Background: Many people in the world suffer from gastroduodenal ulcers, therefore, studying the therapeutic strategies of these ulcers are considered as the research priorities in any country. The aim of this study was to survey the preventive property of zinc nanoparticles of Matricaria chamomilla on ethanol-induced gastroduodenal ulcers in rats. Methods: In this study, 30 adult females rats were divided into 5 groups, randomly: negative healthy control receiving distilled water, untreated negative control receiving distilled water, positive control receiving omeprazole 60 mg/kg, one group receiving the aqueous extract of M. chamomilla at 200 mg/kg concentrations, and another group receiving the zinc nanoparticles of aqueous extract M. chamomilla at 0.5mg/kg concentrations. After 14 days, gastroduodenal ulcers were caused by ethanol. Four hours after oral administration of ethanol, the stomach, and duodenum samples of the rats were dissected. Malondialdehyde, Superoxide dismutase activity, and prevention index were measured and histopathological studies were performed. Results: The zinc nanoparticles of aqueous extract M. chamomilla could significantly decrease the raised levels of MDA and INU and enhance SOD and IU as compared to other groups. Also, the zinc nanoparticles of aqueous extract prevented significantly small, medium, and large gastroduodenal ulcers as compared to other groups. Conclusion: It seems that the zinc nanoparticles of aqueous extract M. chamomilla can prevent gastroduodenal ulcers in rats without any side effect.
Navid Etemadi, Seyyed Meysam Abtahi Froushani, Akram Zangeneh, Mohammad Mehdi Zangeneh, Ali Pirnejad-Talatapeh, Ghobad Abangah , Siavosh Kaki Sahne, Shahin Ehteshamfar, Volume 7, Issue 2 (5-2025)
Abstract
Objective:One of the common diseases among the communities is stomach ulcer. Common treatments for this disease include drugs that reduce acid secretion, which, while effective, have side effects. The use of medicinal plants as an aid in the treatment of this disease is considered.One of the application fields of nanobiotechnology is the use of silver nanoparticles (Nanosilver particles) for a new solution in the treatment of digestive diseases.This study was conducted to determine the effect of silver nanoparticles combined with Artemisia dracunculusextract for the prevention of ethanol-induced gastric ulcer. Method: To conduct this study, 28 rats (220-250 grams) were used in 4 experimental groups. The experimental groups included the saline group, the groups receiving aqueous Artemisia dracunculusextract with a dose of 1000 mg/kg and silver nanoparticles of Artemisia dracunculusaqueous extract with a dose of 0.5 mg/kg, the omeprazole group with a dose of 20 mg/kg orally, and the negative control group. 12 days after the treatment, gastric ulcer was induced by feeding half a cc of pure ethanol to each animal. After 4 hours, the animals were anesthetized, blood was drawn from the heart, and the stomach tissue was separated and used for histopathological and biochemical studies. The amount of superoxide dismutase (SOD) in serum and the amount of malondialdehyde (MDA) in stomach tissue were determined. Results and Discussion: The results in the tested groups show a decrease in the ulcer index and an increase in the percentage of wound inhibition and the protective effect of silver nano particles of the Artemisia dracunculusextract. The significant increase in the amount of SOD and the significant decrease in MDA due to the administration of nanoparticles of Artemisia dracunculusextract and omeprazole indicate the beneficial effect of the silver nanoparticle of the Artemisia dracunculusextract based on its antioxidant effects (reduction of oxidative stress).
Introduction: Antioxidants, whether produced naturally within the body or obtained from external sources, are crucial in safeguarding health by defending cells from the damage caused by oxidative stress. Phytochemicals, naturally occurring in medicinal plants, possess significant antioxidant properties and are gaining widespread attention for their health benefits. Numerous studies have explored the antioxidant capacities of various plant species. In this study, we investigate the antioxidant activity of methanolic extracts from Capsicum annuum, Hypericum helianthemoides, and Dianthus orientalis Adams. Materials & Methods: The aerial parts of the plants were first dried and finely ground. Methanolic extracts were prepared by combining the plant material with methanol. The total antioxidant capacity of the extracts was then determined using the Ferric Reducing Antioxidant Power (FRAP) assay. The results were measured at a wavelength of 570 nm using an ELISA reader. Results: Our findings revealed that the methanolic extracts of Hypericum helianthemoides, Capsicum annuum, and Dianthus orientalis Adams exhibited maximum total antioxidant capacities of 2.79, 2.48, and 1.96 mmol Fe²⁺/L, respectively. Conclusion: The findings from this study highlight the significant antioxidant capacities of methanolic extracts derived from Capsicum annuum, Hypericum helianthemoides, and Dianthus orientalis Adams. These plants demonstrated strong potential in reducing oxidative stress, a key factor in the prevention of various chronic diseases, including cardiovascular disorders, neurodegenerative diseases, and cancer. Given their substantial antioxidant activity, these plants could be further explored for development into natural therapeutic agents or incorporated into functional foods and nutraceuticals. Additionally, their incorporation into pharmaceutical formulations could provide a natural alternative to synthetic antioxidants, offering fewer side effects and promoting better consumer health. Future research should focus on identifying the specific bioactive compounds responsible for these antioxidant properties and investigating their mechanisms of action in clinical settings.
