Volume 8 - Pre-proof (Accepted manuscript)
pbp 2026, 8 - Pre-proof (Accepted manuscript): 0-0 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
soleimani M, Aidy A, Ghaneialvar H, Karimi E. Effects of Wild Pistachio Fruit Herbal Mouthwash on Gingival Healing Following Clinical Crown Lengthening Surgery. pbp 2026; 8
URL: http://pbp.medilam.ac.ir/article-1-391-en.html
URL: http://pbp.medilam.ac.ir/article-1-391-en.html
1- Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , miladsoleimani28@gmail.com
2- Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran
2- Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran
Abstract: (11 Views)
Objective: Chlorhexidine (CHX) is the gold standard for preventing dental plaque but is associated with undesirable side effects. This preliminary clinical study aimed to evaluate the feasibility of a herbal mouthwash derived from Pistacia atlantica fruit at concentrations of 1%, 5%, and 10% as an alternative to CHX, assessing postoperative healing following clinical crown lengthening surgery.
Methods: Patients were randomly allocated into five groups (n = 10 per group): CHX mouthwash (0.2%), herbal mouthwash (1%, 5%, or 10%), or normal saline (NS) placebo. The Modified Gingival Index (MGI) and Plaque Index (PI) were recorded on the day of surgery. After two weeks, assessments included mouthwash taste, parotid gland swelling, tongue discoloration, tooth staining index (SI), PI, and MGI. Data were analyzed using Kruskal–Wallis and Mann–Whitney tests with Bonferroni correction for multiple comparisons (adjusted significance threshold p < 0.005). Effect sizes (r) were calculated for significant pairwise comparisons.
Results: The herbal mouthwash showed comparable efficacy to CHX in improving MGI and PI, with no statistically significant difference between the combined herbal groups and CHX (p = 0.002, r = 0.62). CHX caused significantly greater tooth staining than all herbal concentrations (p < 0.001, r = 0.74). Taste preference significantly favored the herbal mouthwash over CHX (p < 0.001, r = 0.62). None of the CHX-associated adverse effects (tooth staining, tongue discoloration, parotid swelling, unpleasant taste) were observed in patients using the herbal mouthwash to the same extent.
Conclusion: Compared to chlorhexidine, the herbal mouthwash exhibited minimal adverse effects, including reduced parotid swelling, tongue and tooth discoloration, and improved taste acceptance. Additionally, it demonstrated comparable efficacy to chlorhexidine in improving gingival and plaque indices, suggesting that it may serve as an effective and well-tolerated alternative to chlorhexidine.
Type of Study: Research |
Subject:
Bioactive Compounds
Received: 2026/01/20 | Accepted: 2026/04/26 | Published: 2026/01/1
Received: 2026/01/20 | Accepted: 2026/04/26 | Published: 2026/01/1
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |