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Asghari R, Mohammadi S. Anti-Influenza Medicinal Plants: A Phytotherapeutic Review of Mechanisms and Efficacy. pbp 2025; 7 (In press)
URL: http://pbp.medilam.ac.ir/article-1-273-en.html
URL: http://pbp.medilam.ac.ir/article-1-273-en.html
1- Department of Internal Medicine, School of Medicine, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran
2- Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran ,sm9589920@gmail.com
2- Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran ,
Abstract: (711 Views)
Objective: Influenza is a common viral infection that affects the respiratory system, causing symptoms such as fever, cough, sore throat, and body aches. Given the limitations of conventional treatments and their potential side effects, phytotherapy, or treatment with medicinal plants, has gained attention as a complementary approach for managing this illness. This study aims to review the therapeutic effects of medicinal plants that are effective against influenza and analyze their mechanisms of action based on traditional medicine teachings and scientific evidence.
Methods: In this review study, key terms such as influenza, traditional medicine, medicinal plants, and treatment were searched in databases including Google Scholar, SID, Magiran, and Scopus. Irrelevant articles were excluded, and relevant articles were used for the literature review.
Results: Several medicinal plants, including turmeric, ginger, echinacea, and peppermint, are used in traditional medicine for treating cold and flu. The most common plant families are Lamiaceae (26.1%) and Asteraceae (17.4%). The main therapeutic properties are antiviral (39.1%) and immune-boosting (34.8%), followed by anti-inflammatory and symptom-relieving effects (26.1%). Other properties, like antimicrobial and sedative effects, were less common.
Conclusion: This study highlights the potential of medicinal plants in managing and treating influenza. Given the widespread nature of the disease and its disruptive symptoms, phytotherapy can complement conventional treatments, helping to reduce illness severity and accelerate recovery. The findings suggest that these plants are a safe and effective option, especially for high-risk groups like children. However, further clinical studies are needed to confirm their safety, efficacy, and optimal dosage and administration methods.
Methods: In this review study, key terms such as influenza, traditional medicine, medicinal plants, and treatment were searched in databases including Google Scholar, SID, Magiran, and Scopus. Irrelevant articles were excluded, and relevant articles were used for the literature review.
Results: Several medicinal plants, including turmeric, ginger, echinacea, and peppermint, are used in traditional medicine for treating cold and flu. The most common plant families are Lamiaceae (26.1%) and Asteraceae (17.4%). The main therapeutic properties are antiviral (39.1%) and immune-boosting (34.8%), followed by anti-inflammatory and symptom-relieving effects (26.1%). Other properties, like antimicrobial and sedative effects, were less common.
Conclusion: This study highlights the potential of medicinal plants in managing and treating influenza. Given the widespread nature of the disease and its disruptive symptoms, phytotherapy can complement conventional treatments, helping to reduce illness severity and accelerate recovery. The findings suggest that these plants are a safe and effective option, especially for high-risk groups like children. However, further clinical studies are needed to confirm their safety, efficacy, and optimal dosage and administration methods.
Received: 2024/11/7 | Accepted: 2025/01/19 | Published: 2025/05/31
References
1. Hutchinson EC. Influenza virus. Trends Microbiol. 2018;26(9):809–10. doi: 10.1016/j.tim.2018.05.013.
2. Kilbourne ED. Influenza. New York: Springer Science & Business Media; 2012.
3. Potter CW. A history of influenza. J Appl Microbiol. 2001;91(4):572–9.
4. Cannell JJ, Zasloff M, Garland CF, Scragg R, Giovannucci E. On the epidemiology of influenza. Virol J. 2008;5:1–12. doi: 10.1186/1743-422X-5-29.
5. Zambon MC. Epidemiology and pathogenesis of influenza. J Antimicrob Chemother. 1999;44(Suppl_2):3–9. doi: 10.1093/jac/44.suppl_2.3.
6. Suarez DL. Influenza A virus. In: Animal Influenza. 2016. p. 1–30.
7. Webster RG. Influenza: an emerging disease. Emerg Infect Dis. 1998;4(3):436.
8. Kilbourne ED. Influenza pandemics of the 20th century. Emerg Infect Dis. 2006;12(1):9. doi: 10.3201/eid1201.051254.
9. Hussain M, Galvin HD, Haw TY, Nutsford AN, Husain M. Drug resistance in influenza A virus: the epidemiology and management. Infect Drug Resist. 2017;10:121–34. doi: 10.2147/IDR.S105473.
10. Palese P. Influenza: old and new threats. Nat Med. 2004;10(Suppl 12): 82–7.
11. Akram M, Tahir IM, Shah SMA, Mahmood Z, Altaf A, Ahmad K, et al. Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review. Phytother Res. 2018;32(5): 811–22.
12. Rajasekaran D, Palombo EA, Chia Yeo T, Lim Siok Ley D, Lee Tu C, Malherbe F, et al. Identification of traditional medicinal plant extracts with novel anti-influenza activity. PLoS One. 2013;8(11): 79293. https://doi.org/10.1371/journal.pone.0079293
13. Adetunji CO, Ajayi OO, Akram M, Olaniyan OT, Chishti MA, Inobeme A, et al. Medicinal plants used in the treatment of influenza A virus infections. In: Medicinal Plants for Lung Diseases: A Pharmacological and Immunological Perspective. 2021. p. 417–35.
14. Mehrbod P, Abdalla MA, Njoya EM, Ahmed AS, Fotouhi F, Farahmand B, et al. South African medicinal plant extracts active against influenza A virus. BMC Complement Altern Med. 2018;18:1–10.
15. Avicenna. The Canon of Medicine. Grant DP, translator. New York: AMS Press; 1999.
16. Najmabadi M. History of Persian Medicine. Tehran: Iran University of Medical Sciences Press; 2013.
17. Jorjani A. Zakhireh Khwarazmshahi (The Treasure of Khwarazmshah). Ghaffari M, translator. Tehran: Tehran University Press; 2005.
18. Kermani S. Traditional Iranian Herbal Medicine. Tehran: Rasa Publications; 2016.
19. Razi M. Al-Hawi (The Comprehensive Book). Barjasteh R, translator. Tehran: Tabriz University Press; 2010.
20. Khorsand M, Haghshenas S. Medicinal Plants in Iranian Traditional Medicine. Tehran: Shahed University Press; 2011.
21. Tayarani-Najaran Z, Zargari A. Pharmacognosy and Medicinal Plants in Iranian Traditional Medicine. Tehran: Tehran University Press; 2014.
22. Faridi P. Traditional Persian Medicine. Tehran: Institute for the History of Science and Technology; 2013.
23. Saeedian R. Herbal Medicines in Persian Traditional Pharmacology. Tehran: Tarbiat Modares University Press; 2015.
24. Shams-Ardekani M, Jafari M. The Role of Iranian Herbal Medicine in Modern Treatment Methods. Tehran: PNU Press; 2017.
25. Bakhru H. Herbs That Heal: Medicinal Plants in Persian Medicine. Tehran: Arya Press; 2010.
26. Mokhlesi Z. The Medicinal Plants of Iran. Tehran: Islamic Azad University Press; 2018.
27. Ghaffari M. Persian Materia Medica: Medicinal Plants of Iran. Tehran: University of Medical Sciences Press; 2009.
28. Ebrahimi S, Sahebkar A. Herbal Therapy in Iranian Traditional Medicine. Tehran: Razi Medical Sciences University Press; 2020.
29. Wang X, Jia W, Zhao A, Wang X. Anti‐influenza agents from plants and traditional Chinese medicine. Phytother Res. 2006;20(5):335–41. doi: 10.1002/ptr.1892.
30. Dao TT, Nguyen PH, Won HK, Kim EH, Park J, Won BY, et al. Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases. Food Chem. 2012;134(1):21–8.
31. Ahmed I, Aslam A, Mustafa G, Masood S, Ali MA, Nawaz M. Anti-avian influenza virus H9N2 activity of aqueous extracts of Zingiber officinalis (Ginger) and Allium sativum (Garlic) in chick embryos. Pak J Pharm Sci. 2017;30(4):1341–4. PMID: 29039335
32. Fusco D, Liu X, Savage C, Taur Y, Xiao W, Kennelly E, et al. Echinacea purpurea aerial extract alters course of influenza infection in mice. Vaccine. 2010;28(23):3956–62. doi: 10.1016/j.vaccine.2010.03.047.
33. Abou Baker DH, Amarowicz R, Kandeil A, Ali MA, Ibrahim EA. Antiviral activity of Lavandula angustifolia L. and Salvia officinalis L. essential oils against avian influenza H5N1 virus. J Agric Food Res. 2021;4:100135.
34. Protsenko MA, Mazurkova NA, Filippova EI, Kukushkina TA, Lobanova IE, Pshenichkina YA, et al. Anti-Influenza Activity of Extracts from Plants of the Lamiaceae Family. Russ J Bioorg Chem. 2022;48(7):1534–41. doi: 10.15372/KhUR2023468
35. Karimi A, Asadi-Samani M, Altememy D, Moradi MT. Anti-influenza and anti-inflammatory effects of green tea (Camellia sinensis L.) extract. Future Nat Prod. 2022;8(2):59–64. https://doi.org/10.34172/fnp.2022.10
36. Chavan RD, Shinde P, Girkar K, Madage R, Chowdhary A. Assessment of anti-influenza activity and hemagglutination inhibition of Plumbago indica and Allium sativum extracts. Pharmacogn Res. 2016;8(2):105. doi: 10.4103/0974-8490.172562
37. Priya NC, Kumari PS. Antiviral activities and cytotoxicity assay of seed extracts of Piper longum and Piper nigrum on human cell lines. Int J Pharm Sci Rev Res. 2017;44(1):197–202.
38. Karadağ AE, Biltekin SN, Ghani U, Demirci B, Demirci F. Enzyme-Based Antiviral Potential of Cinnamomum verum J. Presl. Essential Oil and Its Major Component (E)-Cinnamaldehyde. ACS Omega. 2024;9(12):14118–22. doi: 10.1021/acsomega.3c09595.
39. Pu XY, Liang JP, Wang XH, Xu T, Hua LY, Shang RF, et al. Anti-influenza A virus effect of Hypericum perforatum L. extract. Virol Sin. 2009;24:19–27.
40. Gramza-Michałowska A, Sidor A, Kulczyński B. Berries as a potential anti-influenza factor–A review. J Funct Foods. 2017;37:116–37.
41. Senchina DS, Wu L, Flinn GN, Konopka DN, McCoy JA, Widrelechner MP, et al. Year-and-a-half old, dried Echinacea roots retain cytokine-modulating capabilities in an in vitro human older adult model of influenza vaccination. Planta Med. 2006;72(13):1207–15.
42. Alexyuk PG, Bogoyavlenskiy AP, Alexyuk MS, Turmagambetova AS, Zaitseva IA, Omirtaeva ES, et al. Adjuvant activity of multimolecular complexes based on Glycyrrhiza glabra saponins, lipids, and influenza virus glycoproteins. Arch Virol. 2019;164(7):1793–803.
43. Chiru T, Fursenco C, Ciobanu N, Dinu M, Popescu E, Ancuceanu R, et al. Use of medicinal plants in complementary treatment of the common cold and influenza–perception of pharmacy customers in Moldova and Romania. J Herb Med. 2020;21:100346.
44. Catella C, Camero M, Lucente MS, Fracchiolla G, Sblano S, Tempesta M, et al. Virucidal and antiviral effects of Thymus vulgaris essential oil on feline coronavirus. Res Vet Sci. 2021;137:44–7.
45. Gaafar AA, Ali SI, Kutkat O, Kandeil AM, El-Hallouty SM. Bioactive Ingredients and Anti-influenza (H5N1), Anticancer, and Antioxidant Properties of Urtica urens L. Jordan J Biol Sci. 2020;13.
46. Sargin SA. Potential anti-influenza effective plants used in Turkish folk medicine: A review. J Ethnopharmacol. 2021;265:113319.
47. Yazdi FF, Ghalamkari G, Toghyani M, Modaresi M, Landy N. Efficiency of Tribulus terrestris L. as an antibiotic growth promoter substitute on performance and immune responses in broiler chicks. Asian Pac J Trop Dis. 2014;4(Suppl 1):S1014–8.
48. Choi JG, Lee H, Kim YS, Hwang YH, Oh YC, Lee B, et al. Aloe vera and its components inhibit influenza A virus-induced autophagy and replication. Am J Chin Med. 2019;47(6):1307–24.
49. Pourghanbari G, Nili H, Moattari A, Mohammadi A, Iraji A. Antiviral activity of the oseltamivir and Melissa officinalis L. essential oil against avian influenza A virus (H9N2). Virusdisease. 2016;27:170–8.
50. Mieres-Castro D, Ahmar S, Shabbir R, Mora-Poblete F. Antiviral activities of eucalyptus essential oils: Their effectiveness as therapeutic targets against human viruses. Pharmaceuticals. 2021;14(12):1210.
51. Vimalanathan S, Hudson J. Anti-Influenza virus activities of commercial oregano oils and their carriers. J Appl Pharm Sci. 2012;2(7):214–8.
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