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DAWOUD A. Acute Dermal Toxicity Study of Aloe sinkatana. pbp 2025; 7 (3)
URL: http://pbp.medilam.ac.ir/article-1-266-en.html
URL: http://pbp.medilam.ac.ir/article-1-266-en.html
assistant professor , azzadawoudhussien@gmail.com
Abstract: (125 Views)
Objective: Aloe sinkatana is a Sudanese medicinal plant that grows naturally in Eastern Sudan in the Red Sea Mountains, mainly in the Sinkat area, where it is popularly used extensively by residents of the region to treat skin diseases. The present study was designed to investigate the toxicity of ethanolic extracts of Aloe sinkatana for topical application via acute dermal toxicity analyses.
Methods: Acute dermal toxicity was studied Based on the Economic Co-operation and Development Guidelines for the Testing of Chemicals by Appling 2000 mg/kg body weight of plant extract on the shaved area of dorsal skin of rats, only once on the first day of the study. The study period was set at 14 days, and all rats were observed every day for behavioral (salivation, tremors, convulsions, diarrhea, and lethargy) and respiratory alterations, as well as for mortality and changes in their fur, eyes, and mucous membranes.
Results: Results showed, there were no poisonous symptoms or mortality throughout the trial period; there were also no changes in the eyes, mucous membranes, skin and fur, behavior patterns, salivation, lethargy, sleep, diarrhea, coma, or tremors. No significant alterations in behavior, skin impacts, respiration, inability to consume food or water, abnormal postural changes, or hair loss were observed in any of the rats.
Conclusion: This research presents the first report on the safety of topical application of Aloe sinkatana plant extract, supporting its application in traditional Sudanese medicine in treatment of multiple skin diseases especially for psoriasis. therefore, it has the potential to be developed into a suitable safe and effective pharmaceutical formula used to treat psoriasis.
Methods: Acute dermal toxicity was studied Based on the Economic Co-operation and Development Guidelines for the Testing of Chemicals by Appling 2000 mg/kg body weight of plant extract on the shaved area of dorsal skin of rats, only once on the first day of the study. The study period was set at 14 days, and all rats were observed every day for behavioral (salivation, tremors, convulsions, diarrhea, and lethargy) and respiratory alterations, as well as for mortality and changes in their fur, eyes, and mucous membranes.
Results: Results showed, there were no poisonous symptoms or mortality throughout the trial period; there were also no changes in the eyes, mucous membranes, skin and fur, behavior patterns, salivation, lethargy, sleep, diarrhea, coma, or tremors. No significant alterations in behavior, skin impacts, respiration, inability to consume food or water, abnormal postural changes, or hair loss were observed in any of the rats.
Conclusion: This research presents the first report on the safety of topical application of Aloe sinkatana plant extract, supporting its application in traditional Sudanese medicine in treatment of multiple skin diseases especially for psoriasis. therefore, it has the potential to be developed into a suitable safe and effective pharmaceutical formula used to treat psoriasis.
Type of Study: Research |
Subject:
Pharmacognosy
Received: 2024/11/24 | Accepted: 2024/12/21 | Published: 2025/01/29
Received: 2024/11/24 | Accepted: 2024/12/21 | Published: 2025/01/29
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