Mohammad Mehdi Zangeneh, Navid Etemadi, Samira Zand, Ali Pirnejad-Talatapeh, Akram Zangeneh, Ghobad Abangah, Hori Ghaneialvar, Volume 5, Issue 2 (12-2023)
Abstract
Objective: Attention to the daily prescription of large amounts of drugs by doctors; In recent years, much attention has been paid to the effect of plants in the treatment and prevention of drug poisoning. Matricaria chamomilla is one of the oldest medicinal plants known to man and its use dates back to ancient Greece.In this research, the protective effect of green tea extract in hepatotoxicity caused by acetaminophen has been investigated. Methods: So that 48 adult male mice were randomly divided into 6 groups. The control group received only physiological serum.The M. chamomile group received 250 mg/kg and (AgNP)M chamomilla received 0.5 mg/kg for 30 days. The acetaminophen group was prescribed 500 mg/kg of acetaminophen orally, and the experimental groups (acetaminophen + M. chamomile extract) were given chamomile extract with a dose of 250 mg/kg and (silver nanoparticle of M. chamomile plant + acetaminophen) (AgNP) M. chamomilla with a dose of 0.5 received mg/kg for 30 days and a toxic dose of acetaminophen was prescribed on the 29th day. Results: On the 31st day, blood was drawn to measure alanine transferase (ALT) and aspartate transferase (AST), and after that, the animals' livers were placed in 10% formalin for histopathological examination. The serum levels of ALT and AST enzymes in the silver nanoparticle group were significantly reduced compared to other groups. (P<0.05) so that in histopathological studies, liver necrosis, congestion of red blood cells and the accumulation of inflammatory cells in (AgNP) M. chamomilla were reduced compared to the acetaminophen group. Conclusion: According to the results of this research (AgNP)M chamomilla is probably involved in liver necrosis caused by acetaminophen. It has a protective role.
Navid Etemadi, Seyyed Meysam Abtahi Froushani, Akram Zangeneh, Mohammad Mehdi Zangeneh, Ali Pirnejad-Talatapeh, Ghobad Abangah , Siavosh Kaki Sahne, Shahin Ehteshamfar, Volume 7, Issue 2 (5-2025)
Abstract
Objective:One of the common diseases among the communities is stomach ulcer. Common treatments for this disease include drugs that reduce acid secretion, which, while effective, have side effects. The use of medicinal plants as an aid in the treatment of this disease is considered.One of the application fields of nanobiotechnology is the use of silver nanoparticles (Nanosilver particles) for a new solution in the treatment of digestive diseases.This study was conducted to determine the effect of silver nanoparticles combined with Artemisia dracunculusextract for the prevention of ethanol-induced gastric ulcer. Method: To conduct this study, 28 rats (220-250 grams) were used in 4 experimental groups. The experimental groups included the saline group, the groups receiving aqueous Artemisia dracunculusextract with a dose of 1000 mg/kg and silver nanoparticles of Artemisia dracunculusaqueous extract with a dose of 0.5 mg/kg, the omeprazole group with a dose of 20 mg/kg orally, and the negative control group. 12 days after the treatment, gastric ulcer was induced by feeding half a cc of pure ethanol to each animal. After 4 hours, the animals were anesthetized, blood was drawn from the heart, and the stomach tissue was separated and used for histopathological and biochemical studies. The amount of superoxide dismutase (SOD) in serum and the amount of malondialdehyde (MDA) in stomach tissue were determined. Results and Discussion: The results in the tested groups show a decrease in the ulcer index and an increase in the percentage of wound inhibition and the protective effect of silver nano particles of the Artemisia dracunculusextract. The significant increase in the amount of SOD and the significant decrease in MDA due to the administration of nanoparticles of Artemisia dracunculusextract and omeprazole indicate the beneficial effect of the silver nanoparticle of the Artemisia dracunculusextract based on its antioxidant effects (reduction of oxidative stress).
