Volume 1, Issue 1 (11-2019)
pbp 2019, 1(1): 25-35 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Moradniani M, Abbaszadeh S. The Relationship between Helicobacter pylori Infection in the Stomach and Reflux Esophagitis in Patients Referring to Khorramabad Shohada Hospital, Lorestan Province, Southwest Iran between 2014 and 2018. pbp 2019; 1 (1) :25-35
URL: http://pbp.medilam.ac.ir/article-1-9-en.html
URL: http://pbp.medilam.ac.ir/article-1-9-en.html
1- Department ofInternalMedicine, Lorestan University of Medical Sciences, Khorramabad, Ir
2- Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran ,saberabaszade1370@gmail.com
2- Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran ,
Abstract: (2685 Views)
Gastroesophageal reflux disease is a common disorder of the digestive tract. Esophageal mucosa exposure to gastric acid can lead to mucosal damage such as esophagitis. The aim of this study was to determine the relationship between Helicobacter pylori infection in the stomach and reflux esophagitis in patients referring to the endoscopy units of hospitals in Khorramabad between 2014 and 2018. In this cross-sectional study, all patients who referred for endoscopy to the Endoscopy Units of Shohadaye Ashayer and Shahid Rahimi Hospitals of Khorramabad during 2014-2018 were studied. H. pylori infection was diagnosed based on pathological specimens. All patients' information including age, sex, presence of esophagitis (its grade), and H. pylori infection were recorded in the questionnaires and their relationship with esophagitis and its grade as well as H. pylori infection was statistically analyzed. Tables and charts were used to describe the data. T-test and Chi-square were used to investigate the relationship between variables. The frequency of esophagitis in our patients was 52.8%, with the highest frequency obtained for grade B esophagitis (48%). In this study, the prevalence of H. pylori infection was 57.5%. This rate was 55.4% in patients with esophagitis, with a statistically significant difference to the group without esophagitis (P=0.0009). There was a significant relationship between grade A esophagitis and H. pylori infection (P=0.0002). This study suggests a significant relationship between H. pylori infection and esophagitis in affected patients.
Type of Study: Research |
Subject:
Biotechnology
Received: 2019/09/29 | Accepted: 2019/11/10 | Published: 2019/11/20
Received: 2019/09/29 | Accepted: 2019/11/10 | Published: 2019/11/20
References
1. Alavinejad P, Hajiani E, Masjedizadeh R, Hashemi SJ, Faramarzi M, Sebghatollahi V, et al. Epidemiologic and Demographic Survey of Celiac Disease in Khuzestan Province. Middle East journal of digestive diseases. 2014;6(2):98.
2. Ciclitira PJ. AGA technical review on celiac sprue. Gastroenterology. 2001;120(6):1526-40. [DOI:10.1053/gast.2001.24056]
3. Nejad MR, Rostami K, Emami MH, Zali MR, Malekzadeh R. Epidemiology of celiac disease in Iran: a review. Middle East Journal of Digestive Diseases. 2011;3(1):5.
4. Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, et al. The Oslo definitions for coeliac disease and related terms. Gut. 2013;62(1):43-52. [DOI:10.1136/gutjnl-2011-301346]
5. Pontone S, Mastrogiorgio G, Petrarca L, Brighi M, Tonda M, Nenna R. Celiac disease and Helicobacter Pylori infection: an Ups and Downs Correlation. International Journal of Gastroenterology Disorders & Therapy. 2014;2014. [DOI:10.15344/2393-8498/2014/105]
6. Shamir R, Lerner A, Shinar E, Lahat N, Sobel E, Bar-or R, et al. The use of a single serological marker underestimates the prevalence of celiac disease in Israel: a study of blood donors. The American journal of gastroenterology. 2002;97(10):2589-94. [DOI:10.1111/j.1572-0241.2002.06028.x]
7. Feighery C. Fortnightly review: coeliac disease. BMJ: British Medical Journal. 1999;319(7204):236. [DOI:10.1136/bmj.319.7204.236]
8. Catassi C, Rätsch I, Fabiani E, Rossini M, Coppa G, Giorgi P, et al. Coeliac disease in the year 2000: exploring the iceberg. The Lancet. 1994;343(8891):200-3. [DOI:10.1016/S0140-6736(94)90989-X]
9. Green PR, Marsh M. Diagnosis of celiac disease. Best Pract Res Clin Gastroenterol 2005;19:389-400. [DOI:10.1016/j.bpg.2005.02.006]
10. Shahbazkhani B, Malekzadeh R, Sotoudeh M, Moghadam KF, Farhadi M, Ansari R, et al. High prevalence of coeliac disease in apparently healthy Iranian blood donors. European journal of gastroenterology & hepatology. 2003;15(5):475&hyhen. [DOI:10.1097/00042737-200305000-00003]
11. Rostami-Nejad M, Ehsani-Ardakani MJ, Assadzadeh H, Shahbazkhani B, Ierardi E, Losurdo G, et al. Pathological and Clinical Correlation between Celiac Disease and Helicobacter Pylori Infection; a Review of Controversial Reports. Middle East journal of digestive diseases. 2016;8(2):85. [DOI:10.15171/mejdd.2016.12]
12. Rostami K, Malekzadeh R, Shahbazkhani B, Akbari M, Catassi C. Coeliac disease in Middle Eastern countries: a challenge for the evolutionary history of this complex disorder? Digestive and liver disease. 2004;36(10):694-7. [DOI:10.1016/j.dld.2004.05.010]
13. Green PH. The many faces of celiac disease: clinical presentation of celiac disease in the adult population. Gastroenterology. 2005;128(4):S74-S8. [DOI:10.1053/j.gastro.2005.02.016]
14. Sharma M, Singh P, Agnihotri A, Das P, Mishra A, Verma AK, et al. Celiac disease: a disease with varied manifestations in adults and adolescents. Journal of digestive diseases. 2013;14(10):518-25. [DOI:10.1111/1751-2980.12078]
15. Pham BN, Musset L, Chyderiotis G, Olsson NO, Fabien N. Celiac disease diagnosis: Impact of guidelines on medical prescription in France. Journal of digestive diseases. 2014;15(8):435-43. [DOI:10.1111/1751-2980.12158]
16. LASA J, ZUBIAURRE I, DIMA G, PERALTA D, SOIFER L. Helicobacter pylori prevalence in patients with celiac disease: results from a cross-sectional study. Arquivos de gastroenterologia. 2015;52(2):139-42. [DOI:10.1590/S0004-28032015000200012]
17. Pallav K, Leffler D, Tariq S, Kabbani T, Hansen J, Peer A, et al. Noncoeliac enteropathy: the differential diagnosis of villous atrophy in contemporary clinical practice. Alimentary pharmacology & therapeutics. 2012;35(3):380-90. [DOI:10.1111/j.1365-2036.2011.04938.x]
18. Aziz I, Key T, Goodwin JG, Sanders DS. Predictors for celiac disease in adult cases of duodenal intraepithelial lymphocytosis. Journal of clinical gastroenterology. 2015;49(6):477-82.
19. Ciacci C, Squillante A, Rendina D, Limauro S, Bencivenga C, Labanca F, et al. Helicobacter pylori infection and peptic disease in coeliac disease. European journal of gastroenterology & hepatology. 2000;12(12):1283-7. [DOI:10.1097/00042737-200012120-00004]
20. Rostami-Nejad M, Aldulaimi D, Livett H, Rostami K. H. pylori associated with iron deficiency anemia even in celiac disease patients; strongly evidence based but weakly reflected in practice. Gastroenterology and Hepatology from bed to bench. 2015;8(3):178.
