Naser Abbasi, Hori Ghaneialvar, Sania Saneei, Mohammad Mahdi Zangeneh, Akram Zangeneh,
Volume 3, Issue 1 (6-2021)
Abstract
Ethnomedicinal plants are considered as the recent resources for producing components to healt wounds. Stevia rebaudiana is a native plant in Iran, which has been used as an anti-inammatory, antioxidant, antibacterial, antifungal, antiparasitic, antiviral, and antidiabetic agent. In this study, the authors describe the property of aqueous extract of S. rebaudiana on wound healing markers in Sprague-Dawley male rats. Full-thickness excisional wounds (2×2 cm) was induced on the back of 32 rats. In this study, rats were randomly divided into four main groups (n=8), untreated (control) and treated with 1ml basal cream, 1ml tetracycline (3%), and 1ml S. rebaudiana aqueous extract 10% for 10 days. Animals of each group were euthanized at 10 days post-injury (DPI) and wounds were assessed through gross and histopathological analyses. Treated animals with S. rebaudiana demonstrated a considerable decrease in the wound area during the experiment compared to control, basal cream, and tetracycline groups. Parameters such as healing tissue alignment and epithelialization indicated substantial changes when compared to other groups. Moreover, treatment with S. rebaudiana decreased the number of wound surface area, lymphocytes, and macrophages, it increased the number of blood vessels and fibrocytes compared to other groups at 10 days. Thus, the present research shows the wound healing effect of the S. rebaudiana, suggesting to be used as a therapeutic supplement. Additional in vivo researches and clinical trials would be needed to justify the findings.
Ali Ranjbari, Mohamadreza Nazer,
Volume 6, Issue 1 (6-2024)
Abstract
Objective: The skin is a barrier between the human body and the external environment and protects the body against external chemical and physical factors. Despite major advances in wound treatment, wound healing remains one of the most important challenges ahead. Some medicinal plants with anti-inflammatory, antimicrobial and antioxidant properties are effective in healing and repairing wounds. The present study is a review of medicinal plants that are used in the ethnobotanical knowledge of western Iran for wound healing in skin wounds.
Methodology: In this study, the keywords of medicinal plants, wound healing, skin wound, West Azerbaijan, East Azerbaijan, Kurdistan, Kermanshah, Ilam, Khuzestan and ethnobotany were used to search for articles. The investigated databases were Google Scholar, SID, Megaran, PubMed, Scopus. Related ethnobotanical articles were used to review the texts.
Results: Based on the obtained results, it was determined that medicinal plants such as Sisymbrium sophia L, Fumaria officinalis L., Plantago major L., Alcea spp., Urtica spp., Astragalus gossypinus Fischer., Fumaria officinalis, Iperata cylindrica (L.), Polygonum aviculare L., Sanguisorba minor Scop., Alcea angulata, Aristolochia olivieri, Calendula persica, Citrullus colocynthis, Fumaria parviflora, Nerium oleander, Scrophularia striata, Allium schoenoprasum, Ixiolirion tataricum, Thymus Kotchyanous, Adonis aestivalis, Cardaria draba, Althaea officinalis, Beta vulgaris , Carthamus tinetorius L., Chrysanthemum coronarium, Helianthus annus L., Matricaria recutita L. and Vicia sativa are medicinal plants that heal wounds in these areas.
Conclusion: Medicinal plants and plant derivatives due to the presence of antioxidant compounds and secondary medicinal compounds such as tannins, anthocyanins, flavon, flavonoids, phenols and also less side effects than chemical drugs and species diversity in the treatment of skin wounds and Reports of their traditional effects in the treatment of wounds present them as an inexpensive and effective choice for wound healing. The need for more pharmacological and clinical studies to produce wound healing drugs seems necessary and necessary.
Fatemeh Saadat, Anahita Fathi Azarbayjani,
Volume 6, Issue 2 (7-2024)
Abstract
Objective: Intravenous albumin administration increases blood circulation and enhances wound healing. Topical application of albumin can inhibit the growth of certain bacteria on topical wounds. Topical caffeine can induce vascularization and the formation of blood vessels on the skin. The purpose of this work is to explore for the first time the effect of topical albumin and caffeine on wound healing rate in rat models.
Methods: This work aimed to develop albumin and caffeine-loaded nanofibers by the electrospinning method and to evaluate their topical effect on wound healing. Nanofiber formation was assessed by SEM and considered using FT-IR spectroscopy. The therapeutic activity of topical albumin and caffeine was investigated on a full-thickness excision skin model.
Results: Albumin alone or in combination with caffeine effectively reduced the exposed wound area. Wound contraction at the end of week 2 was higher in albumin and caffeine loaded nanofiber group (96%) relative to the control group (79%).
Conclusion: Data show that daily albumin-loaded wound dressing displayed good healing properties and enhanced wound closure rate. These findings may indicate the successful application of the sauce as a promising tool in wound healing therapy.
