Volume 8 - Pre-proof (Accepted manuscript)
pbp 2026, 8 - Pre-proof (Accepted manuscript): 93-97 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Dalili A, Roosta Y, Ranjbari A. Successfulness of Hair Follicular Transplantation for Melanocytes Activation in Vitiligo. pbp 2026; 8 :93-97
URL: http://pbp.medilam.ac.ir/article-1-211-en.html
URL: http://pbp.medilam.ac.ir/article-1-211-en.html
1- Department of General Surgery, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2- Department of Internal Medicine, Faculty of Medicine, University of Medical Sciences, Urmia, Iran
3- Department of General Surgery, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran ,aliranjbari58@gmail.com
2- Department of Internal Medicine, Faculty of Medicine, University of Medical Sciences, Urmia, Iran
3- Department of General Surgery, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran ,
Abstract: (2253 Views)
Objective: Vitiligo is a common skin disorder characterized by depigmented patches. Despite multiple treatment options, outcomes are often unsatisfactory, particularly in patients with stable vitiligo. This study aimed to evaluate the efficacy of healthy hair follicle transplantation (FUT) for treating segmental or stable vitiligo.
Methods: This prospective study included all eligible patients with stable vitiligo in nonglabrous regions who were referred to the dermatology department of Urmia Imam Khomeini Hospital from March 2021 to February 2022. Patients underwent comprehensive evaluation to document the number, size, location, and type of vitiligo lesions. Treatment outcomes were assessed by both subjective and objective measures, focusing on reduction in lesion size and improvements in associated leukotrichia.
Results: Among 57 patients, 20 (35%) were male and 37 (65%) female, with a mean age of 29.2 ± 4.4 years. Excellent repigmentation was observed in 31 patients (54.8%), good in 18 (32.2%), fair in 5 (8.2%), and poor in 3 (4.8%). Excellent color match was achieved in 54 patches (94.7%). Perifollicular repigmentation was <2 mm in 6 patients (10%), 2–4 mm in 33 patients (57.9%), and 5–10 mm in 18 patients (31.6%).
Conclusion: FUT is a safe and effective approach for localized and segmental vitiligo, particularly in hair-bearing areas. While labor-intensive, it promotes rapid recovery, minimal morbidity, and excellent color match, supporting its use as a reliable therapeutic option
Methods: This prospective study included all eligible patients with stable vitiligo in nonglabrous regions who were referred to the dermatology department of Urmia Imam Khomeini Hospital from March 2021 to February 2022. Patients underwent comprehensive evaluation to document the number, size, location, and type of vitiligo lesions. Treatment outcomes were assessed by both subjective and objective measures, focusing on reduction in lesion size and improvements in associated leukotrichia.
Results: Among 57 patients, 20 (35%) were male and 37 (65%) female, with a mean age of 29.2 ± 4.4 years. Excellent repigmentation was observed in 31 patients (54.8%), good in 18 (32.2%), fair in 5 (8.2%), and poor in 3 (4.8%). Excellent color match was achieved in 54 patches (94.7%). Perifollicular repigmentation was <2 mm in 6 patients (10%), 2–4 mm in 33 patients (57.9%), and 5–10 mm in 18 patients (31.6%).
Conclusion: FUT is a safe and effective approach for localized and segmental vitiligo, particularly in hair-bearing areas. While labor-intensive, it promotes rapid recovery, minimal morbidity, and excellent color match, supporting its use as a reliable therapeutic option
Type of Study: Research |
Subject:
Phytomedicine
Received: 2024/02/3 | Accepted: 2024/02/5 | Published: 2024/02/6
Received: 2024/02/3 | Accepted: 2024/02/5 | Published: 2024/02/6
References
1. Verma R, Grewal R, Chatterjee M, Pragasam V, Vasudevan B, Mitra D. A comparative study of efficacy of cultured versus non cultured melanocyte transfer in the management of stable vitiligo. Medical Journal Armed Forces India. 2014;70(1):26-31. doi: 10.1016/j.mjafi.2013.09.004.
2. Yaghoobi R, Omidian M, Bagherani N. Vitiligo: a review of the published work. The Journal of dermatology. 2011;38(5):419-31. 10.1111/j.346-8138.2010.01139.x.
