Seyed Morteza Hosseini, Namdar Yousofvand, Samira Zand, Ali Piranejad-Talatapeh, Akram Zangeneh,
Volume 5, Issue 2 (12-2023)
Abstract
Objectives: One of the application areas of nanobiotechnology is the use of silver nanoparticles (Nanosilver particles) for a new solution in medical treatments. In the present study, the researchers investigate the effect of nano silver particles of the aqueous extract of Artemisia aucheri on skin wound healing among male rats.
Material and Methods: After creating wounds in 48 rats, they were randomly divided into 6 groups. Treated with 0.2% AgNPs ointment, 0.2% AgSO4 ointment, 0.2% A. aucheri ointment, 3% tetracycline ointment, Eucerin basal ointment, and untreated control group. The tested groups were treated for ten days.
Results: Treatment with AgNPs ointment significantly increased the amount of vascular contraction, hexose amine and hydroxyproline, and fibrocyte and fibrocyte to fibroblast ratio. Also, in the mentioned group, the wound area and the total number of cells, neutrophils and lymphocytes decreased significantly compared to other groups.
Conclusion: The nano silver particles of the aqueous extract of A. aucheri accelerate the healing process of skin wounds and reduce the time required for complete wound healing.
Azza Dawoud, Sali Dawoud, Mohammed Abdalbagi,
Volume 7, Issue 3 (1-2025)
Abstract
Objectives: One of the most significant Sudanese medicinal plants is Aloe sinkatana, which has a high pharmacological activity and is historically used to treat psoriasis and other skin conditions. This study aims to evaluate the Aloe sinkatana plant's anti-psoratic properties.
Methods: The Imiquimod-induced psoriasis mice model was used to evaluate to the antipsoriatic effect of the Aloe sinkatana plant; the effects of 0.1% & 0.2% extracts of Aloe sinkatana extract on five groups of mice were used, and compared with the conventional medication Dexamethasone
Results: The extracts showed a significant and remarkably strong anti-psoriatic effect since the percentage of psoriasis-like symptoms was reduced in groups treated with 0.2% Aloe extract, 0.1% Aloe extract & dexamethasone, was 86%, 84%, and 68%, respectively. Both extract concentrations also improved the psoriatic lesions and decreased the grading of the treated groups' psoriasis area and severity index (PASI) scale.
Conclusion: Due to the constant research to develop a safe and effective topical preparation for the treatment of psoriasis, the current study provided an enhanced anti-psoriatic treatment, represented by Aloe sinkatana extract and it may be beneficial in the pharmaceutical formulation of new safe and effective medication for the treatment of psoriasis.
