Volume 4, Issue 1 (6-2022)                   Plant Biotechnol Persa 2022, 4(1): 71-77 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hosseini S F. Pharmacological and Antioxidant Activities of Rhus coriaria L. (Sumac). Plant Biotechnol Persa. 2022; 4 (1) :71-77
URL: http://pbp.medilam.ac.ir/article-1-119-en.html
1Department of Biology, Faculty of Basic Sciences, Mazandaran University, Babolsar, Iran , saberabaszade1370@gmail.com
Abstract:   (74 Views)
Rhus coriaria L. (Anacardiaceae), generally known as sumac, is a commonly used powder spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, R. coriaria (RC) has been used in traditional medicine for the management and treatment of many ailments including hemorrhoids, wound healing, diarrhea, and reduction of blood sugar, cholesterol and uric acid levels. R. coriaria is rich in various classes of phytochemicals including polyphenol compounds, flavonoids, anthocyanins, tannins, organic acids, and many others. By virtue of its bioactive, R. coriaria possesses powerful antioxidant capacities that have ameliorative and therapeutic benefits for many common diseases including neurodegenerative disease, diabetes, and cancer. The purpose of this study is a brief review of the effects of R. coriaria on diabetes, cancer, hyperlipidemia, as well as the study of anti-inflammatory and antioxidant properties of this plant. Due to its mineral elements, neurotransmitters, organic acids and high antioxidant ability, Sumac plant can cause significant changes in various organs of the body when consumed.  To sum up, the findings summarized here can be used as a useful dietary supplement and an attractive target for drug discovery.

 
Full-Text [PDF 2204 kb]   (15 Downloads)    
Type of Study: Research | Subject: Bioactive Compounds
Received: 2022/03/9 | Accepted: 2022/10/1 | Published: 2022/05/9

References
1. Zarei A, Shariati M, Shekar Forosh S, Ashtiyani SC, Rasekh. The effect of Physalis alkekengi extract on the physiologic function of organ tissues: A mini-review. Arak Med Univ J 2012; 15(7):94-104.
2. Akbari-Fakhrabadi, M., Heshmati, J., Sepidarkish, M., & Shidfar, F. Effect of RC (Rhus Coriaria) on blood lipids: a systematic review and meta-analysis. Complement Therap Med 2018; 40: 8-12.
3. Abu-Reidah IM, Ali-ShtayehMS, Jamous RM, Arra´ez-Roma´n D, Segura-Carretero A. HPLC-DAD-ESI-MS/MS screening of bioactive components from Rhus coriaria L. (RC) fruits.Food Chem 2015; 166:179–191.
4. Lee JC, Lim KT, Jang YS. Identification of Rhus verniciflua Stokes compounds that exhibit free radical Scavenging and antiapoptotic properties. Biochem Biophys Acta 2002; 1570: 181–191.
5. Lee SH, Nan JX, Zhao YZ, Woo SW, Park EJ, Kang TH, Seo GS, Kim YC, Sohn DH. The chalcone butein from Rhus verniciflua shows antifibrogenic activity. Planta Med 2003; 69:990–994
6. Park KY, Jung GO, Lee KT, Choi J, Choi MY, Kim GT, Jung HJ, Park HJ. Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua. J Ethnopharmacol 2004; 90:73–79
7. Giancarlo S, Rosa LM, Nadjafi F, Francesco M. Hypoglycaemic activity of two spices extracts: Rhus coriaria L. and Bunium persicum Boiss. Nat Prod Res 2006; 20:882–886.
8. Doğan A, Çelik İ. Healing effects of RC (Rhus coriaria) in streptozotocin-induced diabetic rats. Pharmaceutical Biol 2016; 54(10), 2092-2102.
9. Hajmohammadi Z, Heydari M, Nimrouzi M, and et al. Rhus coriaria L. increases serum Apolipoprotein-A1 and high-density lipoprotein cholesterol levels: a double-blind placebo controlled Randomized clinical trial. J Integr Med 2018; 16(1):45-50.
10. Madihi Y, Merrikhi A, Baradaran A, et al. Impact of RC on postprandial high-fat oxidative Stress. 2013; 3: 2.
11. Rouhi-Boroujeni H, Mosharraf S, Gharipour M, Asadi-Samani M, Rouhi-Boroujeni H. Anti hyperelipidemic effects of RC (Rhus coriaria L.): Can RC strengthen antihyperlipidemic Effect of statins. Der Pharm Lett 2016; 8(3): 1-5.
12. Shabana MM, El Sayed AM, Yousif MF, El Sayed AM, Sleem AA. Bioactive constituents from Harpephyllum caffrum Bernh. And Rhus coriaria L. Pharmacogn Mag 2011; 7(28): 298-306.
13. Beretta G, Rossoni G, Santagati NA, Facino RM. Anti-ischemic activity and endothelium dependent vasorelaxant effect of hydrolysable tannins from the leaves of Rhus coriaria (RC) in isolated rabbit heart and thoracic aorta. Planta Med 2009; 75(14):1482-1488.
14. M. Kosar, B. Bozan, F. Temelli, K.H.C. Baser, Antioxidant activity and phenolic composition of RC (Rhus coriaria L.) extracts. Food Chem 2007; 103: 952–959.
15. R. Kossah, C. Nsabimana, H. Zhang, W. Chen, Optimization of extraction of polyphenols from Syrian RC (Rhus coriaria L.) and Chinese RC (Rhus typhina L.) fruits. Res J Phytochem 2010; 4: 146–153.
16. Gulcin I. Antioxidant activity of L-adrenaline: an activity-structure insight. Chem Biol Interact 2009; 179: 71–80.
17. Ak T, Gulcin I. Antioxidant and radical scavenging properties of curcumin. Chem. Biol. Interact 2008; 174: 27–37.
18. Gulcin I, Elias R, Gepdiremen A, Boyer L, Köksal E. A comparative study on the antioxidant activity of fringe tree (Chionanthus virginicus L.) extracts. Afr. J. Biotechnol 2007; 6(4), 410–418.
19. Peng Y, Zhang H, Liu R, Mine Y, McCallum J, Kirby C, Tsao R. Antioxidant and anti-inflammatory activities of pyranoanthocyanins and other polyphenols from staghorn RC (Rhus hirta L.) in Caco-2 cell models. Journal of Functional Foods 2016; 20: 139-147.
20. Hortelano S. Molecular Basis of the Anti-Inflammatory Effects of Terpenoids. Inflammation &# 38; Allergy- Drug Targets (Formerly??? Current Drug Targets 2009; 8(1): 28-39.
21. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27:1047–1053.
22. Giancarlo §, S. Hypoglycaemic activity of two spices extracts: Rhus coriaria L. and Bunium persicum Boiss. Natural Prod Res 2006; 20(9): 882-886.
23. Daisy P, Eliza J, Mohamed Farook KA. A novel dihydroxy gym emic triacetate isolated from Gymnema sylvestre possessing normoglycemic and hypolipidemic activity on STZ induced diabetic rats. J Ethnopharmacol 2009; 126: 339–344.
24. Patel AN, Bandawane DD, Mhetre NK. Pomegranate (Punica granatum Linn.) leaves attenuate disturbed glucosehomeostasis and hyperglycemia mediated hyperlipidemia and oxidativestress in streptozotocin induced diabetic rats. Eur J Integr Med 2014; 6:307–321.
25. Bedekar A, Shah K, Koffas M. Natural products for type II diabetes treatment. Adv Appl Microbiol 2010; 71: 21–73.
26. Ahangarpour A, Heidari H, Junghani MS, Absari R, Khoogar M, Ghaedi E. Effects of hydroalcoholic extract of Rhus coriaria seed on glucose and insulin related biomarkers, lipid profile, and hepatic enzymes in nicotinamide streptozotocin-induced type II diabetic male mice. Res Pharm Sci 2017; 12: 416–424.
27. Lee JC, Kim J, Jang YS. Ethanol eluted extract of Rhus verniciflua Stokes showed both antioxidant and cytotoxic effects on mouse thymocytes depending on the dose and time of the treatment. J. Biochem Mol Biol 2001; 36(3): 337–343.
28. Lee JC, Lee KY, Kim J, Na CS, Jung NC, Chung GH, Jang YS. Extract from Rhus verniciflua stokes is capable of inhibiting and diarilmetan compounds: discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia. Int. J. Biol. Macromol 2018; 119: 857–863.
29. Jann MW, Shirley KL, Small GW. Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors. Clin Pharm 2002; 41, 719–739.
30. Ali TB, Schleret TR, Reilly BM, Chen WY, Abagyan R. Adverse effects of cholinesterase inhibitors in dementia, according to the pharmacovigilance databases of the United-States and Canada. PLoS ONE 2015; 10, e0144337.
31. Singhal AK, Naithani V, Bangar. Medicinal plants with a potential to treat Alzheimer and associated symptoms. Int J Nutr Pharmacol Neurol Dis 2012; 2(2): 84.
32. Ardalani H, Moghadam MH, Rahimi R, Soltani J, Mozayanimonfared A, Moradi M, Azizi A. RC as a novel adjunctive treatment in hypertension: a randomized, double-blind, placebo-controlled clinical trial. Rsc Advances 2016; 6(14): 11507-11512.
33. Zieske AW, Malcom GT, Strong JP. Natural history and risk factors of atherosclerosis in children and youth: the PDAY study. Pediatr Pathol Mol Med 2002; 21(2):213-237.
34. Mohammadi S, Montasser Kouhsari S, Monavar Feshani A. Antidiabetic properties of the ethanolic extract of Rhus coriaria fruits in rats. Daru 2010; 18(4):270-275.
35. Sabzghabaee AM, Kelishadi R, Golshiri K, Ghannadi A, Badri S. Clinical Effects of Rhus coriaria Fruits on Dyslipidemia308 in Adolescents: a Triple-blinded Randomized Placebocontrolled Trial. Med Arch 2014; 68(5):308-312.
36. 36. Asgary S, Salehizadeh L, Keshvari M, et al. Potential Cardioprotective Effects of RC Capsule in Patients With Hyperlipidemia: A Triple-Blind Randomized, Placebo-Controlled Crossover Trial. J Am Coll Nutr 2018; 37(4):286-292.
37. Shafiei M, Nobakht M, Moazzam AA. Lipid-lowering effect of Rhus coriaria L. (RC) fruit extract in hypercholesterolemic rats. Pharmazie 2011; 66(12):988-992.
38. Shidfar F, Rahideh ST, Rajab A, et al. The Effect of RC (Rhus coriaria L.)Powder on Serum Glycemic Status, ApoB, ApoA-I and Total Antioxidant Capacity in Type 2 Diabetic Patients. Iran J Pharm Res 2014; 13(4):1249-1255.
39. Sierra-Johnson J, Fisher RM, Romero-Corral A, et al. Concentration of apolipoprotein B is comparable with the apolipoprotein B/apolipoprotein A-I ratio and better than routine clinical lipid measurements in predicting coronary heart disease mortality: findings from a multi-ethnic US population. Eur Heart J Mar 2009; 30(6):710-717.
40. Candan F. Effect of Rhus coriaria L. (Anacardiaceae) on superoxide radical scavenging and xanthine oxidase activity. J Enzyme Inhib Med Chem 2003; 18(1): 59-62.
41. Kim S, Park SE, Sapkota K, Kim MK, Kim SJ. Leaf extract of Rhus verniciflua Stokes protects dopaminergic neuronal cells in a rotenone model of Parkinson's disease. Journal of Pharmacy and Pharmacol 2011; 63(10): 1358-1367.
42. Beretta G, Rossoni G, Santagati NA, Facino RM. Anti-ischemic activity and endothelium-dependent vasorelaxant effect of hydrolysable tannins from the leaves of Rhus coriaria (RC) in isolated rabbit heart and thoracic aorta. Planta Medica 2009; 75(14): 1482-1488.
43. Radhakrishnan R, Zakaria MNM, Islam MW, Chen HB, Kamil M, Chan K, Al-Attas A. Neuropharmacological actions of Portulaca oleraceae L v. sativa (Hawk). J Ethnopharmacol 2001; 76(2): 171-176.
44. Khalilpour S, Sangiovanni E, Piazza S, Fumagalli M, Beretta G, Dell’Agli M. In vitro evidences of the traditional use of Rhus coriaria L. fruits against skin inflammatory conditions. J Ethnopharmacol 2019; 238: 111829
45. Gulcin I.Antioxidant activity of L-adrenaline: an activity-structure insight. Chem Biol Interact 2009; 179, 71–80.
46. Lee JC, Kim J, Jang YS. Ethanol eluted extract of Rhus verniciflua Stokes showed both antioxidant and cytotoxic effects on Mouse thymocytes depending on the dose and time of the treatment. J. Biochem. Mol. Biol 2001; 36(3): 337–343.
47. Alsamri H, Athamneh K, Pintus G, Eid AH, Iratni R. Pharmacological and antioxidant activities of Rhus coriaria L.(Sumac). Antioxidants 2021; 10(1): 73.

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.