Volume 7, Issue 3 (1-2025)
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Saghabashi A, Sadeghi A, Ghodratie M, hatami H, Alavi Rostami S F, Yazdehi M, et al . Antimicrobial Potential of Satureja Species: A Review of Bioactive Compounds and Molecular Mechanisms. pbp 2025; 7 (3)
URL: http://pbp.medilam.ac.ir/article-1-262-en.html
URL: http://pbp.medilam.ac.ir/article-1-262-en.html
Ahdiyeh Saghabashi1 
, Atena Sadeghi2 , Mohammad Ghodratie3 , Hosna Hatami4 , Seyedeh Faride Alavi Rostami5 , Mahdi Yazdehi , Ebrahim Mahmoudi6 , Saina Najafi7 , Zahra Mottaghiyan *8
, Atena Sadeghi2 , Mohammad Ghodratie3 , Hosna Hatami4 , Seyedeh Faride Alavi Rostami5 , Mahdi Yazdehi , Ebrahim Mahmoudi6 , Saina Najafi7 , Zahra Mottaghiyan *8
1- Department of Microbiology, Faculty of Sciences, Agriculture and Modern Technology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2- Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran
3- Department of Medical Microbiology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
4- Department of medical biotechnology, Kermanshah university of medical science, Kermanshah,Iran
5- Department of Microbiology, Faculty of Biological Sciences, Islamic Azad University Tehran-North Branch, Tehran, Iran.
6- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
7- Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
8- , Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran ,university.ac55@gmail.com
2- Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran
3- Department of Medical Microbiology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
4- Department of medical biotechnology, Kermanshah university of medical science, Kermanshah,Iran
5- Department of Microbiology, Faculty of Biological Sciences, Islamic Azad University Tehran-North Branch, Tehran, Iran.
6- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
7- Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
8- , Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran ,
Abstract: (461 Views)
Objective: The genus Satureja (Lamiaceae), commonly referred to as savory, has been traditionally valued for its medicinal properties, particularly its antimicrobial activity.
Methodology: Methodology: In this review study, the key words satureja, antimicrobial resistance, antibiotics, carvacrol, thymol, multidrug-resistant were used to search for articles. Databases such as Google Scholar, SID, Magiran, PubMed, Scopus were used for searching.
Results: Various species of Satureja are rich in bioactive compounds such as thymol, carvacrol, and terpenoids, which exhibit strong antibacterial, antifungal, and antiviral properties. These essential oils primarily act by disrupting bacterial cell membranes, inhibiting biofilm formation, and interfering with bacterial metabolism and DNA replication. This review critically examines the antimicrobial properties of nine Satureja species, focusing on their bioactive compounds, molecular mechanisms, and potential applications.
Conclusion: Given the growing challenge of antimicrobial resistance (AMR), the therapeutic potential of Satureja is discussed in the context of alternative antimicrobial strategies and industrial applications.
Methodology: Methodology: In this review study, the key words satureja, antimicrobial resistance, antibiotics, carvacrol, thymol, multidrug-resistant were used to search for articles. Databases such as Google Scholar, SID, Magiran, PubMed, Scopus were used for searching.
Results: Various species of Satureja are rich in bioactive compounds such as thymol, carvacrol, and terpenoids, which exhibit strong antibacterial, antifungal, and antiviral properties. These essential oils primarily act by disrupting bacterial cell membranes, inhibiting biofilm formation, and interfering with bacterial metabolism and DNA replication. This review critically examines the antimicrobial properties of nine Satureja species, focusing on their bioactive compounds, molecular mechanisms, and potential applications.
Conclusion: Given the growing challenge of antimicrobial resistance (AMR), the therapeutic potential of Satureja is discussed in the context of alternative antimicrobial strategies and industrial applications.
Type of Study: Review/Systemtic review |
Subject:
Herbal Drugs
Received: 2024/11/10 | Accepted: 2025/01/26 | Published: 2025/01/29
Received: 2024/11/10 | Accepted: 2025/01/26 | Published: 2025/01/29
References
1. Antimicrobial resistance: a silent pandemic. Nat Commun. 2024;15(1):6198. https://doi.org/10.1038/s41467-024-50457-z
2. da Silva Dantas A. Antimicrobial resistance. Mol Microbiol. 2022;117(5):959-60. doi:
4. Şahin F, Karaman I, Güllüce M, Öğütçü H, Şengül M, Adıgüzel A, et al. Evaluation of antimicrobial activities of Satureja hortensis L. Journal of ethnopharmacology. 2003;87(1):61-5. https://doi.org/10.1016/S0378-8741(03)00110-7
5. Asfaram A, Sadeghi H, Goudarzi A, Panahi Kokhdan E, Salehpour Z. Ultrasound combined with manganese-oxide nanoparticles loaded on activated carbon for extraction and pre-concentration of thymol and carvacrol in methanolic extracts of Thymus daenensis, Salvia officinalis, Stachys pilifera, Satureja khuzistanica, and mentha, and water samples. Analyst. 2019;144(6):1923-34. doi:10.1039/C8AN02338G.
6. Vilmosh N, Delev D, Kostadinov I, Zlatanova H, Kotetarova M, Kandilarov I, et al. Anxiolytic Effect of Satureja montana Dry Extract and its Active Compounds Rosmarinic Acid and Carvacrol in Acute Stress Experimental Model. J Integr Neurosci. 2022;21(5):124. doi:10.31083/j.jin2105124.
7. Tariverdizadeh N, Mohebodini M, Ebadi A, Heydari HR. Response of Satureja hortensis L. to gamma radiation and its impact on secondary metabolite content and biochemical characteristics. Int J Radiat Biol. 2023;99(9):1424-32. doi:10.1080/09553002.2023.2173821.
8. Khlebnikova DA, Efanova EM, Danilova NA, Shcherbakova YV, Rivera Sidorova I. Flavonoid Accumulation in an Aseptic Culture of Summer Savory (Satureja hortensis L.). Plants (Basel). 2022;11(4). https://doi.org/10.3390/plants11040533.
9. Singh J, Luqman S, Meena A. Carvacrol as a Prospective Regulator of Cancer Targets/Signalling Pathways. Curr Mol Pharmacol. 2023;16(5):542-58. doi:10.2174/1874467215666220705142954.
10. Bhardwaj K, Dubey W. SWEET MARJORAM (ORIGANUM MAJORANA L.) AS A MAGICAL BIO- PROTECTIVE AGENT AGAINST FOOD SPOILAGE: A REVIEW. Carpathian Journal of Food Science and Technology. 2020;12:5-15. https://doi.org/10.34302/crpjfst/2020.12.1.1.
11. Khaledi A, Meskini M. A Systematic Review of the Effects of Satureja Khuzestanica Jamzad and Zataria Multiflora Boiss against Pseudomonas Aeruginosa. Iran J Med Sci. 2020;45(2):83-90. doi:10.30476/IJMS.2019.72570.
12. Abbasloo E, Amiresmaili S, Shirazpour S, Khaksari M, Kobeissy F, Thomas TC. Satureja khuzistanica Jamzad essential oil and pure carvacrol attenuate TBI-induced inflammation and apoptosis via NF-κB and caspase-3 regulation in the male rat brain. Sci Rep. 2023;13(1):4780. https://doi.org/10.1038/s41598-023-31891-3.
13. Gomes F, Dias MI, Lima Â, Barros L, Rodrigues ME, Ferreira I, et al. Satureja montana L. and Origanum majorana L. Decoctions: Antimicrobial Activity, Mode of Action and Phenolic Characterization. Antibiotics (Basel). 2020;9(6). doi:10.3390/antibiotics9060294.
14. Bimbiraitė-Survilienė K, Stankevičius M, Šuštauskaitė S, Gęgotek A, Maruška A, Skrzydlewska E, et al. Evaluation of Chemical Composition, Radical Scavenging and Antitumor Activities of Satureja hortensis L. Herb Extracts. Antioxidants (Basel). 2021;10(1). https://doi.org/10.3390/antiox10010053.
15. Giweli A, Džamić AM, Soković M, Ristić MS, Marin PD. Antimicrobial and antioxidant activities of essential oils of Satureja thymbra growing wild in Libya. Molecules. 2012;17(5):4836-50. doi:10.3390/molecules17054836.
16. Said-Al Ahl HAH, Kačániova M, Mahmoud AA, Hikal WM, Čmiková N, Szczepanek M, et al. Phytochemical Characterization and Biological Activities of Essential Oil from Satureja montana L., a Medicinal Plant Grown under the Influence of Fertilization and Planting Dates. Biology (Basel). 2024;13(5). doi:10.3390/biology13050328.
17. Eftekhar F, Raei F, Yousefzadi M, Ebrahimi SN, Hadian J. Antibacterial activity and essential oil composition of Satureja spicigera from Iran. Z Naturforsch C J Biosci. 2009;64(1-2):20-4. doi:10.1515/znc-2009-1-204.
18. Choulitoudi E, Bravou K, Bimpilas A, Tsironi T, Tsimogiannis D, Taoukis P, et al. Antimicrobial and antioxidant activity of Satureja thymbra in gilthead seabream fillets edible coating. Food and Bioproducts Processing. 2016;100:570-7. doi: 10.1016/j.fbp.2016.06.013.
19. Oke F, Aslim B, Ozturk S, Altundag S. Essential oil composition, antimicrobial and antioxidant activities of Satureja cuneifolia Ten. Food Chemistry. 2009;112(4):874-9. https://doi.org/10.1016/j.foodchem.2008.06.061.
20. Skočibušić M, Bezić N, Dunkić V. Phytochemical composition and antimicrobial activities of the essential oils from Satureja subspicata Vis. growing in Croatia. Food Chemistry. 2006;96(1):20-8. https://doi.org/10.1016/j.foodchem.2005.01.051.
21. Dodoš T, Rajčević N, Janaćković P, Novaković J, Marin PD. Intra- and interpopulation variability of Balkan endemic - Satureja kitaibelii based on n-alkane profile. Biochemical Systematics and Ecology. 2019;85:68-71. https://doi.org/10.1016/j.bse.2019.05.008.
22. Nezhadasad Aghbash B, Dehghan G, Movafeghi A, Talebpour AH, Pouresmaeil M, Maggi F, et al. Chemical compositions and biological activity of essential oils from four populations of Satureja macrantha C.A.Mey. Journal of Essential Oil Research. 2021;33(2):133-42. https://doi.org/10.1080/10412905.2020.1871085.
23. Sharifi-Rad J, Sharifi-Rad M, Hoseini-Alfatemi SM, Iriti M, Sharifi-Rad M, Sharifi-Rad M. Composition, Cytotoxic and Antimicrobial Activities of Satureja intermedia C.A.Mey Essential Oil. Int J Mol Sci. 2015;16(8):17812-25. https://doi.org/10.1080/10412905.2020.1871085.
24. Dodoš T, Janković S, Marin PD, Rajčević N. Essential Oil Composition and Micromorphological Traits of Satureja montana L., S. subspicata Bartel ex Vis., and S. kitaibelii Wierzb. Ex Heuff. Plant Organs. Plants (Basel). 2021;10(3). https://doi.org/10.3390/plants10030511.
25. Hajibonabi A, Yekani M, Sharifi S, Nahad JS, Dizaj SM, Memar MY. Antimicrobial activity of nanoformulations of carvacrol and thymol: New trend and applications. OpenNano. 2023;13:100170. https://doi.org/10.1016/j.onano.2023.100170.
26. Nostro A, Roccaro AS, Bisignano G, Marino A, Cannatelli MA, Pizzimenti FC, et al. Effects of oregano, carvacrol and thymol on Staphylococcus aureus and Staphylococcus epidermidis biofilms. J Med Microbiol. 2007;56(Pt 4):519-23. https://doi.org/10.1016/j.onano.2023.100170.
27. Mączka W, Twardawska M, Grabarczyk M, Wińska K. Carvacrol-A Natural Phenolic Compound with Antimicrobial Properties. Antibiotics (Basel). 2023;12(5). https://doi.org/10.3390/antibiotics12050824.
28. Chroho M, Rouphael Y, Petropoulos SA, Bouissane L. Carvacrol and Thymol Content Affects the Antioxidant and Antibacterial Activity of Origanum compactum and Thymus zygis Essential Oils. Antibiotics. 2024;13(2):139. https://doi.org/10.3390/antibiotics13020139.
29. Peter S, Sotondoshe N, Aderibigbe BA. Carvacrol and Thymol Hybrids: Potential Anticancer and Antibacterial Therapeutics. Molecules. 2024;29(10). https://doi.org/10.3390/molecules29102277.
30. Jiang Y, Geng M, Bai L. Targeting Biofilms Therapy: Current Research Strategies and Development Hurdles. Microorganisms. 2020;8(8). doi:10.3390/microorganisms8081222.
31. Tuon FF, Suss PH, Telles JP, Dantas LR, Borges NH, Ribeiro VST. Antimicrobial Treatment of Staphylococcus aureus Biofilms. Antibiotics (Basel). 2023;12(1). doi:10.3390/antibiotics12010087.
