Volume 4, Issue 1 (6-2022)                   Plant Biotechnol Persa 2022, 4(1): 56-62 | Back to browse issues page

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Ghareghani S, Sadighara P, Mahsa Khodaei S, Pirhadi M. Does Dietary Monosodium Glutamate Cause Neuro-toxicity on The Central Nervous System? A Review. Plant Biotechnol Persa. 2022; 4 (1) :56-62
URL: http://pbp.medilam.ac.ir/article-1-108-en.html
Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran. , m.pirhadi371@gmail.com
Abstract:   (314 Views)
Monosodium glutamate (MSG) is an additive which is substantially applied in commercially processed foods in order to increase the flavor and sapidity and make a unique flavor which cannot be provided by any other ingredient. Since the discovery of endogenous amino acid glutamate (as a neurotransmitter) in human body, the possible toxicity of exogenous glutamic acid has attracted the attention of numerous scholars. Accordingly, various animal studies have been documented on toxic impacts of MSG on different parts of the body including central nervous system, liver, adipose tissue, reproductive organs, and other systems. Thus, since that time, the safety of MSG has repeatedly been checked and reaffirmed within the scientific communities due to the contradict results. This literature review article specifically aimed to discuss the probable safety of dietary MSG for central nervous system and also provide an integrated information from several studies documented on possible neurotoxic effects of monosodium glutamate on glutamate receptors of Central Nervous System in order to elevate the public awareness about it. Collecting the results of all studied articles seems to supports the hypothesis of safety. In fact, it seems that MSG as a food additive within the limited amounts as well as natural levels of glutamic acid which is present in food supplies provides no serious hazard to the human CNS.

 
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Type of Study: Review/Systemtic review | Subject: Clinical
Received: 2022/04/11 | Accepted: 2022/04/14 | Published: 2022/04/18

References
1. Beyreuther K, Biesalski HK, Fernstrom JD, Grimm P, Hammes WP, Heinemann U, et al. Consensus meeting: monosodium glutamate–an update. European J Clin Nutr 2007;61(3):304-13.
2. Yeomans MR, Gould NJ, Mobini S, Prescott J. Acquired flavor acceptance and intake facilitated by monosodium glutamate in humans. Physiol Behav 2008; 93(4-5):958-66.
3. Zhang Y, Venkitasamy C, Pan Z, Liu W, Zhao L. Novel umami ingredients: Umami peptides and their taste. J Food Sci 2017; 82(1):16-23.
4. Yamaguchi S. Basic properties of umami and its effects on food flavor. Food Rev Int 1998; 14(2-3):139-76.
5. Chakraborty SP. Patho-physiological and toxicological aspects of monosodium glutamate. Toxicol Mechan Meth 2019; 29(6): 389-96.
6. Thuy LN, Salanta L, Tofana M, Socaci SA, Fărcaș AC, Pop C. A Mini Review About Monosodium Glutamate. Bulletin UASVM Food Sci Technol 2020; 77(1):1-12.
7. Husarova V, Ostatnikova D. Monosodium glutamate toxic effects and their implications for human intake: a review. Jmed Res 2013(2):1-12.
8. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr2000; 130(4): 1007S-15S.
9. Collison KS, Makhoul NJ, Zaidi MZ, Al-Rabiah R, Inglis A, Andres BL, et al. Interactive effects of neonatal exposure to monosodium glutamate and aspartame on glucose homeostasis. Nutr Methabol 2012;9(1):1-13.
10. Mukherjee S, Manahan-Vaughan D. Role of metabotropic glutamate receptors in persistent forms of hippocampal plasticity and learning. Neuropharmacol 2013; 66:65-81.
11. López-González M, Díaz-Casares A, González-García M, Peinado-Aragonés C, Barbancho M, de Albornoz MC, et al. Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area. J Physiol Biochem 2018; 74(2):325-34.
12. Ferraguti F. Metabotropic glutamate receptors as targets for novel anxiolytics. Current Opin Pharmacol 2018; 38:37-42.
13. Pereira V, Goudet C. Emerging trends in pain modulation by metabotropic glutamate receptors. FrontMolecular Neurosci 2019; 11:464.
14. Ferraguti F. Metabotropic Glutamate Receptors in Amygdala Functions. mGLU Receptors: Springer; 2017. p. 241-77.
15. Fernstrom JD. Monosodium glutamate in the diet does not raise brain glutamate concentrations or disrupt brain functions. Annals of Nutrition and Metabolism. 2018;73(5):43-52.
16. Olney JW. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science. 1969;164(3880):719-21.
17. Amat P, Peláez B, Blazquez J, Pastor F, Sánchez A. Lectinhistochemistry and ultrastructure of microglial response to monosodium glutamate-mediated neurotoxicity in the arcuate nucleus. Histol Histopathol 1999; 14(1):165-74.
18. Reynolds WA, Lemkey-Johnston N, Stegink L. Morphology of the fetal monkey hypothalamus after in utero exposure to monosodium glutamate. Glutamic Acid: Adv Biochem Physiol 1979:217-29.
19. Gonzalez-Burgos I, Perez-Vega M, Beas-Zarate C. Neonatal exposure to monosodium glutamate induces cell death and dendritic hypotrophy in rat prefrontocortical pyramidal neurons. Neurosci letters 2001; 297(2):69-72.
20. Rivera‐Cervantes M, Torres JS, Feria‐Velasco A, Armendariz‐Borunda J, Beas‐Zárate C. NMDA and AMPA receptor expression and cortical neuronal death are associated with p38 in glutamate‐induced excitotoxicity in vivo. J Neurosci 2004; 76(5):678-87.
21. Hashem HE, Safwat ME-D, Algaidi S. The effect of monosodium glutamate on the cerebellar cortex of male albino rats and the protective role of vitamin C (histological and immunohistochemical study). J Molecular Histol 2012; 43(2):179-86.
22. Umukoro S, Oluwole GO, Olamijowon HE, Omogbiya AI, Eduviere AT. Effect of monosodium glutamate on behavioral phenotypes, biomarkers of oxidative stress in brain tissues and liver enzymes in mice. World J Neurosci 2015; 5(05):339.
23. Onaolapo OJ, Onaolapo AY, Akanmu M, Gbola O. Evidence of alterations in brain structure and antioxidant status following ‘low-dose’monosodium glutamate ingestion. Pathophysiol 2016; 23(3):147-56.
24. Saikrishna K, Kumari R, Chaitanya K, Biswas S, Nayak PG, Mudgal J, et al. Combined administration of monosodium glutamate and high sucrose diet accelerates the induction of type 2 diabetes, vascular dysfunction, and memory impairment in rats. J Environmental Pathol Toxicol Oncol 2018; 37(1).
25. Vorhees CV. A test of dietary monosodium glutamate developmental neurotoxicity in rats: a reappraisal. Annals Nutr Metabol 2018; 73(5):36-42.
26. Omogbiya AI, Ben-Azu B, Eduviere AT, Eneni A-EO, Nwokoye PO, Ajayi AM, et al. Monosodium glutamate induces memory and hepatic dysfunctions in mice: ameliorative role of Jobelyn® through the augmentation of cellular antioxidant defense machineries. Toxicol Res 2020:1-13.
27. Hawkins RA. The blood-brain barrier and glutamate. Am J Clin Nutr 2009; 90(3):867S-74S.
28. Peruzzo B, Pastor FE, Blázquez JL, Schöbitz K, Peláez B, Amat P, et al. A second look at the barriers of the medial basal hypothalamus. Experimental Brain Res 2000; 132(1):10-26.
29. Fernstrom JD, Cameron JL, Fernstrom MH, McConaha C, Weltzin TE, Kaye WH. Short-term neuroendocrine effects of a large oral dose of monosodium glutamate in fasting male subjects. The J Clin Endocrinol Metabol 1996;81(1):184-91.
30. Graham T, Sgro V, Friars D, Gibala M. Glutamate ingestion: the plasma and muscle free amino acid pools of resting humans. Am J Physiol Endocrinol Metabol 2000; 278(1):E83-E9.
31. Yamaguchi S, Takahashi C. Hedonic functions of monosodium glutamate and four basic taste substances used at various concentration levels in single and complex systems. Agric Biolog Chem 1984; 48(4):1077-81.
32. Husarova V, Ostatnikova D. Monosodium glutamate toxic effects and their implications for human intake: a review. European J Clin Nutr 2007; 34:758-65.

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