21. 21Rostami-Nejad M, Villanacci V, Mashayakhi R, Molaei M, Bassotti G, Zojaji H, et al. Celiac disease and Hp infection association in Iran. Revista Espanola de Enfermedades Digestivas. 2009;101(12):850. [DOI:10.4321/S1130-01082009001200004]
22. Simondi D, Ribaldone DG, Bonagura GA, Foi S, Sapone N, Garavagno M, et al. Helicobacter pylori in celiac disease and in duodenal intraepithelial lymphocytosis: Active protagonist or innocent bystander? Clinics and research in hepatology and gastroenterology. 2015;39(6):740-5. [DOI:10.1016/j.clinre.2015.03.005]
23. Konturek P, Karczewska E, Dieterich W, Hahn E, Schuppan D. Increased prevalence of Helicobacter pylori infection in patients with celiac disease. The American journal of gastroenterology. 2000;95(12):3682. [DOI:10.1111/j.1572-0241.2000.03421.x]
24. Aydogdu S, Cakir M, Yuksekkaya HA, Tumgor G, Baran M, Arikan C, et al. Helicobacter pylori infection in children with celiac disease. Scandinavian journal of gastroenterology. 2009. [DOI:10.1080/00365520802101846]
25. Villanacci V, Bassotti G, Liserre B, Lanzini A, Lanzarotto F, Genta RM. Helicobacter pylori infection in patients with celiac disease. The American journal of gastroenterology. 2006;101(8):1880-5. [DOI:10.1111/j.1572-0241.2006.00621.x]
26. Nenna R, Magliocca FM, Tiberti C, Mastrogiorgio G, Petrarca L, Mennini M, et al. Endoscopic and histological gastric lesions in children with celiac disease: mucosal involvement is not only confined to the duodenum. Journal of pediatric gastroenterology and nutrition. 2012;55(6):728-32. [DOI:10.1097/MPG.0b013e318266aa9e]
27. Jozefczuk J, Bancerz B, Walkowiak M, Glapa A, Nowak J, Piescikowska J, et al. Prevalence of Helicobacter pylori infection in pediatric celiac disease. Age [years]. 2015;6:3.0.
28. Lebwohl B, Blaser MJ, Ludvigsson JF, Green PH, Rundle A, Sonnenberg A, et al. Decreased risk of celiac disease in patients with Helicobacter pylori colonization. American journal of epidemiology. 2013:kwt234. [DOI:10.1093/aje/kwt234]
29. Medina M, Medina M, Martín G, Dikstein B, Picón S, Gorodner J, et al. [Presence of Helicobacter pylori in gastric biopsies and feces of pediatric patients with celiac disease]. Revista de gastroenterologia de Mexico. 2008;74(2):94-8.
30. Luzza F, Mancuso M, Imeneo M, Mesuraca L, Contaldo A, Giancotti L, et al. Helicobacter pylori infection in children with celiac disease: prevalence and clinicopathologic features. Journal of pediatric gastroenterology and nutrition. 1999;28(2):143-6. [DOI:10.1097/00005176-199902000-00009]
31. Diamanti A, Maino C, Niveloni S, Pedreira S, Vazquez H, Smecuol E, et al. Characterization of gastric mucosal lesions in patients with celiac disease: a prospective controlled study. The American journal of gastroenterology. 1999;94(5):1313-9. [DOI:10.1111/j.1572-0241.1999.01082.x]
32. Memeo L, Jhang J, Hibshoosh H, Green PH, Rotterdam H, Bhagat G. Duodenal intraepithelial lymphocytosis with normal villous architecture: common occurrence in H. pylori gastritis. Modern pathology. 2005;18(8):1134-44. [DOI:10.1038/modpathol.3800404]
33. Nejad MR, Rostami K, Yamaoka Y, Mashayekhi R, Molaei M, Dabiri H, et al. Clinical and histological presentation of Helicobacter pylori and gluten related gastroenteropathy. Archives of Iranian medicine. 2011;14(2):115.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |