; 2(2): 32–39. doi: 10.34172/jbp.2023.8.
38. Dastyar N, Ahmadi M. An ethnobotanical study of medicinal plants administered for the treatment of hyperlipidemia in Bushehr, South Iran. Journal of Biochemicals and Phytomedicine. 2022; 1(1): 26–30. doi: 10.34172/jbp.2022.7.
39. Hooshmand Garehbagh L, Tahmasebi M. A review of medicinal plants used for the treatment of hyperlipidemia: an ethnobotanical survey in southern Iran. Prog Biol Pharm [Internet]. 2025;7(3):49-57. Available from: http://pbp.medilam.ac.ir/article-1-285-en.html
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