Volume 3, Issue 2 (12-2021)
pbp 2021, 3(2): 39-47 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Kustiawan P M. A Reviw of Effectiveness of Red betel Leaves (Piper crocatum) as Antihyperglysemic Activities. pbp 2021; 3 (2) :39-47
URL: http://pbp.medilam.ac.ir/article-1-75-en.html
URL: http://pbp.medilam.ac.ir/article-1-75-en.html
Universitas Muhammadiyah Kalimantan Timur , pmk195@umkt.ac.id
Abstract: (1710 Views)
In Indonesia, diabetes is third among the leading causes of death. Elevated blood sugar (hyperglycemia) is one of the clinical features of the disease. Indonesia has abundant potential herbal plants. The red betel leaf is one of the promising herbal plants (Piper crocatum). Alkaloids, saponins, tannins, and flavonoids are among the phytochemical components found in red betel leaf. This study was used as a medium of renewable information that was supported from several previous reference sources strengthening evidence of the benefits obtained from red betel leaf as an antihyperglycemic agent. The study uses a literature review method using journal database platforms such as Google Scholar, Pubmed, and ScienceDirect as search engines for journals related to this article. The potential activity of red betel leaf as an antihyperglycemic drug which can lower blood glucose was discovered from the findings of the numerous journal sources and related studies. Red betel leaf contains flavonoid compounds that are antioxidants. Antioxidants can bind to hydroxyl radicals that harm the pancreatic cells of the islets of Langerhans, allowing these substances to activate insulin activity and treat diseases like gout, cancer, hypertension, and diabetes. Red betel leaf has an effective candidate compound has the potential to be used as an antihyperglycemic agent to lower blood glucose.
Type of Study: Review/Systemtic review |
Subject:
Pharmacognosy
Received: 2021/07/21 | Accepted: 2022/03/13 | Published: 2022/03/13
Received: 2021/07/21 | Accepted: 2022/03/13 | Published: 2022/03/13
References
1. Z. A. Amani and R. Mustarichie, “Article Review: Antihyperglycemic Activity of Several Plants in Indonesia,” Farmaka, vol. 116, no. 1, pp. 127–132, 2018.
2. S. Arokiyaraj, R. Balamurugan, and P. Augustian, “Antihyperglycemic effect of Hypericum perforatum ethyl acetate extract on streptozotocin-induced diabetic rats,” Asian Pac. J. Trop. Biomed., vol. 1, no. 5, pp. 386–390, 2011, doi: 10.1016/S2221-1691(11)60085-3.
3. R. Afsari, Kusmiyati, and I. W. Merta, “The Effect of Giving Red Betel Leaf Extract (Piper Crocatum) Against Reducing Blood Sugar Levels in Mice (Mus musculus),” J. Biol. Trop., vol. 16, no. 1, pp. 49–55, 2016.
4. F. Juliantina, D. A. Citra, B. Nirwani, T. Nurmasitoh, and E. T. Bowo, “Benefits Of Red Betel (Piper Crocatum) As Anti-Bacterial Agent Against Gram Positive And Gram Negative Bacteria,” J. Kedokt. dan Kesehat. Indones., vol. 1, no. 1, 2009.
5. F. Manoi, “Sirih merah sebagai tanaman obat multifungsi,” 2007.
6. D. Listiana, Effendi, and B. Indriati, “The Effectiveness of Red Betel Leaf Boiled Water on Reducing Blood Sugar Levels in Diabetes Mellitus Patients in the Work Area of the 2018 Saling Health Center,” J. Keperawatan Muhammadiyah Bengkulu, vol. 07, no. August 2018, pp. 62–70, 2019.
7. Y. F. Dewi, M. S. Anthara, and A. A. G. O. Dharmanyudha, “The Effectiveness of Red Betel Leaf Extract (Piper Crocatum) Against Weight Gaining in Male White Rats (Rattus Novergicus) Diabetic Conditions Induced by Alloxan,” Bul. Vet. Udayana, vol. 6, no. 1, pp. 73–79, 2014.
8. “Stock Images.” https://www.istockphoto.com/ (accessed May 19, 2021).
9. M. Fadlilah, “Benefit of Red Betel ( Piper Crocatum Ruiz & Pav .) As Antibiotics,” J. Major., vol. 4, no. 3, p. 5, 2015.
10. A. Ma’rifah, “Effect of Red Betel Leaf Extract (Piper crocatum) On the grownth of the Bacteria of Staphylococcus aureus,” Universitas Islam Negeri Syarif Hidayatullah, 2012.
11. N. Gani, L. I. Momuat, and M. M. Pitoi, “Plasma Lipid Profile of Hypercholesterolemic Wistar Mice on Giving Red Gedi (Abelmoschus manihot L.),” J. MIPA UNSRAT, vol. 2, no. 1, pp. 44–49, 2013, doi: 10.35799/jm.2.1.2013.765.
12. Sudewo, Get Rid of Diseases with Red Betel. Jakarta: Argomedia Pustaka, 2005.
13. N. Parfati and T. Windono, “Red betel (Piper crocatum Ruiz & Pav) literature review,” Media Pharm. Indones., vol. 1, no. 2, pp. 106–115, 2016.
14. K. Hati, M. Setiawan, and D. Yuliarta, “The Effect of Red Betel Leaf (Piper Crocatum) Decoction On Reducing Blood Sugar Level in White Rats (Alloxan-induced Rattus norvegicus),” Saintika Med., vol. 9, no. 1, p. 59, 2017, doi: 10.22219/sm.v9i1.4127.
