Robert Ikechukwu Uroko, Chinomso Friday Aaron, Mercylyn Ezinne Uche, Chinedu Aguwamba, Elisha Uko Ogwo, Paul Chukwuemaka Nweje-Anyalowu, Solomon Nnah Ijioma,
Volume 4, Issue 2 (12-2022)
Abstract
Objective: This study evaluated the effect of ethanol extract of Aju Mbaise (EEAM) on sperm morphology, semen quality, sex hormonal levels, gonadosomatic index and testicular histology of Avodart-induced rats.
Material and Methods: The study had normal control, Avodart control, EEAM control, Avodart+500mg/kg EEAM, and Avodart +1000mg/kg EEAM groups. The rats were orally administered 0.5 mg/kg Avodart and 1 hour later treated with EEAM for 28 consecutive days. The Avodart control had milky white semen with low Ph, volume and semen consistency compared to the normal control and EEAM treated rats with creamy white semen with higher pH and semen consistency, respectively.
Results: The results indicated a substantial decline in spermatozoa mass motility; spermatozoa live proportion, spermatozoa concentrations, normal spermatozoa proportions, animal live weight, paired testes weight and relative testicular weight in the Avodart control compared to the normal control. The Avodart induction caused a significant reduction in the serum testosterone, follicle-stimulating hormone and luteinising hormone levels compared to the normal control. Also, there was a substantial decline in spermatogenic activity and the absence of mature spermatocytes in the lumen of the seminiferous tubules in the Avodart control relative to the normal control and EEAM control. The alterations in the sperm morphology, semen quality, sex hormonal levels and gonadosomatic index were significantly reverted to normal in the EEAM treated Avodart induced rats in a dose-dependent manner compared to the Avodart control.
Conclusion: These findings showed that EEAM ameliorates Avodart toxicity and improves fertility by restoring sperm quality and sex hormonal levels to normal in rats.
Aliasghar Manouchehri,
Volume 5, Issue 1 (6-2023)
Abstract
Objective: According to world health organization (WHO), paraquat is categorized as moderately hazardous, but its ingestion is associated with high toxicity and mortality and there is no specific antidote for paraquat poisoning.
Case report: A 75-year-old female was admitted to the emergency room with an alleged history of ingestion of 1 glass of paraquat (liquid form). Examination of oral cavity showed tongue and mucosal erosion. Cardiovascular, chest, and CNS examinations were normal. Gastric lavage was performed and she received IV fluids and an antiemetic as a supportive measure. Intravenous steroids and N-Acetylcysteine and proton pump inhibitors were added to the treatment. Input/output charting and vital monitoring was done. Her initial chest X ray, ECG, and abdominal ultrasonography were normal. Initially, her CBC, Electrolytes, liver function tests, and kidney function tests were within the normal ranges. During the hospital stay, blood creatinine increased to 2.2 mg% and kidney function tests deteriorated gradually. The patient developed AKI and was supported with haemodialysis. Patient's condition improved over period of time, she started accepting orally and urine output was adequate. She was then discharged with stable vital signs and was asked to follow-up in the outpatient department. Early diagnosis, aggressive decontamination and supportive care should be established in paraquat poisoning.
Conclusion: Since there is no known antidote for it, further absorption must be prevented in order to manage paraquat poisoning successfully.