32. Sharma S, Mohler J, Mahajan SD, Schwartz SA, Bruggemann L, Aalinkeel R. Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative Treatment. Microorganisms. 2023;11(6). doi:10.3390/microorganisms11061614.
33. Mohammad Haji S, Bahar Nayeri F, Seyed Mostafa P. Antimicrobial and antibiofilm effects of Satureja hortensis essential oil against Escherichia coli and Salmonella isolated from poultry. Iranian Journal of Microbiology. 2021;13(1). https://doi.org/10.18502/ijm.v13i1.5495.
34. Seyedtaghiya MH, Fasaei BN, Peighambari SM. Antimicrobial and antibiofilm effects of Satureja hortensis essential oil against Escherichia coli and Salmonella isolated from poultry. Iran J Microbiol. 2021;13(1):74-80. https://doi.org/10.18502/ijm.v13i1.5495.
35. Filomena N, Florinda F, Antonio dA, Raffaele C, Fernando Jesus A-Z, Adriano Gomez da C, et al. Essential Oils and Microbial Communication. In: Hany AE-S, editor. Essential Oils. Rijeka: IntechOpen; 2019. p. Ch. 10. doi: 10.5772/intechopen.85638.
36. Rutherford ST, Bassler BL. Bacterial quorum sensing: its role in virulence and possibilities for its control. Cold Spring Harb Perspect Med. 2012;2(11). doi:10.1101/cshperspect.a012427.
37. Qaralleh H, Saghir SAM, Al-limoun MO, Dmor SM, Khleifat K, Al-Ahmad BEM, et al. Effect of Matricaria aurea Essential Oils on Biofilm Development, Virulence Factors and Quorum Sensing-Dependent Genes of Pseudomonas aeruginosa. Pharmaceuticals. 2024;17(3):386. doi:10.3390/ph17030386.
38. Nazzaro F, Fratianni F, De Martino L, Coppola R, De Feo V. Effect of essential oils on pathogenic bacteria. Pharmaceuticals (Basel). 2013;6(12):1451-74. https://doi.org/10.3390/ph6121451.
39. Swamy MK, Akhtar MS, Sinniah UR. Antimicrobial Properties of Plant Essential Oils against Human Pathogens and Their Mode of Action: An Updated Review. Evid Based Complement Alternat Med. 2016;2016:3012462. https://doi.org/10.1155/2016/3012462.
40. Aghbash BN, Pouresmaeil M, Dehghan G, Nojadeh MS, Mobaiyen H, Maggi F. Chemical Composition, Antibacterial and Radical Scavenging Activity of Essential Oils from Satureja macrantha C.A.Mey. at Different Growth Stages. Foods. 2020;9(4):494. https://doi.org/10.3390/foods9040494.
41. He Q, Chen J, Xie Z, Chen Z. Wild-Type Isocitrate Dehydrogenase-Dependent Oxidative Decarboxylation and Reductive Carboxylation in Cancer and Their Clinical Significance. Cancers (Basel). 2022;14(23). doi:10.3390/cancers14235779.
42. Arnold PK, Finley LWS. Regulation and function of the mammalian tricarboxylic acid cycle. J Biol Chem. 2023;299(2):102838. doi:10.1016/j.jbc.2022.102838.
43. Tretter L, Adam-Vizi V. Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress. Philos Trans R Soc Lond B Biol Sci. 2005;360(1464):2335-45. doi:10.1098/rstb.2005.1764.
44. Rezvanpanah S, Rezaei K, Golmakani MT, Razavi SH. Antibacterial properties and chemical characterization of the essential oils from summer savory extracted by microwave-assisted hydrodistillation. Braz J Microbiol. 2011;42(4):1453-62. doi:10.1590/S1517-838220110004000031.
45. Khaledi A, Meskini M. A Systematic Review of the Effects of Satureja Khuzestanica Jamzad and Zataria Multiflora Boiss against Pseudomonas Aeruginosa. Iranian Journal of Medical Sciences. 2020;45(2):83-90. doi:10.30476/IJMS.2019.72570.
46. Maurya A, Prasad J, Das S, Dwivedy AK. Essential oils and their application in food safety. Frontiers in Sustainable Food Systems. 2021;5:653420. https://doi.org/10.3389/fsufs.2021.653420.
47. Pino-Otín MR, Gan C, Terrado E, Sanz MA, Ballestero D, Langa E. Antibiotic properties of Satureja montana L. hydrolate in bacteria and fungus of clinical interest and its impact in non-target environmental microorganisms. Scientific Reports. 2022;12(1):18460. https://doi.org/10.1038/s41598-022-22419-2.
48. Kirkan B, Sarikurkcu C, Amarowicz R. Composition, and antioxidant and enzyme‐inhibition activities, of essential oils from Satureja thymbra and Thymbra spicata var. spicata. Flavour and fragrance journal. 2019;34(6):436-42. https://doi.org/10.1002/ffj.3522.
49. Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. J Nutr Sci. 2016;5:e47. doi:10.1017/jns.2016.41.
50. Alcaraz M, Olivares A, Achel DG, García-Gamuz JA, Castillo J, Alcaraz-Saura M. Genoprotective Effect of Some Flavonoids against Genotoxic Damage Induced by X-rays In Vivo: Relationship between Structure and Activity. Antioxidants (Basel). 2021;11(1). doi:10.3390/antiox11010094.
51. Malczak I, Gajda A. Interactions of naturally occurring compounds with antimicrobials. Journal of Pharmaceutical Analysis. 2023;13(12):1452-70. https://doi.org/10.1016/j.jpha.2023.09.014.
52. Shamsudin NF, Ahmed QU, Mahmood S, Ali Shah SA, Khatib A, Mukhtar S, et al. Antibacterial Effects of Flavonoids and Their Structure-Activity Relationship Study: A Comparative Interpretation. Molecules. 2022;27(4):1149. doi:10.2174/0929867321666140916113443.
53. Meunier A, Cornet F, Campos M. Bacterial cell proliferation: from molecules to cells. FEMS Microbiol Rev. 2021;45(1). doi:10.1093/femsre/fuaa046.
54. Donadio G, Mensitieri F, Santoro V, Parisi V, Bellone ML, De Tommasi N, et al. Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids. Pharmaceutics. 2021;13(5):660. doi:10.3390/pharmaceutics13050660.
55. Wang JD, Levin PA. Metabolism, cell growth and the bacterial cell cycle. Nat Rev Microbiol. 2009;7(11):822-7. doi:10.1038/nrmicro2202.
56. Shamsudin NF, Ahmed QU, Mahmood S, Ali Shah SA, Khatib A, Mukhtar S, et al. Antibacterial Effects of Flavonoids and Their Structure-Activity Relationship Study: A Comparative Interpretation. Molecules. 2022;27(4). doi:10.3390/molecules27041149.
57. Donadio G, Mensitieri F, Santoro V, Parisi V, Bellone M, Tommasi N, et al. Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids. Pharmaceutics. 2021;13:660. doi:10.3390/pharmaceutics13050660.
58. Sureshjani MH, Yazdi FT, Mortazavi A, Shahidi F, Behbahani BA. Antimicrobial effect of Satureja bachtiarica extracts aqueous and ethanolic on Escherichia coli and Staphylococcus aureus. 2013.
59. Hagh LG, Arefian A, Farajzade A, Dibazar S, Samiea N. The antibacterial activity of “Satureja hortensis” extract and essential oil against oral bacteria. Dental Research Journal. 2019;16(3):153-9.
60. Deans S, Svoboda KP. Antibacterial activity of summer savory (Satureja hortensis L) essential oil and its constituents. Journal of Horticultural Science. 1989;64(2):205-10. https://doi.org/10.1080/14620316.1989.11515946.
61. Santos JD, Coelho E, Silva R, Passos CP, Teixeira P, Henriques I, et al. Chemical composition and antimicrobial activity of Satureja montana byproducts essential oils. Industrial Crops and Products. 2019;137:541-8. https://doi.org/10.1016/j.indcrop.2019.05.058.
62. Khalil N, El-Jalel L, Yousif M, Gonaid M. Altitude impact on the chemical profile and biological activities of Satureja thymbra L. essential oil. BMC complementary medicine and therapies. 2020;20:1-11. https://doi.org/10.1186/s12906-020-02982-9.
63. Gursoy UK, Gursoy M, Gursoy OV, Cakmakci L, Könönen E, Uitto V-J. Anti-biofilm properties of Satureja hortensis L. essential oil against periodontal pathogens. Anaerobe. 2009;15(4):164-7. https://doi.org/10.1016/j.anaerobe.2009.02.004.
64. Rybczyńska-Tkaczyk K, Grenda A, Jakubczyk A, Kiersnowska K, Bik-Małodzińska M. Natural Compounds with Antimicrobial Properties in Cosmetics. Pathogens. 2023;12(2):320. https://doi.org/10.3390/pathogens12020320.
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