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Dawoud A, Dawoud S, Abdalbagi M. Evaluation of Anti-Psoriatic Activity of Aloe sinkatana Extract on Imiquimod Induced Psoriatic-Like Dermatitis in Mice. pbp 2026; 8 (1)
URL: http://pbp.medilam.ac.ir/article-1-268-en.html
URL: http://pbp.medilam.ac.ir/article-1-268-en.html
1- Assistant professor , azzadawoudhussien@gmail.com
2- assistant professor
3- Mr..
2- assistant professor
3- Mr..
Abstract: (783 Views)
Objectives: One of the most significant Sudanese medicinal plants is Aloe sinkatana, which has a high pharmacological activity and is historically used to treat psoriasis and other skin conditions. This study aims to evaluate the Aloe sinkatana plant's anti-psoratic properties.
Methods: The Imiquimod-induced psoriasis mice model was used to evaluate to the antipsoriatic effect of the Aloe sinkatana plant; the effects of 0.1% & 0.2% extracts of Aloe sinkatana extract on five groups of mice were used, and compared with the conventional medication Dexamethasone
Results: The extracts showed a significant and remarkably strong anti-psoriatic effect since the percentage of psoriasis-like symptoms was reduced in groups treated with 0.2% Aloe extract, 0.1% Aloe extract & dexamethasone, was 86%, 84%, and 68%, respectively. Both extract concentrations also improved the psoriatic lesions and decreased the grading of the treated groups' psoriasis area and severity index (PASI) scale.
Conclusion: Due to the constant research to develop a safe and effective topical preparation for the treatment of psoriasis, the current study provided an enhanced anti-psoriatic treatment, represented by Aloe sinkatana extract and it may be beneficial in the pharmaceutical formulation of new safe and effective medication for the treatment of psoriasis.
Methods: The Imiquimod-induced psoriasis mice model was used to evaluate to the antipsoriatic effect of the Aloe sinkatana plant; the effects of 0.1% & 0.2% extracts of Aloe sinkatana extract on five groups of mice were used, and compared with the conventional medication Dexamethasone
Results: The extracts showed a significant and remarkably strong anti-psoriatic effect since the percentage of psoriasis-like symptoms was reduced in groups treated with 0.2% Aloe extract, 0.1% Aloe extract & dexamethasone, was 86%, 84%, and 68%, respectively. Both extract concentrations also improved the psoriatic lesions and decreased the grading of the treated groups' psoriasis area and severity index (PASI) scale.
Conclusion: Due to the constant research to develop a safe and effective topical preparation for the treatment of psoriasis, the current study provided an enhanced anti-psoriatic treatment, represented by Aloe sinkatana extract and it may be beneficial in the pharmaceutical formulation of new safe and effective medication for the treatment of psoriasis.
Keywords: Aloe sinkatana, Dermatitis, Extracts, Imiquimod, psoriasis area and severity index (PASI), Mice
Type of Study: Research |
Subject:
Herbal Drugs
Received: 2024/11/25 | Accepted: 2025/01/29 | Published: 2025/01/29
Received: 2024/11/25 | Accepted: 2025/01/29 | Published: 2025/01/29
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