15. A. K. Putri, “Study of Morphology of Piper betle L. and Its Use in Daily Life,” 2019, doi: 10.31219/osf.io/94yvq.
16. A. Rukmini, D. H. Utomo, and A. N. Laily, “Family Piperaceae Phytochemical Screening,” J. Biol. dan Pembelajarannya, vol. 7, no. 1, pp. 28–32, 2020, doi: 10.29407/jbp.v7i1.14805.
17. M. Safithri and F. Fahma, “Potency of Piper crocatum Decoction as an Antihiperglycemia in Rat Strain Sprague dawley,” HAYATI J. Biosci., vol. 15, no. 1, pp. 45–48, 2008.
18. A. Fitriyani, L. Winarti, S. Muslichah, and Nuri, “Anti-Inflammatory Test of Red Betel Leaf (Piper crocatum Ruiz & Pav) Methanol Extract on White Rats,” Majalah Obat Tradisional, vol. 16, no. 1, pp. 34–42, 2011.
19. J. Reveny, “Antimicrobial Power of Red Betel Leaf Extract and Fraction (Piper betle Linn.),” J. ILMU DASAR, vol. 12, pp. 6–12, 2011.
20. R. Sengupta and J. K. Banik, “A Review On Betel Leaf (PAN),” Int. J. Pharm. Sci. Res., vol. 4, no. 12, pp. 4519–4524, 2013.
21. “PubChem,” 2021. https://pubchem.ncbi.nlm.nih.gov/#draw=true (accessed Mar. 28, 2021).
22. Z. R. Chaudhry, A. Naseer, S. R. Chaudhry, E. R. Chaudhry, and F. R. Chaudhry, “Comparison of Extracts of Syzygium Aromaticum on the Weight of STZ induced Diabetic Rats,” J. Islam. Int. Med. Coll., vol. 11, no. 1, pp. 24–28, 2016.
23. I. Iswandha, Rosalina, and Liyanovitasari, “The Effectiveness Of Building Clove (Syzygium Aromaticum) On Blood Glucose In Diabetes Mellitus Patients In The Work Area Of Kaliwungu Puskesmas, Semarang Regency,” Universitas Ngudi Waluyo, 2019.
24. Harleen Kaur Sandhar Bimlesh, Bimlesh Kumar, Sunil Prasher, Prashant Tiwari, Manoj Salhan, and Pardeep Sharma, “A Review of Phytochemistry and Pharmacology of Flavonoids,” Int. Pharm. Sci., vol. 1, no. 1, pp. 25–41, 2011, [Online]. Available: http://www.ipharmsciencia.com/Dacuments/1/4.pdf.
25. V. Anggi and Magfirah, “The effect hypoglycemic of ethanol extract combination red betel leaf (Piper crocatum) and Dayak onion (Eleutherine palmifolia Merr) in streptozotocin-induced,” Pharmacogn. J., vol. 11, no. 6, pp. 1401–1405, 2019, doi: 10.5530/PJ.2019.11.216.
26. F. F. Abdullah, “Relationship between Diabetes and Flavonoid Structure as a Potential Source of Compounds,” Universitas Garut, 2020. https://fmipa.uniga.ac.id/read/2020/06/hubungan-penyakit-diabetes-dan-struktur-flavonoid-sebagai-sumber-senyawa-yang-potensial.html (accessed May 29, 2021).
27. D. Y. Shinta and S. Sudyanto, “Administration Of Red Belt Leaves (Piper Crocatum Ruiz & Pav) Water On Glucose And Blood Cholesterol Levels Of Male White Miice,” Sainstek J. Sains dan Teknol., vol. 8, no. 2, p. 180, 2017, doi: 10.31958/js.v8i2.480.
28. V. Irman and Etriyanti, “The Influence Of Red Belt Leaves (Piper crocatum) Booking On Blood Sugar Levels In Type II Diabetes Melitus Patients,” J. Kesehat. Saintika Meditory J. Kesehat. Saintika Meditory, vol. 1, no. 2, pp. 79–88, 2018.
29. M. R. Saputra, E. Yuniarti, and R. Sumarmin, “The Effect of Red Betel Leaf (Piper crocatum Ruiz & Pav.) Extract On Blood Glucose Induced Male Mouse (Mus musculus L.),” EKSAKTA Berk. Ilm. Bid. MIPA, vol. 19, no. 1, pp. 43–55, 2018.
30. L. Shane-McWhorter, “Biological Complementary Therapies: A Focus on Botanical Products in Diabetes,” Diabetes Spectr., vol. 14, no. 4, pp. 199–208, 2001, doi: 10.2337/diaspect.14.4.199.
31. L. Xiu et al., “Pancreatic islet regeneration by ephedrine in mice with streptozotocin-induced diabetes,” Am. J. Chin. Med., vol. 29, no. 3–4, pp. 493–500, 2001.
32. T. Ogata et al., “Promotion of β-cell differentiation by conophylline in fetal and neonatal rat pancreas,” Diabetes, vol. 53, no. 10, pp. 2596–2602, 2004, doi: 10.2337/diabetes.53.10.2596.
33. D. . Agrawal, “Diabetes and Traditional Medicine : New Reseach,” 2000, [Online]. Available: http:/ www.infinity foundation. com/ mandala/t_es/t_es_ agraw_ diabetes.html.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |