Volume 8, Issue 2 (4-2026)
pbp 2026, 8(2): 211-221 |
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Zahed A, Teymouri Azargholenji Z, Abbasian M A. Probiotic Therapy in Burn Wound Healing: A Concise Review of Preclinical and Clinical Evidence. pbp 2026; 8 (2) :211-221
URL: http://pbp.medilam.ac.ir/article-1-403-en.html
URL: http://pbp.medilam.ac.ir/article-1-403-en.html
1- Department of Surgery, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
2- 5th-Year Medicine Student, Semmelweis University, Budapest, Hungary
3- 5th-Year Medicine Student, Semmelweis University, Budapest, Hungary ,mohammadali.abbasian@stud.semmelweis.hu
2- 5th-Year Medicine Student, Semmelweis University, Budapest, Hungary
3- 5th-Year Medicine Student, Semmelweis University, Budapest, Hungary ,
Abstract: (22 Views)
Objective: Burns are among the most common forms of skin injury and are frequently associated with high rates of complications, infections, and delayed wound healing. Key factors that impede recovery include disruption of the skin barrier, microbial imbalance (dysbiosis), persistent inflammation, and elevated oxidative stress. In recent years, probiotic therapy has emerged as a novel and complementary strategy to enhance wound repair, primarily through modulation of immune responses and the microbiota of both the skin and gut.
Methods: This concise review systematically examined peer-reviewed literature indexed in reputable databases, including PubMed, Scopus, and Web of Science. Preclinical studies, encompassing cellular and animal models, as well as clinical trials investigating the effects of probiotics on burn wound healing, were analyzed. The review focused on publications from 2010 to 2025, with emphasis on probiotic strains, routes of administration, and wound healing outcomes.
Results: Probiotics, particularly Lactobacillus plantarum, have demonstrated notable efficacy in burn wound repair by inhibiting pathogenic microorganisms, reducing inflammation, and accelerating epithelialization, even under infected or diabetic conditions. Other Lactobacillus strains, including L. acidophilus, L. rhamnosus, and L. casei, facilitate faster wound recovery by enhancing fibroblast activity and shortening the inflammatory phase. In contrast, Bifidobacterium species primarily support burn patients by strengthening mucosal immunity and mitigating systemic infections. Overall, both topical and oral probiotic interventions appear to be safe and effective adjunctive strategies, exerting their effects through modulation of the microbiome and control of inflammation.
Conclusion: Current preclinical and clinical evidence suggests that probiotic therapy can serve as a safe and effective approach to accelerate burn wound healing via modulation of the microbiome and inflammatory responses. Nonetheless, well-designed randomized clinical trials are required to determine the optimal strains, dosages, and routes of administration for maximum therapeutic benefit.
Methods: This concise review systematically examined peer-reviewed literature indexed in reputable databases, including PubMed, Scopus, and Web of Science. Preclinical studies, encompassing cellular and animal models, as well as clinical trials investigating the effects of probiotics on burn wound healing, were analyzed. The review focused on publications from 2010 to 2025, with emphasis on probiotic strains, routes of administration, and wound healing outcomes.
Results: Probiotics, particularly Lactobacillus plantarum, have demonstrated notable efficacy in burn wound repair by inhibiting pathogenic microorganisms, reducing inflammation, and accelerating epithelialization, even under infected or diabetic conditions. Other Lactobacillus strains, including L. acidophilus, L. rhamnosus, and L. casei, facilitate faster wound recovery by enhancing fibroblast activity and shortening the inflammatory phase. In contrast, Bifidobacterium species primarily support burn patients by strengthening mucosal immunity and mitigating systemic infections. Overall, both topical and oral probiotic interventions appear to be safe and effective adjunctive strategies, exerting their effects through modulation of the microbiome and control of inflammation.
Conclusion: Current preclinical and clinical evidence suggests that probiotic therapy can serve as a safe and effective approach to accelerate burn wound healing via modulation of the microbiome and inflammatory responses. Nonetheless, well-designed randomized clinical trials are required to determine the optimal strains, dosages, and routes of administration for maximum therapeutic benefit.
Type of Study: Review/Systemtic review |
Subject:
Herbal Drugs
Received: 2025/07/16 | Accepted: 2026/04/16 | Published: 2026/01/1
Received: 2025/07/16 | Accepted: 2026/04/16 | Published: 2026/01/1
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