3. Moghadam PM, Rasouli SR, Gheybi F, Karimi E, Sahebkar AH. A Comprehensive Review on Present and Future of Pharmacotherapy of Vitiligo Disease and Potential Therapeutic Strategies. Phytomedicine Plus. 2023:100437. doi.org/10.1016/j.phyplu.2023.
4. Shokeen D. Management of vitiligo patients with surgical interventions. Cutis. 2016;97(5):E27-E9. PMID: 27274556.
5. Janowska A, Dini V, Panduri S, Macchia M, Oranges T, Romanelli M. Epidermal skin grafting in vitiligo: a pilot study. International Wound Journal. 2016;13(S3):47-51. doi: 10.1111/iwj.12632.
6. Moreno A. Camouflage of Vitiligo by Medical Tattooing. Current problems in dermatology. 2022;56:187-96. doi: 10.1159/000521486. Epub 2023 Jun 1.
7. Elias BLF, Ferreira FR, Lima EMAd, Amarante CF, Mandelbaum MHS. Grafting by epidermal scraping in stable vitiligo: a therapeutic option. Surgical and Cosmetic Dermatology. 2016;2016;8(2): 2195. doi.org/10.5935/scd1984-8773.201682760.
8. Silpa-Archa N, Griffith JL, Huggins RH, Henderson MD, Kerr HA, Jacobsen G, et al. Long-term follow-up of patients undergoing autologous noncultured melanocyte-keratinocyte transplantation for vitiligo and other leukodermas. Journal of the American Academy of Dermatology. 2017;77(2):318-27. doi: 10.1016/j.jaad.2017.01.056.
9. van Geel N, Goh BK, Wallaeys E, De Keyser S, Lambert J. A review of non-cultured epidermal cellular grafting in vitiligo. Journal of cutaneous and aesthetic surgery. 2011;4(1):17. doi: 0.4103/0974-2077.79181. .
10. Gan EY, Kong YL, Tan WD, Thng ST, Goh BK. Twelve-month and sixty-month outcomes of noncultured cellular grafting for vitiligo. Journal of the American Academy of Dermatology. 2016;75(3):564-71. doi: 10.1016/j.jaad.2016.04.007.
11. Sacchidanand S, Thakur P, Purohit V, Sujaya S. Follicular unit extraction as a therapeutic option for vitiligo. Journal of Cutaneous and Aesthetic Surgery. 2013;6(4):229. doi: 10.4103/0974-2077.123413.
12. Thakur P, Sacchidanand S, Nataraj H, Savitha A. A study of hair follicular transplantation as a treatment option for vitiligo. Journal of Cutaneous and Aesthetic Surgery. 2015;8(4):211. doi: 10.4103/0974-2077.172192. .
13. Vogel JE, Jimenez F, Cole J, Keene SA, Harris JA, Barrera A, et al. Hair restoration surgery: the state of the art. Aesthetic surgery journal. 2013;33(1):128-51. doi: 10.1177/1090820X12468314.
14. Bellei B, Papaccio F, Picardo M. Regenerative Medicine-Based Treatment for Vitiligo: An Overview. Biomedicines. 2022;10(11):2744. https://doi.org/10.3390/biomedicines10112744. .
15. Parsad D, Gupta S. Standard guidelines of care for vitiligo surgery. Indian journal of dermatology, venereology and leprology. 2008;74:37. PMID: 18688102.
16. 16. Shi H-X, Zhang R-Z, Xu B, Xu C-X, Li D, Wang L, et al. Experimental study and clinical observations of autologous hair follicle cell transplants to treat stable vitiligo. Indian Journal of Dermatology, Venereology and Leprology. 2020;86:124. DOI: 10.4103/ijdvl.IJDVL_261_18.
17. Li H, Fan L, Zhu S, Shin MK, Lu F, Qu J, et al. Epilation induces hair and skin pigmentation through an EDN3/EDNRB-dependent regenerative response of melanocyte stem cells. Scientific reports. 2017;7(1):7272. doi.org/10.1038/s41598-017-07683-x.
19. Lamoria A, Agrawal A, Rao P, Kachhawa D. A comparative study between follicular unit transplantation and autologous non-cultured non-trypsinized epidermal cells grafting (Jodhpur technique) in stable vitiligo. Journal of Cutaneous and Aesthetic Surgery. 2020;13(3):204. doi: 10.4103/JCAS.JCAS_189_19.
