Volume 2, Issue 1 (6-2020)                   Plant Biotechnol Persa 2020, 2(1): 22-25 | Back to browse issues page

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Gholami-Ahangaran M, Ahmadi-Dastgerdi A, Karimi-Dehkordi M. Thymol and carvacrol; as antibiotic alternative in green healthy poultry production. Plant Biotechnol Persa. 2020; 2 (1) :22-25
URL: http://pbp.medilam.ac.ir/article-1-48-en.html
Department of Clinical Sciences, Veterinary Medicine Faculty, Shahrekord Branch, Islamic Azad University, Shahrekord, IRAN , mgholami6@gmail.com
Abstract:   (1451 Views)
Thymol and carvacrol as a natural essential oils and phenol compounds, are a component derived from some medicinal plants, such as thyme and oregano species. These compounds have been shown to possess a wide range of biological activities, including antimicrobial, antioxidant, anti-infalmmatory, modulating of immunity respond and anticarcinogenic properties. One of main effects of these compounds that make them as valuable material in poultry medicine is antibacterial effect. The increasing consumption of organic and healthy meat and eggs in human society has made it increasingly necessary to use compounds that are completely natural and do not cause problems for human health. Since antibiotics are chemical compounds that can remain in meat and eggs and cause antibiotic resistance, allergies, mutations and even poisoning in humans. Therefore, utilization of compounds that are natural antibiotics can be easily fed with a higher safety in healthy poultry production. In this regard, the role of thymol and carvacrol as natural antibiotics in the poultry production has been discussed in a recent review.
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Type of Study: Review/Systemtic review | Subject: Herbal Drugs
Received: 2020/05/1 | Accepted: 2020/06/16 | Published: 2020/06/19

1. Dadgarnia M, Gholami-Ahangaran M, Shakerian A. The determination of enrofloxacin residue in quail meat, in Yazd by HPLC. Iran Food Hyg. 2018; 8: 83-90.
2. Teimuri S, Gholami-Ahangaran M, Shakerian A. The comparison of enrofloxacin residue in chicken and turkey meat, by high performance liquid chromatography in Isfahan province. Iran Food Hyg. 2018; 8: 95-100.
3. Gholami-Ahangaran M, Ghasemi Pirbalouti A, Farasat M, Fasihi K. Antimicrobial effect of Zataria multiflora, Thymus daenensis, Althea officinalis, and Urtica dioica on growth of Escherichia coli isolated from poultry colibacillosis. Iran J Vet Mic. 2015; 1: 1-10.
4. Alagawany M, El-Hack MEA, Farag MR, Tiwari R, Dhama K. Biological effects and modes of action of carvacrol in animal and poultry production and health - a review. Adv Anim Vet Sci. 2015; 3(2): 73-84.
5. Dehghani-Ashkezari A, Gholami-Ahangaran M, Fathi-Hafshejani E. The use of garlic extract in reducing the side effects of Eimeria tenella on the growth indices and mucosal tissue of the cecum in broilers. Iran Anim Biol. 2019; 11(2): 45-53.
6. Du E, Gan L, Li Z, Wang W, Liu D, Guo Y. In vitro antibacterial activity of thymol and carvacrol and their effects on broiler chickens challenged with Clostridium perfringens. J Anim sci Biotechnol 2015; 6: 58.
7. Juneja VK, Friedman M. Carvacrol, cinnamaldehyde, oregano oil, and thymol inhibit Clostridium perfringens spore germination and outgrowth in ground Turkey during chilling. J Food Prot. 2007; 70: 218-222.
8. Xu J, Zhou F, Ji BP, Pei RS, Xu N. Carvacrol and thymol had desired antimicrobial effect on E. coli. The antibacterial effects were attributed to their ability to permeabilize and depolarize the cytoplasmic membrane. Lett Appl Microbiol. 2008; 47: 174-179.
9. Moon SH, Waite-Cusic J, Huang E. Control of Salmonella in chicken meat using a combination of a commercial bacteriophage and plant-based essential oils. Food Control. 2019; https://doi.org/10.1016/j.foodcont.2019.106984
10. El-Hack ME, Alagawany M, Farag MR, Tiwari R, Karthik K, Dhama K, Zorriehzahra J, Adel M. Beneficial impacts of thymol essential oil on health and production of animals, fish and poultry: a review, J Essent Oil Res. 2016; DOI: 10.1080/10412905.2016.1153002
11. Bahmani M, Saki K, Rafieian-Kopaei M. Medicinal Plants of Thyme land in Iran. Saarbrücken: Lambert Academic Publishing; 2015.
12. Guerra-Boone L, Alvarez-Roman R, Salazar-Aranda R, Torres-Cirio A, Rivas-Galindo VM, de Torres VM, Gonzalez G, Perez-Lopez LA. Antimicrobial and antioxidant activities and chemical characterization of essential oils of Thymus vulgaris, Rosmarinus officinalis, and Origanum majorana from northeastern Mexico. Pak J Pharm Sci. 2015; 28: 363–369.
13. Khazdair MR, Ghorani V, Alavinezhad A, Boskabady MH. Pharmacological effects of Zataria multiflora Boiss L. and its constituents focus on their anti‐inflammatory, antioxidant, and immunomodulatory effects. Fundam Clin Pharmacol. 2018; 32(1): 26–50.
14. Fitsiou E, Anestopoulos I, Chlichlia K, Galanis A, Kourkoutas I, Panayiotidis MI, Pappa A. Antioxidant and antiproliferative properties of the essential oils of Satureja thymbra and Satureja parnassica and their major constituents. Anticancer Res. 2016; 36(11): 5757–5763.
15. Sánchez C, Aznar R, Sánchez G. The effect of carvacrol on enteric viruses. Int J Food Microbiol. 2015; 192: 72–76.
16. Özkan A, Erdogan A. A comparative evaluation of antioxidant and anticancer activity of essential oil from Origanum onites (Lamiaceae) and its two major phenolic components. Turkish J Biol. 2011; 35(6): 735–742.
17. Sharifi‐Rad M, Varoni EM, Iriti M, Martorell M, Setzer WN, del Mar Contreras M, Salehi B, Soltani‐Nejad A, Rajabi S, Tajbakhsh M, Sharifi‐Rad J. Carvacrol and human health: A comprehensive review. Phytother Res. 2018; 32(9): 1675-1687.
18. Hippenstiel F, Abdel-Wareth AAA, Kehraus S, Sudekum KH. Effects of selected herbs and essential oils, and their active components on feed intake and performance of broilers e a review. Arch Geflügelk. 2011;75: 226-234.
19. Bassole IH, Juliani HR. Essential oils in combination and their antimicrobial properties. Molecules. 2012; 17: 3989-4006.
20. Marchese A, Orhan IE, Daglia M, Barbieri R, Lorenzo AD, Nabavi SF, Gortzi O, Izadi M, Nabavi SM. Antibacterial and antifungal activities of thymol: a brief review of the literature. Food Chem. 2016; doi: http://dx.doi.org/10.1016/j.foodchem.2016.04.111
21. Dahiya JP, Wilkie DC, Van Kessel AG, Drew MD. Potential strategies for controlling necrotic enteritis in broiler chickens in post-antibiotic era. Anim Feed Sci Technol. 2006; 129: 60-88.
22. Penalver P, Huerta B, Borge C, Astorga R, Romero R, Perea A. Antimicrobial activity of five essential oils against origin strains of the Enterobacteriaceae family. APMIS. 2005; 113: 1-6.
23. Jerzsele A, Szeker K, Csizinszky R, Gere E, Jakab C, Mallo JJ, Galfi P. Efficacy of protected sodium butyrate, a protected blend of essential oils, their combination, and Bacillus amyloliquefaciens spore suspension against artificially induced necrotic enteritis in broilers. Poultry Sci. 2012; 91: 837-843.
24. Lacroix M, Chiasson F. The influence of MAP condition and active compounds on the radiosensitization of Escherichia coli and Salmonella typhi present in chicken breast. Radiat Phys Chem. 2004; 71: 69-72.
25. Burt S. Essential oils: their antibacterial properties and potential applications in foods e a review. Int J Food Microbiol. 2004; 94: 223-253.
26. Lambert RJW, Skandamis PN, Coote PJ, Nychas GJE. A study of the mimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol. J Appl Microbiol. 2001; 91: 453-462.
27. Memar MY, Raei P, Alizadeh N, Aghdam M A, Kafil HS. Carvacrol and thymol: strong antimicrobial agents against resistant isolates. Rev Med Microbiol. 2017; 28(2): 63-68.
28. Cowan MM. Plant products as antimicrobial agents. Clin Microbiol Rev. 1999; 12: 564-582.
29. Helander M, Alakomi H, Latva-Kala K, Mattila-Sandholm T, Pol I, Smid EJ, Gorris LGM, Wright AV. Characterization of the action of selected essential oil components on Gram-negative bacteria. J Agric Food Chem. 1998; 46: 3590-3595.
30. Brenes A, Roura E. Essential oils in poultry nutrition: main effects and modes of action. Anim Feed Sci Technol. 2010; 158: 1-14.
31. Florou-Paneri P, Palatos G, Govaris A, Botsoglou D, Giannenas I, Ambrosiadis I. Oregano herb versus oregano essential oil as feed supplements to increase the oxidative stability of Turkey meat. Int J Poult Sci. 2005; 4: 866-871.
32. Zhu X, Zhang H, Lo R. Phenolic compounds from the leaf extract of artichoke (leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities. J Agricul Food Chem. 2004; 52: 7272-7278.

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