Volume 8, Issue 4 And Pre-proof (9-2026)
pbp 2026, 8(4 And Pre-proof): 0-0 |
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Sepahdar A, Estabraghi F, marzban A, Karkhane M, Mehrnia M, shakib P et al . Antibacterial and Antibiofilm Effects of Green Copper Oxide Nanoparticles Synthesized using Cotoneaster Extract against Enterococcus faecalis. pbp 2026; 8 (4)
URL: http://pbp.medilam.ac.ir/article-1-441-en.html
URL: http://pbp.medilam.ac.ir/article-1-441-en.html
Asma Sepahdar1 
, Farhad Estabraghi2 , Abdolrazagh Marzban3 , Maryam Karkhane3 , Mohammad Mehrnia4 , Pegah Shakib *5 , Mahmoud Bahmani6
, Farhad Estabraghi2 , Abdolrazagh Marzban3 , Maryam Karkhane3 , Mohammad Mehrnia4 , Pegah Shakib *5 , Mahmoud Bahmani6
1- Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran2School of Dentistry, Lorestan University of Medical Sciences, Khorramabad, Iran
2- School of Dentistry, Lorestan University of Medical Sciences, Khorramabad, Iran
3- Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
4- Lorestan Agricultural and Natural Resources Research and Education Center, Agricultural Research Education and Extention Organization, Khorramabad, Iran
5- Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran ,shakib.pegah@yahoo.com
6- Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran
2- School of Dentistry, Lorestan University of Medical Sciences, Khorramabad, Iran
3- Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
4- Lorestan Agricultural and Natural Resources Research and Education Center, Agricultural Research Education and Extention Organization, Khorramabad, Iran
5- Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran ,
6- Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran
Abstract: (14 Views)
Objective: In nanotechnology, nanoparticles (NPs) are nowadays recognized as a beneficial tool for dental treatments. Metal NPs, especially copper oxide (CuO) NPs, have the potential for preventing and treating bacterial dental infections. This study was designed to assess the antimicrobial efficacy of CuO NPs synthesized using the aqueous extract of Cotoneaster plant against biofilm-producing Enterococcus faecalis.
Methods: For this purpose, we used the extract of the aforesaid plant and a green method to synthesize CuO NPs. The NPs synthesized herein were assessed using FTIR, XRD, UV-Vis, and SEM. Likewise, their antimicrobial and antibiofilm effects against E. faecalis were examined using the microdilution method. Results: NPs were found to have sizes of 20-100 nm, in addition to having a monoclinic crystal structure. The synthesized NPs and chlorhexidine displayed minimum inhibitory concentrations of 1.25 μg/mL and 31.25 μg/mL, respectively. In antibiofilm testing, the NPs led to a relative reduction in biofilm formation and bacterial growth.
Conclusion: Overall, our findings suggest that green-synthesized CuO NPs derived from Cotoneaster extract could be a suitable option for controlling microbial infections due to their strong antimicrobial and antibiofilm effects.
Methods: For this purpose, we used the extract of the aforesaid plant and a green method to synthesize CuO NPs. The NPs synthesized herein were assessed using FTIR, XRD, UV-Vis, and SEM. Likewise, their antimicrobial and antibiofilm effects against E. faecalis were examined using the microdilution method. Results: NPs were found to have sizes of 20-100 nm, in addition to having a monoclinic crystal structure. The synthesized NPs and chlorhexidine displayed minimum inhibitory concentrations of 1.25 μg/mL and 31.25 μg/mL, respectively. In antibiofilm testing, the NPs led to a relative reduction in biofilm formation and bacterial growth.
Conclusion: Overall, our findings suggest that green-synthesized CuO NPs derived from Cotoneaster extract could be a suitable option for controlling microbial infections due to their strong antimicrobial and antibiofilm effects.
Keywords: Enterococcus faecalis, metal nanoparticles, anti-biofilm properties, Antibacterial properties, green-synthesized nanoparticles
Type of Study: Research |
Subject:
Green Chemistry
Received: 2026/08/30 | Accepted: 2026/09/18 | Published: 2026/09/28
Received: 2026/08/30 | Accepted: 2026/09/18 | Published: 2026/09/28
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