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Volume 6, Issue 1 (6-2024)                   pbp 2024, 6(1): 64-53 | Back to browse issues page


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Amrollahi-Sharifabadi M, Kamalpour M, Rezaei Orimi J, Aghabeiglooei Z, alimi-Sabour E S, Abdelaziz S. Potential usage of Ruta graveolens L. in ophthalmology. pbp 2024; 6 (1) :64-53
URL: http://pbp.medilam.ac.ir/article-1-208-en.html
1- Department of Basic Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran. 5th Kilometer of Khorramabad-Boroujerd Highway Khoramabad, Lorestan, 68151-44316 Iran. E-mail: amrollahi.m@lu.ac.ir, ORCID: 0000-0002-4458-7689 , amrollahi.m@lu.ac.ir
2- Department of Basic Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, IranORCID: 0000-0001-6431-7056
3- 3Pre-hospital Emergency Medical Services and Disaster Management Center, Mazandaran University of Medical Sciences, Sari, Iran. E-mail: Rezaei.history93@gmail.com, ORCID: 0000-0002-2356-5552& Department of Persian Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
4- Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran. ORCID: 0000-0001-8467-4202
5- Department of Pharmacognosy and Traditional Pharmacy, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran. ORCID: 0000-0002-5315-2126
6- 7Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, 44519 Zagazig, Egypt. ORCID: 0000-0001-9475-6121
Abstract:   (239 Views)
Objective: There has been growing interest in medicinal plants due to their therapeutic properties in safe lower doses, despite their unpleasant smell, bitter taste, and toxicity in higher doses. Ruta graveolens L., commonly known as the herb of grace, common rue, rue, ruda, sodab, fijen, and al-suzab is a potential therapeutic candidate with variable healing properties and traditional uses. One of its lesser-known uses is in the treatment of eye conditions. The current study aimed to investigate the ophthalmological potential of Ruta graveolens L. using available scientific literature.
Methods: To this end, we extensively searched Scopus, Science Direct, Web of Science, Embase, PubMed, Google Scholar, IranMedex, SID, and Magiran for related literature on the cultural, historical and scientific aspects of Ruta graveolens L. and ophthalmology. Also, traditional Persian medicine books including Al-Qanun Fi Al-Tibb, Al-Hawi Fi Al-Tibb, Al-Abniya, and Ikhtiyarat Badiei thoroughly searched to find the potential application of rue in ophthalmology.
Results:  Our historical, literary, and traditional medicine data revealed that R. graveolens L. used in the ophthalmic field probably due to its beneficial effects in the past. Also, there are some modern studies elucidated the beneficial effects of this plant in ophthalmology.
Conclusion:  This study suggests that R. graveolens L. plant can be a promising ophthalmic drug due to its specific ocular benefits warranting further research with modern technologies.
 
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Type of Study: Review/Systemtic review | Subject: Phytomedicine
Received: 2023/12/3 | Accepted: 2024/01/18 | Published: 2024/06/4

References
1. Altememy D. Blurred vision and medicinal plants. Journal of Biochemicals and Phytomedicine. 2024; 3(1): 3-4. doi: 10.34172/jbp.2024.2.
2. Colucci-D’Amato L, Cimaglia G. Ruta graveolens as a potential source of neuroactive compounds to promote and restore neural functions. Journal of Traditional and Complementary Medicine. 2020;10(3):309-314. https://linkinghub.elsevier.com/retrieve/pii/S2225411020301632
3. Ríos J-L, Andújar I. Apoptotic activities of Mediterranean plants. The Mediterranean Diet: Elsevier; 2020. p. 565-578. https://doi.org/10.1016/B978-0-12-818649-7.00049-7
4. Stein SA. The Queen of Herbs: A Plant's-Eye View of the Sephardic Diaspora. Jewish Quarterly Review. 2022;112(2):119-138. https://doi.org/10.1353/jqr.2022.0004
5. Gibson D. Ruta graveolens, a study. British Homeopathic Journal. 1965;54(03):176-179. https://doi.org/10.1016/S0007-0785(65)80006-0
6. Wilmer WH. The blindness of Milton. Bulletin of the Institute of the History of Medicine. 1933;1(3):85-106. https://www.jstor.org/stable/44437008
7. Shayanfar J, Ghasemi H, Esmaili SS, et al. Useful Medicinal Plants for Vision Impairment in Traditional Iranian Medicine. Galen Medical Journal. 2019;8:e1285. DOI:10.31661/gmj.v8i0.1285
8. Edriss H, Rosales BN, Nugent C, et al. Islamic medicine in the middle ages. Elsevier; 2017. p. 223-229. DOI: 10.1016/j.amjms.2017.03.021
9. Furniss D, Adams T. Herb of grace: an unusual cause of phytophotodermatitis mimicking burn injury. Journal of burn care & research. 2007;28(5):767-769. https://doi.org/10.1097/BCR.0B013E318148CB82
10. Fu PP, Xia Q, Zhao Y, et al. Phototoxicity of herbal plants and herbal products. Journal of Environmental Science and Health, Part C. 2013;31(3):213-255. https://doi.org/10.1080/10590501.2013.824206
11. Ganeshpurkar A, Saluja AK. The pharmacological potential of rutin. Saudi pharmaceutical journal. 2017;25(2):149-164. http://dx.doi.org/10.1016/j.jsps.2016.04.025
12. Gentile MT, Russo R, Pastorino O, et al. Ruta graveolens water extract inhibits cell-cell network formation in human umbilical endothelial cells via MEK-ERK1/2 pathway. Experimental Cell Research. 2018;364(1):50-58. https://doi.org/10.1016/j.yexcr.2018.01.025
13. Bohuslavizki KH, Hinck-kneip C, Kneip A, et al. Reduction of MS-related scotomata by a new class of potassium channel blockers from Ruta graveolens. Neuro-ophthalmology. 1993;13(4):191-198. DOI: 10.1016/j.pharmthera.2005.10.006. https://doi.org/10.3109/01658109309038150
14. Sathye SS. Effect of homoeopathic preparation of Ruta graveolens on the progression of childhood myopia before, during and after cessation of treatment: A retrospective study. 2017. DOI:10.4103/ijrh.ijrh_72_16
15. Sina I. Al-qanun fi al-tibb [the canon of medicine]. Beirut, Lebonan: Alaalami Library. 2005.
16. Al-Razi MbZ. Al-hawi fi al-tibb. Beirut: Dar Ihya'al-Turauh al-‘Arabi. 2002.
17. Heravi M. Al Abnieh an Haghaiegh al Advieh. Corrected by Bahmanyar A Tehran: Tehran University publication. 1985.
18. Ansari Shirazi AiHZ-e-A. Ketab Ekhtiarat Badiei. 15th AD.
19. Mohanraj K, Karthikeyan BS, Vivek-Ananth R, et al. IMPPAT: A curated database of I ndian M edicinal P lants, P hytochemistry A nd T herapeutics. Scientific reports. 2018;8(1):4329. DOI:10.1038/s41598-018-22631-z
20. Vivek-Ananth R, Mohanraj K, Sahoo AK, et al. IMPPAT 2.0: an enhanced and expanded phytochemical atlas of Indian medicinal plants. ACS omega. 2023;8(9):8827-8845. https://doi.org/10.1021/acsomega.3c00156.

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