20. Frączek A, Kasprowicz-Furmańczyk M, Placek W, Owczarczyk-Saczonek A. Surgical treatment of vitiligo. International Journal of Environmental Research and Public Health. 2022;19(8):4812. doi: 10.3390/ijerph19084812. .
21. Birlea SA, Costin GE, Roop DR, Norris DA. Trends in regenerative medicine: repigmentation in vitiligo through melanocyte stem cell mobilization. Medicinal research reviews. 2017;37(4):907-35. doi: 10.1002/med.21426.
22. Cichorek M, Wachulska M, Stasiewicz A, Tymińska A. Skin melanocytes: biology and development. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2013;30(1):30-41. doi: 10.5114/pdia.2013.33376.
23. Kumar A, Mohanty S, Sahni K, Kumar R, Gupta S. Extracted hair follicle outer root sheath cell suspension for pigment cell restoration in vitiligo. Journal of Cutaneous and Aesthetic Surgery. 2013;6(2):121. doi: 10.4103/0974-2077.112679. .
24. Kumar R, Prajapati SK, Singh SK, Gupta AK. A prospective observational study of follicular unit excision grafting for the management of stable vitiligo. Int J Res Dermatol. 2019;5:706-10. DOI: http://dx.doi.org/10.18203/issn.2455-4529.
25. Lei T-C, J. Hearing V. Deciphering skin re-pigmentation patterns in vitiligo: an update on the cellular and molecular events involved. Chinese Medical Journal. 2020;133(10):1231-8. DOI: 10.097/CM9.0000000000000794.
26. Pillai J, Goyal N. Repigmentation of segmental vitiligo with scalp and pubic follicular unit extraction graft transplantation. International Journal of Trichology. 2023;15(2):70-3. Doi:10.4103/ijt.ijt_41_22.
27. Mohanty S, Kumar A, Dhawan J, Sreenivas V, Gupta S. Noncultured extracted hair follicle outer root sheath cell suspension for transplantation in vitiligo. British Journal of Dermatology. 2011;164(6):1241-6. doi: 10.111/j.365-2133.011.10234.x.
28. Ghasemi M, Bajouri A, Shafiiyan S, Aghdami N. Hair follicle as a source of pigment-producing cells for treatment of vitiligo: an alternative to epidermis? Tissue Engineering and Regenerative Medicine. 2020;17:815-27. doi: 10.1007/s13770-020-00284-2.
29. Alikhan A, Felsten LM, Daly M, Petronic-Rosic V. Vitiligo: a comprehensive overview: part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. Journal of the American Academy of Dermatology. 2011;65(3):473-91. doi.org/10.1016/j.jaad.2010.11.061.
30. Zhang Y, Cai Y, Shi M, Jiang S, Cui S, Wu Y, et al. The prevalence of vitiligo: a meta-analysis. PloS one. 2016;11(9):e0163806. doi: 10.1371/journal.pone..
31. Sawant NS, Vanjari NA, Khopkar U. Gender differences in depression, coping, stigma, and quality of life in patients of vitiligo. Dermatology research and practice. 2019;2019:2019:6879412. doi: 10.1155/2019/.
32. Patil S, Gautam M, Nadkarni N, Saboo N, Godse K, Setia MS. Gender differences in clinicoepidemiological features of vitiligo: a cross-sectional analysis. International Scholarly Research Notices. 2014;2014:doi: 10.1155/2014/186197.
33. Tsadik AG, Legesse GF, Desta DM, Assefa BT, Kidanemariam HG, Gidey MT. Clinico-Epidemiological Profile and Treatment Pattern of Vitiligo in Selected Dermatological Clinics of Mekelle City, Northern Ethiopia. Dermatology research and practice. 2020;2020.
34. Na GY, Seo SK, Choi SK. Single hair grafting for the treatment of vitiligo. Journal of the American Academy of Dermatology. 1998;38(4):580-4. doi: 10.1016/s0190-9622(98)70121-5.
35. Kumaresan M. Single-hair follicular unit transplant for stable vitiligo. Journal of Cutaneous and Aesthetic Surgery. 2011;4(1):41. doi: 10.4103/0974-2077.79191.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |