Azza Dawoud, Sali Dawoud Hussien, Mohammed Abdalbagi, Mohamed El Hassan Shayoub,
Volume 7, Issue 1 (2-2025)
Abstract
Objective: It is acknowledged that psoriasis is the most prevalent autoimmune condition brought on by the improper activation of the immune system.
the lack of possible cure and associated severe side effects in allopathic medicines have led to extensive research in natural products with antipsoriatic activity. Bearing in mind this, and based on previous studies conducted at the Medicinal and Aromatic Plant and Traditional Medicine Research Institute (MAPTMRI), in which the activity of the Aloe sinkatan plant was proven as an effective treatment for psoriasis, it was selected to formulate, optimize and evaluate a new emulgel from Aloe sinkatana plant extract used as an anti-psoriatic agent.
Method: The study included a multi-phase process that included the collecting and extraction of plants. Based on pre-formulation studies like solubility and compatibility studies, liquid paraffin, propylene glycol, Tween-20 and Span-20, alcohol, and DEMSO were selected for the forumaltion. The emulgels were designed, formulate and optimized using a 2³ factorial design. Spreadability and viscosity were considered dependent variables, while the quantities of emulsifying agent, gelling agent and, liquid paraffin were chosen as independent formulation variables. Physical appearance and physiochemical parameters like stability, pH, viscosity, spreadability, and percentage medication content were evaluated for the produced formulations.
Results: Regression analysis showed that all three independent variables significantly affected the response variables. The formulation was optimized using a response surface plot using Design Expert software 8.0.7.1. The R² values for the response's viscosity and spreadability were 0.9915 and 0.9761, respectively.
Conclusion: Aloe sinkatana extract was used as an active component in the formulation of the emulgel form. Formula F3 shows good physicochemical characteristics and a higher percent of drug content than other formulations; therefore, it was selected as an optimal formula.
Azza Dawoud, Sali Dawoud, Mohammed Abdalbagi,
Volume 7, Issue 4 (12-2025)
Abstract
Objectives: One of the most significant Sudanese medicinal plants is Aloe sinkatana, which has a high pharmacological activity and is historically used to treat psoriasis and other skin conditions. This study aims to evaluate the Aloe sinkatana plant's anti-psoratic properties.
Methods: The Imiquimod-induced psoriasis mice model was used to evaluate to the antipsoriatic effect of the Aloe sinkatana plant; the effects of 0.1% & 0.2% extracts of Aloe sinkatana extract on five groups of mice were used, and compared with the conventional medication Dexamethasone
Results: The extracts showed a significant and remarkably strong anti-psoriatic effect since the percentage of psoriasis-like symptoms was reduced in groups treated with 0.2% Aloe extract, 0.1% Aloe extract & dexamethasone, was 86%, 84%, and 68%, respectively. Both extract concentrations also improved the psoriatic lesions and decreased the grading of the treated groups' psoriasis area and severity index (PASI) scale.
Conclusion: Due to the constant research to develop a safe and effective topical preparation for the treatment of psoriasis, the current study provided an enhanced anti-psoriatic treatment, represented by Aloe sinkatana extract and it may be beneficial in the pharmaceutical formulation of new safe and effective medication for the treatment of psoriasis.
