Volume 7, Issue 2 (5-2025)
pbp 2025, 7(2): 93-97 |
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Dalili A, Roosta Y, Ranjbari A. Successfulness of Hair Follicular Transplantation for melanocytes activation in Vitiligo. pbp 2025; 7 (2) :93-97
URL: http://pbp.medilam.ac.ir/article-1-211-en.html
URL: http://pbp.medilam.ac.ir/article-1-211-en.html
1- Department of General Surgery, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2- Department of Internal Medicine, Faculty of Medicine, University of Medical Sciences, Urmia, Iran
3- Department of General Surgery, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran ,aliranjbari58@gmail.com
2- Department of Internal Medicine, Faculty of Medicine, University of Medical Sciences, Urmia, Iran
3- Department of General Surgery, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran ,
Abstract: (1008 Views)
Background: Vitiligo is a prevalent skin condition characterized by depigmented patches on the skin of affected individuals. Despite the existence of numerous treatment alternatives, the results often prove dissatisfactory, particularly for patients with stable vitiligo. This study aimed to examine the impact of healthy hair follicular Transplantation (FUT) as a treatment method for segmental/stabilized vitiligo.
Methods: This prospective study included all eligible patients with stable vitiligo in nonglabrous parts of the body who referred to dermatology department of Urmia Imam Khomeini hospital to be treated from March 2021 to Februery 2022. The selected patients underwent a comprehensive examination to determine the number of lesions, their size, location, and type of vitiligo. The reduction in the size of vitiligo patches, along with improvements in associated leukotrichia, were evaluated using both subjective and objective assessments.
Results: Of 57 patients, 20 (35 %) were males and 37 (65 %) were females with mean age of 29.2 (4.4) years old. Thirty-one (54.8 %) patients showed excellent repigmentation. Eighteen (32.2 %) showed good repigmentation. Five (8.2 %) of the patches showed fair repigmentation. Three (4.8%) of the patches showed poor repigmentation. Additionally Excellent color match was achieved in 54 patches (94.73%). Only 6 (10%) patients had a lower than 2 mm repigmented area around the hair follicle cell transplants. Additionally, thirty-three patients (57.89%) had a 2-4 mm repigmented area around the hair follicle cell transplants. Eighteen patients (31.58 %) had had a 5-10 mm repigmented area around the hair follicle cell transplants.
Conclusion: FUT is a secure and efficacious approach to address localized and segmental vitiligo, particularly on areas of the skin with hair. While it requires significant labor, it has been observed to facilitate speedy patient recovery, entail minimal morbidity, and achieve favorable color harmony.
Methods: This prospective study included all eligible patients with stable vitiligo in nonglabrous parts of the body who referred to dermatology department of Urmia Imam Khomeini hospital to be treated from March 2021 to Februery 2022. The selected patients underwent a comprehensive examination to determine the number of lesions, their size, location, and type of vitiligo. The reduction in the size of vitiligo patches, along with improvements in associated leukotrichia, were evaluated using both subjective and objective assessments.
Results: Of 57 patients, 20 (35 %) were males and 37 (65 %) were females with mean age of 29.2 (4.4) years old. Thirty-one (54.8 %) patients showed excellent repigmentation. Eighteen (32.2 %) showed good repigmentation. Five (8.2 %) of the patches showed fair repigmentation. Three (4.8%) of the patches showed poor repigmentation. Additionally Excellent color match was achieved in 54 patches (94.73%). Only 6 (10%) patients had a lower than 2 mm repigmented area around the hair follicle cell transplants. Additionally, thirty-three patients (57.89%) had a 2-4 mm repigmented area around the hair follicle cell transplants. Eighteen patients (31.58 %) had had a 5-10 mm repigmented area around the hair follicle cell transplants.
Conclusion: FUT is a secure and efficacious approach to address localized and segmental vitiligo, particularly on areas of the skin with hair. While it requires significant labor, it has been observed to facilitate speedy patient recovery, entail minimal morbidity, and achieve favorable color harmony.
Type of Study: Research |
Subject:
Phytomedicine
Received: 2024/02/3 | Accepted: 2024/02/5 | Published: 2024/02/6
Received: 2024/02/3 | Accepted: 2024/02/5 | Published: 2024/02/6
References
1. Verma R, Grewal R, Chatterjee M, Pragasam V, Vasudevan B, Mitra D. A comparative study of efficacy of cultured versus non cultured melanocyte transfer in the management of stable vitiligo. Medical Journal Armed Forces India. 2014;70(1):26-31. doi: 10.1016/j.mjafi.2013.09.004.
2. Yaghoobi R, Omidian M, Bagherani N. Vitiligo: a review of the published work. The Journal of dermatology. 2011;38(5):419-31. 10.1111/j.346-8138.2010.01139.x.
3. Moghadam PM, Rasouli SR, Gheybi F, Karimi E, Sahebkar AH. A Comprehensive Review on Present and Future of Pharmacotherapy of Vitiligo Disease and Potential Therapeutic Strategies. Phytomedicine Plus. 2023:100437. doi.org/10.1016/j.phyplu.2023.
4. Shokeen D. Management of vitiligo patients with surgical interventions. Cutis. 2016;97(5):E27-E9. PMID: 27274556.
5. Janowska A, Dini V, Panduri S, Macchia M, Oranges T, Romanelli M. Epidermal skin grafting in vitiligo: a pilot study. International Wound Journal. 2016;13(S3):47-51. doi: 10.1111/iwj.12632.
6. Moreno A. Camouflage of Vitiligo by Medical Tattooing. Current problems in dermatology. 2022;56:187-96. doi: 10.1159/000521486. Epub 2023 Jun 1.
7. Elias BLF, Ferreira FR, Lima EMAd, Amarante CF, Mandelbaum MHS. Grafting by epidermal scraping in stable vitiligo: a therapeutic option. Surgical and Cosmetic Dermatology. 2016;2016;8(2): 2195. doi.org/10.5935/scd1984-8773.201682760.
8. Silpa-Archa N, Griffith JL, Huggins RH, Henderson MD, Kerr HA, Jacobsen G, et al. Long-term follow-up of patients undergoing autologous noncultured melanocyte-keratinocyte transplantation for vitiligo and other leukodermas. Journal of the American Academy of Dermatology. 2017;77(2):318-27. doi: 10.1016/j.jaad.2017.01.056.
9. van Geel N, Goh BK, Wallaeys E, De Keyser S, Lambert J. A review of non-cultured epidermal cellular grafting in vitiligo. Journal of cutaneous and aesthetic surgery. 2011;4(1):17. doi: 0.4103/0974-2077.79181. .
10. Gan EY, Kong YL, Tan WD, Thng ST, Goh BK. Twelve-month and sixty-month outcomes of noncultured cellular grafting for vitiligo. Journal of the American Academy of Dermatology. 2016;75(3):564-71. doi: 10.1016/j.jaad.2016.04.007.
11. Sacchidanand S, Thakur P, Purohit V, Sujaya S. Follicular unit extraction as a therapeutic option for vitiligo. Journal of Cutaneous and Aesthetic Surgery. 2013;6(4):229. doi: 10.4103/0974-2077.123413.
12. Thakur P, Sacchidanand S, Nataraj H, Savitha A. A study of hair follicular transplantation as a treatment option for vitiligo. Journal of Cutaneous and Aesthetic Surgery. 2015;8(4):211. doi: 10.4103/0974-2077.172192. .
13. Vogel JE, Jimenez F, Cole J, Keene SA, Harris JA, Barrera A, et al. Hair restoration surgery: the state of the art. Aesthetic surgery journal. 2013;33(1):128-51. doi: 10.1177/1090820X12468314.
14. Bellei B, Papaccio F, Picardo M. Regenerative Medicine-Based Treatment for Vitiligo: An Overview. Biomedicines. 2022;10(11):2744. https://doi.org/10.3390/biomedicines10112744. .
15. Parsad D, Gupta S. Standard guidelines of care for vitiligo surgery. Indian journal of dermatology, venereology and leprology. 2008;74:37. PMID: 18688102.
16. 16. Shi H-X, Zhang R-Z, Xu B, Xu C-X, Li D, Wang L, et al. Experimental study and clinical observations of autologous hair follicle cell transplants to treat stable vitiligo. Indian Journal of Dermatology, Venereology and Leprology. 2020;86:124. DOI: 10.4103/ijdvl.IJDVL_261_18.
17. Li H, Fan L, Zhu S, Shin MK, Lu F, Qu J, et al. Epilation induces hair and skin pigmentation through an EDN3/EDNRB-dependent regenerative response of melanocyte stem cells. Scientific reports. 2017;7(1):7272. doi.org/10.1038/s41598-017-07683-x.
19. Lamoria A, Agrawal A, Rao P, Kachhawa D. A comparative study between follicular unit transplantation and autologous non-cultured non-trypsinized epidermal cells grafting (Jodhpur technique) in stable vitiligo. Journal of Cutaneous and Aesthetic Surgery. 2020;13(3):204. doi: 10.4103/JCAS.JCAS_189_19.
20. Frączek A, Kasprowicz-Furmańczyk M, Placek W, Owczarczyk-Saczonek A. Surgical treatment of vitiligo. International Journal of Environmental Research and Public Health. 2022;19(8):4812. doi: 10.3390/ijerph19084812. .
21. Birlea SA, Costin GE, Roop DR, Norris DA. Trends in regenerative medicine: repigmentation in vitiligo through melanocyte stem cell mobilization. Medicinal research reviews. 2017;37(4):907-35. doi: 10.1002/med.21426.
22. Cichorek M, Wachulska M, Stasiewicz A, Tymińska A. Skin melanocytes: biology and development. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2013;30(1):30-41. doi: 10.5114/pdia.2013.33376.
23. Kumar A, Mohanty S, Sahni K, Kumar R, Gupta S. Extracted hair follicle outer root sheath cell suspension for pigment cell restoration in vitiligo. Journal of Cutaneous and Aesthetic Surgery. 2013;6(2):121. doi: 10.4103/0974-2077.112679. .
24. Kumar R, Prajapati SK, Singh SK, Gupta AK. A prospective observational study of follicular unit excision grafting for the management of stable vitiligo. Int J Res Dermatol. 2019;5:706-10. DOI: http://dx.doi.org/10.18203/issn.2455-4529.
25. Lei T-C, J. Hearing V. Deciphering skin re-pigmentation patterns in vitiligo: an update on the cellular and molecular events involved. Chinese Medical Journal. 2020;133(10):1231-8. DOI: 10.097/CM9.0000000000000794.
26. Pillai J, Goyal N. Repigmentation of segmental vitiligo with scalp and pubic follicular unit extraction graft transplantation. International Journal of Trichology. 2023;15(2):70-3. Doi:10.4103/ijt.ijt_41_22.
27. Mohanty S, Kumar A, Dhawan J, Sreenivas V, Gupta S. Noncultured extracted hair follicle outer root sheath cell suspension for transplantation in vitiligo. British Journal of Dermatology. 2011;164(6):1241-6. doi: 10.111/j.365-2133.011.10234.x.
28. Ghasemi M, Bajouri A, Shafiiyan S, Aghdami N. Hair follicle as a source of pigment-producing cells for treatment of vitiligo: an alternative to epidermis? Tissue Engineering and Regenerative Medicine. 2020;17:815-27. doi: 10.1007/s13770-020-00284-2.
29. Alikhan A, Felsten LM, Daly M, Petronic-Rosic V. Vitiligo: a comprehensive overview: part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. Journal of the American Academy of Dermatology. 2011;65(3):473-91. doi.org/10.1016/j.jaad.2010.11.061.
30. Zhang Y, Cai Y, Shi M, Jiang S, Cui S, Wu Y, et al. The prevalence of vitiligo: a meta-analysis. PloS one. 2016;11(9):e0163806. doi: 10.1371/journal.pone..
31. Sawant NS, Vanjari NA, Khopkar U. Gender differences in depression, coping, stigma, and quality of life in patients of vitiligo. Dermatology research and practice. 2019;2019:2019:6879412. doi: 10.1155/2019/.
32. Patil S, Gautam M, Nadkarni N, Saboo N, Godse K, Setia MS. Gender differences in clinicoepidemiological features of vitiligo: a cross-sectional analysis. International Scholarly Research Notices. 2014;2014:doi: 10.1155/2014/186197.
33. Tsadik AG, Legesse GF, Desta DM, Assefa BT, Kidanemariam HG, Gidey MT. Clinico-Epidemiological Profile and Treatment Pattern of Vitiligo in Selected Dermatological Clinics of Mekelle City, Northern Ethiopia. Dermatology research and practice. 2020;2020.
34. Na GY, Seo SK, Choi SK. Single hair grafting for the treatment of vitiligo. Journal of the American Academy of Dermatology. 1998;38(4):580-4. doi: 10.1016/s0190-9622(98)70121-5.
35. Kumaresan M. Single-hair follicular unit transplant for stable vitiligo. Journal of Cutaneous and Aesthetic Surgery. 2011;4(1):41. doi: 10.4103/0974-2077.79191.
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